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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 3 | Filterbank-based fingerprint matching 显示文摘 | ANIL K JAIN SALIL PRABHAKAR LINHONG SHARATH PANKANTI | 2000 | IEEE Trans On Image Processing2000，9，5： | 1 |
| 4 | An Introduction to Biometric Recognition 显示文摘 | ANIL K JAIN ARUN ROSS SALIL PRABHAKAR | 2004 | IEEE Transactions on Circuits and Systems for Video Technology2004，14，1： | 1 |
| 5 | Synthesis and QSAR studies on thiazolidinones as anti-HIV agents 显示文摘 | Rawal R K Solomon V R Prabhakar Y S | 2005 | Comb Chem High Throughput Screen2005，8，5： | 1 |
| 6 | An introduction to biometricrecognition显示文摘 | Jain A K Ross A Prabhakar S | 2004 | IEEE Transactions on Circuits and Systems forVideo Technology2004，14，1： | 1 |
| 7 | An introduction to biometric recognition显示文摘 | JAIN A K ROSS A PRABHAKAR S | 2004 | IEEE Transactions on Circuits and Systems for Video Technology2004，14，1： | 1 |
| 8 | Postoperative analgesia in children when using clonidine or fentanyl with ropivacaine given caudally 显示文摘 | Shukla U Prabhakar T Malhotra K | 2011 | Anaesthesiol Clin Pharmacol2011，27，2： | 1 |
| 9 | Biometric recognition:Secur-ity and privacy concerns 显示文摘 | Prabhakar S Pankanti S Jain A K | 2003 | IEEE Security Privacy2003，1，2： | 1 |
| 10 | 2-(Aryl)- 3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors显示文摘 | Rawal R K Prabhakar Y S Katti S B | 2005 | Bioorg Med Chem2005，13，24： | 1 |
| 11 | Biological activity of phenylpropionic acid isolated from a terrestrial Streptomycetes显示文摘 | Narayana K J Prabhakar P Vijayalakshmi M | 2007 | Polish Journal of Microbiology2007，56，3： | 1 |
| 12 | An introduction to biometric recognition 显示文摘 | Anil K Jain Arun Ross Salil Prabhakar | 2004 | IEEE Transactions on Circuits and System forVideoTechnology(S1051-8215)2004，14，1： | 1 |
| 13 | Evaluation of serum vascular endothelial growth factor(VEGF) and microvessel density (MVD) as prognostic indicators in carcinoma breast 显示文摘 | Shivakumar S Prabhakar BT Jayashree K | 2009 | Cancer Res Clin Oncol2009，135，4： | 1 |
| 14 | Filterbank-based fingerprint matching显示文摘 | Jain A K Prabhakar S Hong L | 2000 | IEEE Transactions on Image Processing2000，9，5： | 1 |
| 15 | An introduction to biometric recognition 显示文摘 | JAIN A K ROSS A PRABHAKAR S | 2004 | IEEE Transactions on Circuit and System for VideoTechnology2004，14，1： | 1 |
| 16 | Bacopa monniera alleviates N (omega)-nitro-L-arginine arginine-induced but not MK-801-induced amnesia:a mouse Morris watermaze study显示文摘 | Saraf M K Prabhakar S Anand A | 2009 | Neuroscience2009，160，1： | 1 |
| 17 | Decision-level Fusion in Fingerprint Verification显示文摘 | Prabhakar S Jain A K | 2002 | Pattern Recognition2002，35，4： | 1 |
| 18 | An Introduction to Bio-metric Recognition 显示文摘 | Jain A K Ross A Prabhakar S | 2004 | IEEE Transactions on Circuitsand Systems for Video Technology2004，14，1： | 1 |
| 19 | An Introduction to Biometric Recognition 显示文摘 | JAIN K ROSS A PRABHAKAR S | 2004 | IEEE Transactions on Circuits and Systems for Video Technology2004，14，1： | 1 |
| 20 | An introduction to Biometric recognition显示文摘 | Jain A K Ross A Prabhakar S | 2004 | IEEE Trans on circuits and Systems for Video technology2004，14，1： | 1 |
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