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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 4 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004，7，5： | 2 |
| 5 | Potential for habituation to a neembased feeding deterrent in Japanese beetles,Popillia japonica显示文摘 | Held D Eaton T Potter D | 2001 | Entomologia Experimentalis et Applicata2001，101，1： | 1 |
| 6 | Links between climate and sea levels for the past three million years 显示文摘 | Lambeck K Esat T M Potter E K | 2002 | Nature2002，419，： | 1 |
| 7 | 查看详情显示文摘 | Potter A R Baker R T | | 0，，19： | 1 |
| 8 | Accuracy of sonographic localization and specimen ultrasound performed by surgeon sin impalpable screen-detected breast lesion显示文摘 | Potter S Govindarajulu S Caw T | | Breast0，，4： | 1 |
| 9 | A quality and efficiency analysis of the IMFAST se~nentation algorithm in head and neck 'step & shoot' IMRT treatment 显示文摘 | POTTER L D CHANG S X CULLIP T J | 2002 | Med Phys2002，29，3： | 1 |
| 10 | Akt regulates growth by directly phosphorylating Tsc2 显示文摘 | Potter C J Pedraza LG Xu T | 2002 | Nat Cell Biol2002，4，9： | 1 |
| 11 | CHl-IIPS(Controlling Hypertension and I-Iypotension Immediately Post-Stroke)Pilot Trial: rationale and desigaa 显示文摘 | Potter J Robinson T Ford G | 2005 | J Hypertens2005，23，： | 1 |
| 12 | Links between cli-mate and sea levels for the past three million years 显示文摘 | Lambeck K Esat T M Potter E K | 2002 | Nature2002，419，6903： | 1 |
| 13 | Salmonella vaccines in poultry: past, present and future显示文摘 | Desin T S K6ster W Potter A A | 2013 | Expert Rev Vaccines2013，12，1： | 1 |
| 14 | Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway显示文摘 | Cheung T C Humphreys I R Potter K G | 2005 | Proc Natl Acad Sci USA2005，102，13： | 1 |
| 15 | Terrestrial ecosystem production :a process model based on globe satellite and surface data 显示文摘 | Potter C S Randerson J T Field C B | 1993 | Globe Biogeochemical Cycle1993，7，4： | 1 |
| 16 | Akt regulates growth by directly phosphorylating Tsc2显示文摘 | POTTER C J PEDRAZA L G XU T | 2002 | Nature Cell Biology2002，4，9： | 1 |
| 17 | IRC-Flanders and maredflow显示文摘 | DE POTTER B STASSIJNS F DE ROECK T | 2006 | Flanders Marine Institute Special Publication2006，，29： | 1 |
| 18 | Modelling of the spring-in phenomenon in curved parts made of a thermosetting composite显示文摘 | Ersoy N Garstka T Potter K Wisnom M R Porter D Stringer G | 2010 | Composites Part A: Applied Science and Manufacturin2010，41，3： | 1 |
| 19 | Left ventricular systolic dysfunction by itself does not influence outcome of atrial fibrillation ablation显示文摘 | De Potter T Berruezo A Mont L | 2010 | Europace2010，12，1： | 1 |
| 20 | Fasteners for composite structures 显示文摘 | Code R T Batch E J Potter J | 1982 | Composite1982，13，23： | 1 |
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