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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Transgenic expression of pear PGIP in tomato limits fungal colonization 显示文摘 | Powell A L T van Kan J ten Have A | 2000 | Molecular Plant-Microbe Interaction2000，13，： | 1 |
| 4 | Improved classification of conservation tillage adoption using high temporal and synthetic satellite imagery显示文摘 | Watts J D Powell S L Lawrence R L | 2011 | Remote Sensing of Environment2011，115，1： | 1 |
| 5 | A Strain-rate-dependent concrete material model for ADINA显示文摘 | Tedesco J W Powell J C Ross C Hughes M L | 1997 | Computers & Structures1997，64，56： | 1 |
| 6 | A new device to limit extravasa-tion during contrast-enhanced CT显示文摘 | Powell C C Li J M Rodino L | 2000 | AJR Am J Roentgenol2000，174，2： | 1 |
| 7 | Pharmacologic studies on radix puerariae: effect of puerarin on regional yocardial blood flow and cardiac hemodynamics in dogs with acute myocardial isochemia显示文摘 | Fan L L O'Keefe D D Powell W W J | 1985 | Chin Med J1985，98，： | 1 |
| 8 | Synthesis of metastable epitaxial zhc-blende-structure AIN by solid-state reaction显示文摘 | PETROV I MOJAB E POWELL R C GREEN J E HULTMAN L SUNDGREN J E | 1992 | Appl Phys Lett1992，60，： | 1 |
| 9 | Phosphomannose isomerase:an efficient selectable marker for plant transformation显示文摘 | Reed J Privallel L Powell M L Meghji M Dawson J Dunder E Suttie J Wenck A Launis K Kramer C Chang Y F Hansen G Wright M | | 0，，： | 1 |
| 10 | The lateral organ boundaries domain transcription factor LBD20 functions in fu- sarium wilt susceptibility and jasmonate signaling in Arabidopsis显示文摘 | THATCHER L F POWELL J J AITKEN E A | 2012 | Plant Physiology2012，160，1： | 1 |
| 11 | Pristane/phytane ratio as environmental indicator:Discussion and reply显示文摘 | Powell T G ten Haven H L Rullkeetter J de Leeuw J W and Damste J S S | | 0，，6174： | 1 |
| 12 | Gender and DSS design: The research implications 显示文摘 | Powell P L Johnson J E V | 1995 | Decision SupportSystems1995，14，1： | 1 |
| 13 | Palmoplantar keratoderma and skin grafting:postsurgical long-term follow-up of two cases with Olmsted syndrome显示文摘 | Bédard MS Powell J Laberge L | 2008 | Pediatr Dermatol2008，25，2： | 1 |
| 14 | Adoptive immunotherapy for cancer:building on success显示文摘 | Gattinoni L Powell D J Jr Rosenberg S A | 2006 | Nat Rev Immunol2006，6，5： | 1 |
| 15 | Release of necrosis factor alpha in response to Vibrio vilnificus caosular polysaccharide in viro and in vitro model 显示文摘 | Powell J L Wright A C Wasserman S S | 1997 | Infect Immure1997，65，9： | 1 |
| 16 | Inflammatory cytokine response to Vibrio vulnifieus elicited by peripheral blood monoclear cells from chronic alcohol users is associated with biomarkers of cellular oxidative stress 显示文摘 | Powell J L Strauss K A Wiley C | 2003 | Infect Immunity2003，71，7： | 1 |
| 17 | Dairy diet phosphorus effects on phosphorus losses in runoff from land - application manure 显示文摘 | Ebeling A M Bundu L G Powell J M | 2002 | Soil Sci Soe Am J2002，66，： | 1 |
| 18 | BSACI guidelines for the management of chronic urtieuria and angio-oedema 显示文摘 | Powell R J Du-Toit G L Siddique N | 2007 | Clin Exp Allergy2007，37，5： | 1 |
| 19 | Early results of external iliac artery stenting combined with com- mon femoral artery endarterectomy 显示文摘 | Nelson P R Powell R J Schermerhorn M L | 2002 | J Vasc Surg2002，35，6： | 1 |
| 20 | Clarithromycintargets neutrophilic airway inflammation in refractory asthma 显示文摘 | SIMPSON J L POWELL H BOYLE M J | 2008 | Am J Respir Crit Care Med2008，177，1： | 1 |
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