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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Advances and applications of in- duced pluripotent stem cells 显示文摘 | Pietronave S Prat M | 2012 | Can J Physiol Pharmacol2012，90，： | 1 |
| 3 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 4 | Development of real-time PCR systems based on SYBR(R) Green I, Amplifluor (TM) and TaqMan (R) technologies for specific quantitative detection of the transgenie maize event GA21 显示文摘 | Hernandez M Esteve T Prat S | 2004 | J Cereal Sci2004，39，： | 1 |
| 5 | Development of real-time PCR systems based on SYBR~ Green I, Am- plifluorTM and TaqMan~ technologies for specific quantitative detection of the transgenic maize event GA21显示文摘 | Hern6ndez M Esteve T Prat S | 2004 | Journal of Cereal Science2004，39，1： | 1 |
| 6 | Prolonged persistence of Listeria monocytogenes after intragastric infection in corticosteroid - treated mice显示文摘 | PRATS N LOPEZ S DOMINGO M | | Vet Microbiol0，58，1： | 1 |
| 7 | Conserved MYC transcription factors play a key role in jasmonae signaling both in tomato and Arabidopsis显示文摘 | BOTER M RUIZ-RIVERO O ABDEEN A PRAT S | 2004 | Genes2004，18，： | 1 |
| 8 | Transforming shape in design: observations from studies of sketching 显示文摘 | PRATS M LIM S JOWERS I | 2009 | Design Studies2009，30，5： | 1 |
| 9 | A cDNA clone highly expressed in ripe banana fruit shows homology to pectate lyases显示文摘 | Dominguez-Puigianer E Llop I Vendrell M Prat S | 1997 | Plant Physiology1997，114，： | 1 |
| 10 | Naturally occurring allele diversity allows potato cultivation in northern latitudes 显示文摘 | Kloosterman B Abelenda J A Gomez Mdel M Oortwijn M de Boer J M Kowitwanich K Horvath B M van Eck H J Smaczniak C Prat S Visser R G Baehem C W | 2013 | Nature2013，495，7440： | 1 |
| 11 | Prolonged persistenee of listeria monoeytogengs after intragastrie infec- tion in cortieosteroidtreated mice 显示文摘 | Prats N LoPez S Domingo M | 1997 | Vet Microbiol1997，58，1： | 1 |
| 12 | Femtoscopy in Relativistic Heavy Ion Collisions显示文摘 | Lisa M Prat t S Soltz R | 2005 | Ann Rev Nucl Part Sci2005，55，： | 1 |
| 13 | Development of realtime PCR systems based on SYBR Green I,AmplifluorTM and TaqMan technologies for specific quantitative detection of the transgenic maize event GA21显示文摘 | HERNANDEZ M ESTEVE T PRAT S | 2004 | Journal of Cereal Science2004，39，1： | 1 |
| 14 | A molecular framework for light and gibberellin control of cell elongation显示文摘 | Lucas M D Daviere J M Rodriguez-Falc6n M Pontin M Lglesias-Pedraz J M Lorrain S Fankhauser C Blslzquez M A Titarenko E Prat S | | 0，，： | 1 |
| 15 | Surface and subsurface flow in eucalyptus plantations in north -central Portugal显示文摘 | Boulet A K Prats S A Malvar M C | 2015 | Jour- nal of Hydrology & Hydromechanics2015，63，3： | 1 |
| 16 | Nadir CA-125 concentrationin the normal range as an independent prognostic factor for opti-mally treated advanced epithelial ovarian cancer显示文摘 | Prat A Parera M Peralta S | 2008 | Ann On-col2008，19，： | 1 |
| 17 | Nadir CA-125 concentration in the normal range as an independent prognostic factor for optimally treated advanced epithelial ovarian caneer显示文摘 | Prat A Parera M Peralta S | 2008 | Ann Oncol2008，19，2： | 1 |
| 18 | Pore network simulation of evaporation of a binary liquid from a capillary porous medium显示文摘 | De Freitas D S Prat M | 2000 | Transport in Porous Media2000，40，1： | 1 |
| 19 | Development of real - time PCR systems based on SYBR Green I, amplifluor and TaqMan tech- nologies for specific quantitative detection of the transgenic maize e- vent GA21显示文摘 | Hernandez M Esteve T Prat S | 2004 | J Cereal Sci2004，39，： | 1 |
| 20 | Advances and applications of in- duced pluripotent stem cells 显示文摘 | Pietronave S Prat M | 2012 | Can J Physiol Pharma- col2012，90，： | 1 |
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