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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Targeting TGF-beta overexpression:maximizing the antifibrotic actions of angiotensin Ⅱ blockade in anti-Thy1 glomerulonephritis显示文摘 | PETERS H BORDER W A NOBLE N A | 1999 | Nephrol Dial Transplant1999，14，4： | 1 |
| 3 | Meta - a- nalysis of MR imaging in the diagnosis of breast lesions 显示文摘 | Peters N H Borel Rinkes I H Zuithoff N P | 2008 | Radiology2008，246，1： | 1 |
| 4 | A software-based highquality MPEG-2 encoder employing scene change detection and adapfve quantization显示文摘 | DIRK F NIELS M PETER H N | 2001 | IEEE ICCE Digest2001，，： | 1 |
| 5 | Bayesian network model for reliability assessment of power systems 显示文摘 | David C Y Thanh C N Peter H | 1999 | IEEE Trans on Power Systems1999，14，2： | 1 |
| 6 | 3D reconstruction of the carotid artery from two views using a single centerline显示文摘 | Kenneth R H Alan M W Peter B N | 2004 | International Congress Series2004，，： | 1 |
| 7 | Coal liquefaction, Shenhua Group, and Chinas energy security显示文摘 | Peter N Alan S Rui H C | 2004 | European Management Journal2004，22，2： | 1 |
| 8 | SAMPEG,a scene adaptive,parallel MPEG-2 software encoder 显示文摘 | DIRK F NIEIS M PETER H N | 2001 | SPIE Visual Communications and Image Processing2001，43，10： | 1 |
| 9 | Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species显示文摘 | PEDERSEN S N PEDERSEN K L PETER H | 1996 | Biochem J1996，319，： | 1 |
| 10 | Mixing models for the two-way-coupling of CFD codes and zero-dimensional multizonecodes to model HCCI combustion显示文摘 | H Batths C Felseh N Peters | 2009 | Combustion and Flame2009，156，： | 1 |
| 11 | Upregulation of Connexin43 Gap Junctions during Early Stages of Human Coronary Atheroselerosis显示文摘 | Blackburn J P Peters N S Yeh H I | 1995 | Arterioscler Thromb Vasc Biol1995，15，8： | 1 |
| 12 | The yield gap of global grain production: A spatial analysis显示文摘 | Kathleen N Peter H V Elke S | 2010 | Agricultural Systems2010，103，5： | 1 |
| 13 | Nucleosides in sow colostnuns and milk at different stages of lactation显示文摘 | Mateo C D Peters D N Stein H H | 2004 | J Amin Sci2004，82，： | 1 |
| 14 | Unsteady flamelet modeling of soot formation in turbulent diffusion flames 显示文摘 | Pitsch H Riesmeier E Peters N | 2000 | Combustion Science and Technology2000，158，： | 1 |
| 15 | Towards tailored therapy of glioblastoma multiforme显示文摘 | Rekers N H Sminia P Peters G J | 2011 | J Chemother2011，23，4： | 1 |
| 16 | Pax1 and Pax9 syner- gistically regulate vertebral column development显示文摘 | Peters H Wilm B Sakai N | 1999 | De veloprnent1999，126，23： | 1 |
| 17 | Impact of urinary incontinence after stroke:results from a prospective population-based stroke register显示文摘 | Peter L Max-Josef H Bernhard N | 2003 | Neurology and Urodynamics2003，22，： | 1 |
| 18 | Eigenfaces vs Fisherfaces: recognition using class specific linear projec- tion 显示文摘 | PETER N B JOAO P H DAVID J K | 1997 | IEEE Trans on Pattern Analysis and Machine In- telligence1997，19，7： | 1 |
| 19 | Green fluorescent protein as a quantitative tool显示文摘 | Nicola J Hack Brian Billups Peter B Guthrie John H Rogers Elizabeth M Muir Thomas N Parks Stanley B Kater | 2000 | Journal of Neuroscience Methods2000，，2： | 1 |
| 20 | Effects of silicon level on rate,quality and progession of bone healing within silicate-substituted porous hydroxyapatite scaffolds显示文摘 | Karin A H Peter A R Smith N | 2006 | Biomaterials2006，29，27： | 1 |
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