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| 1 | Artificial rearing influences the morphology,permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets显示文摘Background: In this study the physiological implications of artificial rearing were investigated. Low(LBW) and normal birth weight(NBW) piglets were compared as they might react differently to stressors caused by artificial rearing. In total, 42 pairs of LBW and NBW piglets from 16 litters suckled the sow until d19 of age or were artificially reared starting at d3 until d19 of age. Blood and tissue samples that were collected after euthanasia at 0, 3, 5, 8 and 19 d of age. Histology, ELISA, and Ussing chamber analysis were used to study proximal and distal small intestine histomorphology, proliferation, apoptosis, tight junction protein expression, and permeability. Furthermore, small intestine,liver and systemic redox parameters(GSH, GSSG, GSH-Px and MDA) were investigated using HPLC.Results: LBW and NBW artificially reared piglets weighed respectively 40 and 33% more than LBW and NBW sowreared piglets at d19(P < 0.01). Transferring piglets to a nursery at d3 resulted in villus atrophy, increased intestinal FD-4 and HRP permeability and elevated GSSG/GSH ratio in the distal small intestine at d5(P < 0.05). GSH concentrations in the proximal small intestine remained stable, while they decreased in the liver(P < 0.05). From d5 until d19, villus width and crypt depth increased, whereas PCNA, caspase-3, occludin and claudin-3 protein expressions were reduced. GSH,GSSG and permeability recovered in artificially reared piglets(P < 0.05).Conclusion: The results suggest that artificial rearing altered the morphology, permeability and redox state without compromising piglet performance. The observed effects were not depending on birth weight. | Hans Vergauwen Jeroen Degroote Sara Prims Wei Wang Erik Fransen Stefaan De Smet Christophe Casteleyn Steven Van Cruchten Joris Michiels Chris Van Ginneken | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 2 |
| 2 | Shortest connection networks and some generalizations 显示文摘 | Prim R C | 1997 | Bell System Technical Journal1997，36，： | 1 |
| 3 | Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31 (hi) Ly-6C (neg)bone marrow precursors in a mouse model of asthma显示文摘 | van Rijt IS Prims JB Leenen PJ | 2002 | Blood2002，1130，10： | 1 |
| 4 | Autoantibndy-mediated demyelination depends on complement activation but not activatroy Fc-re ceptors 显示文摘 | Urich E Guteher I Prim M | 2006 | Proc Natl Acad Sci U S A2006，103，18： | 1 |
| 5 | Hydredesulfurization of dibenzo- tliiophene and 4, 6-dimethyl-dibenzothiopheneover stdfided NiMo/r-Al 03 catalysts 显示文摘 | Marina Egorova Roel Prim | 2004 | Journal of Catalysis2004，225，： | 1 |
| 6 | Shortest connection networks and some generalizations 显示文摘 | PRIM R C | 1957 | Bell System Technical Journal1957，36，6： | 1 |
| 7 | Increased expression of the breast cancer resistance protein(BCRP) in relapsed or refractory acute myeloid leukemia(AML) 显示文摘 | Van den Heuvel-Eibrink MM Wiemer EA Prim A | 2002 | Leukemia2002，16，5： | 1 |
| 8 | Apolipoprotein E polymor- phism and stroke in a population from eastern Turkey 显示文摘 | Duzenli S Prim I Gepdiremen A | 2004 | J Neuro- genet2004，18，： | 1 |
| 9 | Effect of failed computed tomogTaphy-guided and endoscopic drainage on pancreatic pseudocyst management 显示文摘 | Rao R Fedorak I Prim RA | 1993 | Surgery1993，114，： | 1 |
| 10 | Shortest connection networks and generaliza- tion 显示文摘 | PRIM R C | 1957 | Bell System Tech1957，36，： | 1 |
| 11 | Shortest connection networks and some genera-tions 显示文摘 | Prim R C | 1957 | Bell System Technical Journal1957，36，6： | 1 |
| 12 | Silent brain infarcts and the risk of dementia and cognitive decline 显示文摘 | Vemeer S Prim ND den Heijer T | 2003 | N Engl J Med2003，348，： | 1 |
| 13 | Neurological complications following functional neck dissection显示文摘 | Prim MP De Diego JI Verdaguer JM | 2006 | Eur Arch Otorhinolaryngol2006，263，5： | 1 |
| 14 | Shortest Connection Networks and Some Generations显示文摘 | Prim R C | 1957 | Bell System Technical Journal1957，36，6： | 1 |
| 15 | Patency and flow of the internal jugular vein after functional neck dissection显示文摘 | Prim MP De Diego JI Fernández-Zubillaga A | 2000 | Laryngoscope2000，110，1： | 1 |
| 16 | Shortest connection networks and some generalizations显示文摘 | Prim R C | 1957 | Bell system technical journal1957，36，6： | 1 |
| 17 | Seasonal patterns of idiopathic facial paralysis A 16-year study显示文摘 | De Diego JI Prim MP Madero R | 1999 | Otolaryngol Head Neck Surg1999，120，： | 1 |
| 18 | Platelet count: association with prognosis in lung cancer显示文摘 | Gonzalez Barcala FJ Garcia Prim JM Moldes Rodriguez M | 2010 | Med Oncol2010，27，2： | 1 |
| 19 | Shortest connection networks and some generalization显示文摘 | PRIM R C | 1957 | B S T J1957，36，6： | 1 |
| 20 | Serum quit in levels in Patients with normal aicohalie stead hepatitis 显示文摘 | Sava's MC Karuk M Prim I etal | 2003 | Hepatic gastroenterology2003，50，51： | 1 |
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