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| 1 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Progress of mesenchymal stem cell therapy for neural and retinal diseases显示文摘Complex circuitry and limited regenerative power make central nervous system(CNS)disorders the most challenging and difficult for functional repair.With elusive disease mechanisms,traditional surgical and medical interventions merely slow down the progression of the neurodegenerative diseases.However,the number of neurons still diminishes in many patients.Recently,stem cell therapy has been proposed as a viable option.Mesenchymal stem cells(MSCs),a widely-studied human adult stem cell population,have been discovered for more than 20 years.MSCs have been found all over the body and can be conveniently obtained from different accessible tissues:bone marrow,blood,and adipose and dental tissue.MSCs have high proliferative and differentiation abilities,providing an inexhaustible source of neurons and glia for cell replacement therapy.Moreover,MSCs also show neuroprotective effects without any genetic modification or reprogramming.In addition,the extraordinary immunomodulatory properties of MSCs enable autologous and heterologous transplantation.These qualities heighten the clinical applicability of MSCs when dealing with the pathologies of CNS disorders.Here,we summarize the latest progress of MSC experimental research as well as human clinical trials for neural and retinal diseases.This review article will focus on multiple sclerosis,spinal cord injury,autism,glaucoma,retinitis pigmentosa and age-related macular degeneration. | Tsz Kin Ng Veronica R Fortino Daniel Pelaez Herman S Cheung | 2014 | World Journal of Stem Cells2014，6，2： | 13 |
| 2 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez Ramos J Song S Cardozo Pelaez F | | 0，，： | 2 |
| 3 | Pelvicfloor muscle training included in a pregnancy exercise program is effective in primary prevention of urinary in- continence: a randomized controlled trial 显示文摘 | Pelaez M Gonzalez-Cerron S Montcjo R | 2014 | Neurourol Urodyn2014，33，1： | 1 |
| 4 | A new measure of consistency for positive reciprocal matrices 显示文摘 | Pelaez J I Lamata M T | 2003 | Computers and Mathematics with Applications2003，46，9： | 1 |
| 5 | Efficacy of oral ribavirin in lung transplant patients with respiratory syncytial virus lower respiratory tract infection显示文摘 | Pelaez A Lyon GM Force SD | 2009 | Heart Lung Transplant2009，8，1： | 1 |
| 6 | Adult bone marrow stromal cells differentiate into neural cells in vivo显示文摘 | Sanchez - Ramos J Song S Cardozo - Pelaez F | 2000 | Exp Neurol2000，164，： | 1 |
| 7 | Workload due to Aspergillus fumigatus and significance of the organism in the microbiology laboratory of a general hospital 显示文摘 | Bouza E Guinea J Pelaez T | 2005 | J Clin Micro- biol2005，43，5： | 1 |
| 8 | Plasticity of stem cells derived from adult periodontal ligament 显示文摘 | Huang CY Pelaez D Dominguez-Bendala J | 2009 | Regen Med2009，4，6： | 1 |
| 9 | Effect of heat treatment on the proteolytic activity of mesophilic bacteria isolated from goat's milk cheese显示文摘 | Asensio C Gomez R Pelaez C | 1995 | Applied Microbiology1995，21，1： | 1 |
| 10 | Endophytic fungi from plants living on gypsum soils as a source of secondary metabolites with antimicrobial activity显示文摘 | Collado J Arenal F | 1998 | Mycological Res1998，102，6： | 1 |
| 11 | Development of an assay to assess the functional integrity of the humtm sperm membrane and its relationship to other sperm characteristics 显示文摘 | JEYENDRAN R S VanDERVEN H H PELAEZ M | 1984 | J Reprod Fert1984，70，： | 1 |
| 12 | Intracellular and extracellular calcium utilization during hypoxic vasoconstriction of cyclostome aortas显示文摘 | Russell MJ Pelaez NJ Packer CS | 2001 | Am J Physiol2001，281，5： | 1 |
| 13 | Pathologic prostate cancer characteristics in patients eligible for active surveillance: a head-to-head comparison of contemporary protocols显示文摘 | IREMASHVILI V PELAEZ L MANOHARAN M | 2012 | Eur Urol2012，62，3： | 1 |
| 14 | Use of heat-shocked mesophilic lactic acid bacteria in low-fat goat's milk cheesemaking 显示文摘 | Asensio C Parra L Pelaez C | 1996 | Journal of Agricultural and Food Chemistry1996，44，9： | 1 |
| 15 | In vitro antifungal ac-tivities of isavuconazole ( BAL4815 ),voriconazole, and flucon-azole against 1,007 isolates of zygomycete,Candida,aspergil-lus,fusarium,and scedosporium species 显示文摘 | GUINEA J PELAEZ T RECIO S | 2008 | Antimicrob AgentsChemother2008，52，4： | 1 |
| 16 | Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial-mesenchymal transition in colorectal carcino- ma cells显示文摘 | Pelaez 1M Kalogeropoulou M Ferraro A | 2010 | Int J Biochem Cell Bioi2010，42，6： | 1 |
| 17 | Specificity of the bound and free forms of the cell- envelope proteinase of Lactobacillus caseisubsp, casei IFPL 731 towards the, α-easein-(I-23)-fragment 显示文摘 | FERNANDEZ de PALENCIA P PELAEZ C P MARTINHERNANOEH M C | 1997 | Letters in Applied Microbiology1997，25，： | 1 |
| 18 | Immune thrombocytopenic purpura due to disseminated tuberculosis显示文摘 | Hernandez-Maraver D Pelaez J Pinilla J | 1996 | Acta Haematol1996，96，4： | 1 |
| 19 | Majority additive - ordered weighting avera- ging: a new neat ordered weighting averaging operator based on the majority process 显示文摘 | PELAEZ J I DONA J M | 2003 | International Journal of Intelligent Systems2003，18，4： | 1 |
| 20 | Caseinomacropeptide and whey protein concentrate enhance Bifidobacterium lactis growth in milk显示文摘 | Janer C Pelaez C Requena T | 2004 | Food Chem2004，86，2： | 1 |
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