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| 1 | Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer显示文摘AIM To investigate the impact of thymidylate synthase(TYMS), KRAS and BRAF in the survival of metastatic colorectal cancer(m CRC) patients treated with chemotherapy. METHODS Clinical data were collected retrospectively from records of consecutive patients with m CRC treated with fluoropyrimidine-based chemotherapy from 1/2005 to 1/2007. Formalin-fixed paraffin-embedded tissues were retrieved for analysis. TYMS genotypes were identified with restriction fragment analysis PCR, while KRAS and BRAF mutation status was evaluated using real-time PCR assays. TYMS gene polymorphisms of each of the 3' untranslated region(UTR) and 5'UTR were classified into three groups according to the probability they have for high, medium and low TYMS expression(and similar levels of risk) based on evidence from previous studies. Univariate and multivariate survival analyses were performed.RESULTS The analysis recovered 89 patients with m CRC(46.1% de novo metastatic disease and 53.9% relapsed). Of these, 46 patients(51.7%) had colon cancer and 43(48.3%) rectal cancer as primary. All patients were treated with fluoropyrimidine-based chemotherapy(5FU or capecitabine) as single-agent or in combination with irinotecan or/and oxaliplatin or/and bevacizumab. With a median follow-up time of 14.8 mo(range 0-119.8), 85 patients(95.5%) experienced disease progression, and 63 deaths(70.8%) were recorded. The 3-year and 5-year OS rate was 25.4% and 7.7% while the 3-year progression-free survival rate was 7.1%. Multivariate analysis of TYMS polymorphisms, KRAS and BRAF with clinicopathological parameters indicated that TYMS 3'UTR polymorphisms are associated with risk for disease progression and death(P < 0.05 and P < 0.03 respectively). When compared to tumors without any del allele(genotypes ins/ins and ins/loss of heterozygosity(LOH) linked with high TYMS expression) tumors with del/del genotype(low expression group) and tumors with ins/del or del/LOH(intermediate expression group) have lower risk for disease progression(HR = 0.432, 95%CI: 0.198-0.946, P < 0.04 and HR = 0.513, 95%CI: 0.287-0.919, P < 0.03 respectively) and death(HR = 0.366, 95%CI: 0.162-0.827, P < 0.02 and HR = 0.559, 95%CI: 0.309-1.113, P < 0.06 respectively). Additionally,KRAS mutation was associated independently with the risk of disease progression(HR = 1.600, 95%CI: 1.011-2.531, P < 0.05). The addition of irinotecan in 1st line chemotherapy was associated independently with lower risk for disease progression and death(HR = 0.600, 95%CI: 0.372-0.969, P < 0.04 and HR = 0.352, 95%CI: 0.164-0.757, P < 0.01 respectively).CONCLUSION The TYMS genotypes ins/ins and ins/LOH associate with worst prognosis in m CRC patients under fluoropyrimidine-based chemotherapy. Large prospective studies are needed for validation of our findings. | Anastasios Ntavatzikos Aris Spathis Paul Patapis Nikolaos Machairas George Peros Stefanos Konstantoudakis Danai Leventakou Ioannis G Panayiotides Petros Karakitsos Anna Koumarianou | 2017 | World Journal of Gastroenterology2017，23，32： | 4 |
