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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation显示文摘AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA parameters.RESULTS: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P < 0.05; Kendall’s tau b = 0.36, P < 0.05, respectively). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P < 0.05). CONCLUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants. | Samuel C Lüthold Mascha K Rochat Peter Bhler | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 3 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 4 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 5 | Direct inhibition of methanogenesis by ferric iron 显示文摘 | Peter M B Johannes C M S Alfons J M S | 2004 | FEMS Microbiology Ecology2004，49，： | 1 |
| 6 | Surface pH measurements during nickel electrodeposition 显示文摘 | JI J COOPER W C DREISINGER D B PETERS E | 1995 | Journal of Applied Electrochemistry1995，25，7： | 1 |
| 7 | Effect of the antihypertensive drug hydralazine on mineral metabolism in the rat显示文摘 | Keen C L Peters J M Lonnerdal B | 1988 | Toxicol Lett1988，41，3： | 1 |
| 8 | Therapy for pancreatic cancer with a recombinant humanizied antibody anti-HER2(Hercepitin) 显示文摘 | Peter B Howard A Mannuela C | 2001 | J Gastrointestinal Surgery2001，31，5： | 1 |
| 9 | Shock tube pyrolysis of pyridine显示文摘 | John C Mackie Meredith B ColketⅢ Peter F Nelson | 1990 | J Phys Chem1990，94，10： | 1 |
| 10 | Novel immunoregulatory functions of phenotypically distinct subpopulations of CD4^+ cell in the human neonate显示文摘 | Loran T C Peter E V Georgienne E B | 1990 | J Immun1990，145，3： | 1 |
| 11 | Outcomes of lumbar to sacral nerve rerouting for spina bifida 显示文摘 | Peters KM Girdler B Turzewski C | 2010 | Journal of Urology2010，184，2： | 1 |
| 12 | Stabilization and Preser- vation of Lactobacillus Acidophilus in Saccharide Matrices显示文摘 | PAUL B C MILLER D P PETER R C | 2000 | Cryobiology2000，41，1： | 1 |
| 13 | Copper isotope ratios in magmatic and hydrothermal ore-forming environments显示文摘 | Peter B Larson Kierran Maher Frank C Ramos Zhaoshan Chang Miguel Gaspar Lawrence D Meinert | 2003 | Chemical Geology2003，，3： | 1 |
| 14 | Shock tube pyrolysis of pyrrole and kinetics modelling显示文摘 | John C Mackie Meredith B ColketⅢ Peter F Nelson | 1991 | Int J Chem Kinet1991，23，8： | 1 |
| 15 | A single copy of virus- derived transgene encoding hairpin RNA gives immunity to barley yellow dwarf virus显示文摘 | Wang M B David C A Peter M W | 2000 | Molecular plant pathology2000，1，6： | 1 |
| 16 | Kinetics of the reactions of CF3O2 with OH, HO2 and H显示文摘 | Peter B Carlos E C Dudley E S | 1997 | J Chem Soc Faraday Trans1997，93，16： | 1 |
| 17 | Earliest gestational age for fetal sexing in cell-free maternal plasma显示文摘 | Rijnders R J van der Luijt R B Peters E D Goeree J K Van Der Schoot C E Ploos Van Amstel J K | 2003 | Prenat Diagn2003，23，： | 1 |
| 18 | Chicken anemia vinis VP2 is a novel dual specificity protein phosphatase显示文摘 | Peters M A Jackson D C Crabb B S | 2002 | Biol Chem2002，277，39： | 1 |
| 19 | Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits 显示文摘 | Peter J B Barnard R J Edgerton V R Gillespie C A Stemple K E | 1972 | Biochemistry1972，11，： | 1 |
| 20 | Consensus Proposals for a Unified System ofNomenclature of Hepatitis C Virus Genotypes显示文摘 | Peter S Jens B Christophe C | 2005 | HEPATOLOGY2005，42，2： | 1 |
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