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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | A cross-sectional survey to evaluate knowledge ,attitudes and practices(KAP) regarding seasonal influenzavaccination among European travellers to resource-limited destina-vaccination among European travellers to resource-limited destina- tions显示文摘 | Pfeil A Miitsch M Hatz C | 2010 | BMC Public Health2010，10，7： | 1 |
| 3 | Fatigue life estimatesfor a slender orthotropic steel deck显示文摘 | Battista R C Pfeil M S Carvalho E M L | 2008 | Journal of ConstructionalSteel Research2008，64，1： | 1 |
| 4 | Reduction of vortex-induced oscillations of Rio-Niteroi Bridge by dynamic control devices 显示文摘 | BATTISTA R C PFEIL M S | 2000 | Journal of Wind Engineering and Industrial Aerodynamics2000，84，： | 1 |
| 5 | Establishing remission and good clinical functioning in schizophrenia:Predictors of best outcome with long-term risperidone long-acting injectable treatment显示文摘 | Lambert M Marinis T D Pfeil J | 2010 | European Psychiatry2010，25，4： | 1 |
| 6 | Dynamic behavior and stability of transmission line towers under wind forces显示文摘 | Battisa R C Rodfignes R S Pfeil M S | 2003 | J Wind Eng and Ind Aerodyn2003，91，8： | 1 |
| 7 | Stress Concentration in Steel Bridge Orthotropic Decks 显示文摘 | PFEIL M S BATrlSTA R C MERGULH_AO A J R | 2005 | Journal of Constructional Steel Research2005，61，8： | 1 |
| 8 | Dynamic behavior and stability of transmission line towers under wind forces显示文摘 | Battista R C Rodrigues R S Pfeil M S | 2003 | Jour nal of Wind Engineering and Industrial Aerodynamics2003，91，8： | 1 |
| 9 | Stress Concentration in Steel Bridge Orthotropic Decks显示文摘 | Pfeil M S Battista R C Mergulho A J R | 2005 | Journal of Constructional Steel Research2005，61，8： | 1 |
| 10 | Reduction of vortex-induced oscillations of Rio-niteroi Bridge by dynamic control devices显示文摘 | Battista R C Pfeil M S | 2000 | Journal of Wind Engineering and Industrial Aerodynamics2000，84，3： | 1 |
| 11 | Influence of ammonia borane on the stability of a liquid rocket combustor显示文摘 | PFEIL M A SON S F ANDERSON W E | 2014 | Journal of Propulsion and Power2014，30，2： | 1 |
| 12 | Dynamic behavior and stability of transmission line towers under wind forces 显示文摘 | BATTISTA R C RODRIGUES R S PFEIL M S | 2003 | Journal of Wind Engineering and Industrial Aerodynamics2003，91，8： | 1 |
| 13 | Dynamic behavior and sta-bility of transmission line towers under wind forces显示文摘 | Battista R C Rodrigues R S Pfeil M S | 2003 | Journal ofWind Engineering and Industrial Aerodynamics2003，91，8： | 1 |
| 14 | Dynamic behavior and stability of transmission line towers under wind forces显示文摘 | Battista R C Rodrigues R S Pfeil M S | 2003 | Journal of Wind Engineering and Industrial Aerodynamics2003，，91： | 1 |
| 15 | Caught redhanded:Rc encodes a basic helix-loop-helix protein conditioning red pericarp in riee显示文摘 | Sweeney M T Thomson M J Pfeil B E | 2006 | The Plant Cell2006，18，： | 1 |
| 16 | Fatigue life estimates for a slender orthotropic steel deck 显示文摘 | Ronaldo C Battista Michele S Pfeil Eliane M L Carvalho | 2008 | Journal of Constructional Steel Research2008，64，： | 1 |
| 17 | Intermedin (ad- renomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothe- lial cell monolayers显示文摘 | ASLAM M PFEIL U GUNDUZ D | 2012 | Br J Pharmacol2012，165，1： | 1 |
| 18 | Power source roadmaps using bibliometrics and database tomography 显示文摘 | Kostoff R N Tshiteya R Pfeil K M | 2005 | Energy2005，30，5： | 1 |
| 19 | Dynamic behavior and stability of transmission line towers under wind forces显示文摘 | Battista R C Rodrigues R S Pfeil M S | 2003 | Journal of Wind Engineering and Industrial Aerodynamics2003，91，8： | 1 |
| 20 | Reduction of vortex-induced oscilla- tions of Rio-Niteroi bridge by dynamic control devices 显示文摘 | Battista R C Pfeil M S | 2000 | Journal of Wind Engineering and Industry Aerodynamics2000，84，： | 1 |
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