| 2 | 分娩所致Valsalva视网膜病变治疗方法的探讨(英文)显示文摘目的:讨论孕妇Valsalva视网膜病变保守或手术治疗方法的选择。方法:一健康孕妇在自然阴道分娩时,右眼底发生黄斑前玻璃体后界膜下出血,本文报道其保守治疗的效果。结果:右眼发病3wk时积血收缩,视力为眼前手动,但病程6mo时,积血溶解,视力恢复至6/5。结论:大多数Valsalva视网膜病变能够自愈。对一些难治性病例,采用Nd:YAG激光行内界膜切开具有一定的效果。而早期玻璃体切除术的增殖膜切除,对预防眼底新生血管膜的发生也具有一定的效果。 | Konstantinos I Papageorgiou Rashmi G Mathew AlexanderS Ioannidis Ajay Sinha Petros S Andreou | 2007 | 国际眼科杂志2007，7，3： | 3 |
| 3 | Source Apportionment of Urban Particulate Aliphatic and Polynuclear Aromatic Hydrocarbons(PAHs) Using Multivariate Methods 显示文摘 | Ilias G K Petros K Manolis T | 2001 | Environmental Science & Technology2001，35，： | 2 |
| 4 | Factors influencing postoperative urinary retention in patients undergoing surgery for benign anoreetal disease显示文摘 | Petros J G Bradley T M | 1994 | Am J Surg1994，159，4： | 1 |
| 5 | The calcitic marble/water interface: kinetics of dissolutionand inhibition with potential implications in stone conservation显示文摘 | Dimirtra G Kanellopoulou Petros G Koutsoukos | 2003 | Langmuir2003，19，： | 1 |
| 6 | surgically treated acetabular fractures via a simple posterior approach with a followup of 2-10 years 显示文摘 | Petsatodis G Petros A Chalidis B | 2007 | Injury care Infused2007，38，33： | 1 |
| 7 | Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells显示文摘 | Salvi A Arici B De Petro G | 2004 | Mol Cancer Ther2004，3，6： | 1 |
| 8 | Clear-cut complete rup- ture of origin of right main bronchus 显示文摘 | Petros TM Konstantinos P Joannis G | 2008 | Asian cardiovas Thorac Ann2008，16，1： | 1 |
| 9 | Evaluation of a safe male circumcision training programme for traditional surgeons and nurses in the Easten Cape, South Afire显示文摘 | Peltzer K Nqeketo A Petros G | 2008 | Afr J Tradit Complement Altern Med2008，5，4： | 1 |
| 10 | Color Doppler ultrasound(CDU) of normal and abnormal testes显示文摘 | Petros J A Andriole G L Kvoussi L R | | 0，，： | 1 |
| 11 | Quantitative bacteriology in wound care 显示文摘 | Shulman G Petro JA Hallgren EH | 1979 | Am Surg1979，45，： | 1 |
| 12 | Precipitation of calcium carbonate in aqueous solutions in the presence of oxalate anions 显示文摘 | EFTHIMIOS K G PETROS G K | 1988 | Langmuir1988，4，4： | 1 |
| 13 | A solution to the unit-commitment problem using interger-coded genetic algorithm显示文摘 | IOANNIS G DAMOUSIS ANASTASIOS G BAKIRTZIS PETROS S DOKOPOULOS | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
| 14 | Correlation of testicular color Doppler uhrasonography, physical examination and venography in detection of left varieoeele men with infertility显示文摘 | Petros J Andriole G Middleton W | 1991 | J Urol1991，145，： | 1 |
| 15 | Modelling of water pollution in the thermalos gulf with fuzzy praameters 显示文摘 | Herclues M Petro A Jacques G | 2001 | Ecological Modelling2001，142，12： | 1 |
| 16 | Efficacy of liposomes and hyperthermia in a human tumor xenograft model:importance of triggered drug release显示文摘 | KONG G ANYARAMBHATLE G PETRO WP | 2000 | Cancer Res2000，60，24： | 1 |
| 17 | Geometric tolerance evaluation: a discussion on minimum zone fitting algorithms 显示文摘 | Moroni G Petro S | 2008 | Precision Engineering2008，，32： | 1 |
| 18 | Solution structure of the antiapoptotic protein bcl-2 显示文摘 | Petros A M Medek A Nettesheim D G | 2001 | Proc Natl Acad Sci U S A2001，98，6： | 1 |
| 19 | Role of leptin in fat regulation显示文摘 | Collins S Kuhn G M Petro A E | 1996 | Nature1996，380，： | 1 |
| 20 | Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells显示文摘 | Arici B De Petro G | 2004 | Mol Cancer Ther2004，3，6： | 1 |
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