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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | CLIP-170 links endocytic vesicles to microtubules显示文摘 | Pierre P Scheel J Rickard J E | 1992 | Cell1992，70，6： | 1 |
| 3 | Retiform haeman- gioendothelioma 显示文摘 | Dufau J P Pierre C De Saint Maur P P | 1997 | Ann Pathol1997，17，1： | 1 |
| 4 | Ischemic stroke in patients under age 45显示文摘 | Bogousslavssky J Pierre P | 1992 | Neurol Clin1992，10，： | 1 |
| 5 | RnKSN, a floral repressor, forms protein complexes with RoFD and RoFT to regulate vegetative and reproductive development in rose 显示文摘 | RANDOUX M DAVIERE J M JEAUFFRE J THOUROUDE T PIERRE S TOUALBIA Y PERROTTE J REYNO1RD J P JAMMES M J HIBRAND-SAINT OYANT L FOUCHER F | 2014 | New Phytologist2014，202，1： | 1 |
| 6 | Ischemic stroke in patients under age 45 显示文摘 | Bogousslavsky J Pierre P | 1992 | Neurol Clin1992，10，1： | 1 |
| 7 | Schemic stroke in patients under age 45显示文摘 | Pierre P | 1992 | Neurol Clin1992，10，： | 1 |
| 8 | Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity显示文摘 | PIERRE M ONGE S JONES P J H | 2002 | The American Society for Nutritional Sciences: Journal of Nutrition2002，132，： | 1 |
| 9 | New butenolides in plantlets of Virola surinamensis (Myristicaceae) 显示文摘 | NORBERTO P L PIERRE A D S MASSUO J K | 2004 | Chem Pharm Bull2004，52，10： | 1 |
| 10 | MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain 显示文摘 | Pierre K Magistretti P J Pellerin L | 2002 | Cereb Blood Flow Metab2002，22，5： | 1 |
| 11 | Arthroscopy of the elbow 显示文摘 | Andrews J R Pierre P K Carson W G | 1986 | Clin Sports Med1986，5，： | 1 |
| 12 | Ischemic stroke in patients under age 45显示文摘 | Bogousslavssky J Pierre P | 1992 | Neurol Clin1992，10，1： | 1 |
| 13 | Influence of heatand refining on formation of CLA isomers in sunflower oil显示文摘 | PIERRE J STEPHANIE B P JEAN-LOUIS S | 2003 | Journal ofthe American Oil Chemists Society2003，80，9： | 1 |
| 14 | Ischem ic stroke in pa- tients under age 45显示文摘 | Bogousslavssky J Pierre P | 1992 | Neurol Clin1992，10，： | 1 |
| 15 | Ischemic stroke in padents under age 45显示文摘 | Bogousslavsky J Pierre P | 1992 | Neurol Clin1992，10，： | 1 |
| 16 | Syndesmosis sprains of the ankle显示文摘 | HopkinsonW J St Pierre P Ryan J B | 1990 | FootAnkle1990，10，： | 1 |
| 17 | (Z)-Tamoxifen and tetrasubstituted Alkenes and Dienes via a region-and stereospecific three-component magnesium carbometalation palladium(o) cross-coupling strategy显示文摘 | Pierre E T Andrea J P Fabio E S and Alex G F | 2003 | 5(17):2989-29922003，5，17： | 1 |
| 18 | Quantitative DSC evaluation of phase segregation rate in linear segmented polyurethanes and polyurethaneureas显示文摘 | Pierre P J C Yves | 1983 | Journal of Polymer Science: Polymer Chemistry Edition1983，21，： | 1 |
| 19 | Angiotensin Ⅱ activates Collagen Type I Gene in the Renal Vasculature of Transgenic Mice During Inhibition of Nitric Oxide Synthesis显示文摘 | Jean - J B Pierre - L T Sandrine P | 1999 | Circulation1999，100，： | 1 |
| 20 | Extrinsic Magnetoresistance in Bulk Sintered Manganites显示文摘 | Nossov A Pierre J Strobel P | 1999 | Journal of Magnetism and Magnetic Materials1999，，： | 1 |
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