|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Two Faces of One Seed: Hormonal Regulation of Dormancy and Germination显示文摘种子植物演变维持刚成熟的种子的休眠直到萌芽的适当时间。种子休眠和萌芽是不同生理的过程,并且到萌芽的从休眠的转变是在植物的生命周期的关键发展的步,但是为农业生产也是重要的不仅。这些过程被多样的内长的荷尔蒙和环境暗示精确调整。尽管骆驼毛的织物(abscisic 酸) 和气体(赤霉素) 被知道是反对地调整种子休眠的主要植物激素,最近的调查结果表明那另外一个植物激素,植物生长素,为导致并且维持也是批评的播种休眠,可能因此充当种子休眠的一个关键保护者。在这评论,我们总结我们在调整种子休眠和萌芽包含植物激素的关键角色的复杂分子的网络的当前的理解,在里面它 AP2-domain-containing 抄写因素 playkey 角色。我们也在种子休眠和萌芽讨论多样的神经质的信号的相互作用(串音) ,集中于组成中央节点的 ABA/GA 平衡。 | Kai Shu Xiao-dong Liu Qi Xie Zu-hua He | 2016 | Molecular Plant2016，9，1： | 95 |
| 2 | Performance value of high risk factors in colorectal cancer screening in China显示文摘AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in China.METHODS:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire investigation.Patients with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo colonoscopy.RESULTS:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced neoplasia.The iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and adenomas.The sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous polyps.Except for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra abnormality.CONCLUSION:The iFOBT may be the best marker for screening for advanced neoplasias and adenomas.Some unique high risk factors may play an important role in CRC screening in China. | Wen Meng Shan-Rong Cai Lun Zhou Qi Dong Shu Zheng Su-Zhan Zhang | 2009 | World Journal of Gastroenterology2009，15，48： | 41 |
| 3 | Reduction of the incidence and mortality of rectal cancer bypolypectomy:a prospective cohort study in Haining County显示文摘AIM: To reduce the incidence and morlality of rectal cancerand address the hypothesis that colorectal cancer often arisefrom precursor lesion (s), either adenomas or non-alenomatous polyps, by conducting a population-basedmass screening for colorectal cancer in Haining County,Zhejiang, PRCMETHODS: From 1977 to 1980, physicians screened thepopulation of Haining County using 15 cm rigid endoscopy.Of over 240 000 participants, 4076 of them were diagnoselwith Precursor Iesions, eitler alenomas or non-adenomatous polyps, which were then removedl surgically.All individuals with precursor lesionswere followed up andreexamined by endoscopy every two to five years upto 1998.RESULTS: After the initial screening, 953 metactronousadenomas and 417 non-adenomatous polyps ware detected andremoved from the members of this cohort. Further, 27 cases ofcolorectal cancer were detected and treated. Log-rank tuestsshowed that the survival time among those cancer patients whounderwent mass screening increased significantly comparedtothat of other colorectal cancer patients (P < 0.0001). Accordingto the population-based cancer registry in Haining County,age-adjusted incidence and mortality of rectal cancer decreasedby 41% and 29 % from 1977-1981 to 1992-1996, respectively.Observed cumulative 20-year rectal cancer incidence was 31%lower than the expected in the screened group; the mortalitydue to rectal cancer was 18 % lower thah the expected in thescreened group.CONCLUSION: Mass screening for rectal cancer andprecursor lesions with protocoscopy in the generalpopulation and periodical following-up with routineendoscopy for high-risk patients may decrease both theincidence and mortality of rectal cancer. | Shu Zheng Xi-Yong Liu Qi Dong,Cancer Institute,Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Ke-feng Ding Lin-Bo Wang Pei-Lin Qiu Su-Zhan Zhang,The 2~(nd)affiliated Hospital,Medical School of Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Xin-Feng Ding Yong-Zhou Shen Gao-Fei Shen Oi-Rong Sun Wei-Dong Li,Haining Cancer Institute,Haining 314400,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 37 |
| 4 | Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma显示文摘AIM: To clarify the association of vascular endothelial growth factor (VEGF) and microvascular density (MVD) expression with the angiogenesis and prognosis of colorectal cancer.METHODS: A total of 97 cases of colorectal cardnomas were examined by immunohistochemical staining (SP method), using anti-VEGF and anti-factor CD34^+ monodonal antibodies,RESULTS: VEGF positive staining was obtained in 68 out of 97 cases (70.1%), and observed mainly in the cytoplasm of tumor cells, and also frequently in stromal cells. VEGF expression was more intense in poorly differentiated adenocarcinoma in comparison with others, but there was no significant correlation between VEGF expression and age,sex and stage. A significant correlation was found between the MVD and grades, and there was no significant relationship between the MVD and age, sex, and stage. The MVD in the VEGF positive group (68 cases) was higher than that in the negative group. Upon multivariate analysis, the significant variables were stage, tumor grade and MVD; VEGF expression was not an independent prognostic factor.CONCLUSION: The expression of VEGF has a significant correlation with MVD; MVD expression has prognostic value but VEGF has not in colon cancer. | Shu Zheng Ming-Yong Han Zuo-Xiang Xiao Jia-Ping Peng Qi Dong Cancer Institute,Zhejiang University,Hangzhou 310009,Zhejiang Province,China | 2003 | World Journal of Gastroenterology2003，9，6： | 38 |
| 5 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 6 | Magnetic resonance susceptibility weighted imaging in detecting intracranial calcification and hemorrhage显示文摘背景计算断层摄影术(CT ) 在检测 intracranial 石灰化比平淡的磁性的回声成像(MRI ) 好。试图估计在 intracranial 石灰化和 hemorrhage.Methods 的察觉和区别的加权的成像(SWI ) 在这研究注册了的先生危险性的价值的这研究是包括 CT 表明的石灰化的 13 个盒子和 intracerebral 出血的 22 个盒子的 35 个病人。在所有这些题目使用的先生序列包括了轴的 T1WI, T2WI 和 SWI。SWI 上的石灰化和出血的阶段移动(PS ) 被计算,他们的信号在改正的阶段图象上展示被比较。在检测 intracranial 石灰化和出血的 T1WI, T2WI 和 SWI 的敏感是为头部的石灰化的 SWI 的察觉率是的分析 statistically.Results 98.2% ,比 T1 Wl 和 T2WI 的显著地高。它不与 CT 的显著地不同(P > 0.05 ) 。在不同阶段有 49 出血性的损害检测 n SWI, 30 在 T2WI 上并且 18 在 T1WI 上。石灰化和出血的平均 PS 是在检测的 +0.734han 常规 MRI 微出血, SWI 可以在区分与石灰化或出血联系的服的疾病起一个重要作用。 | ZHU Wen-zhen QI Jian-pin ZHAN Chuan-jia SHU Hong-ge ZHANG Lin WANG Cheng-yuan XIA Li-ming HU Jun-wu FENG Ding-yi | 2008 | Chinese Medical Journal2008，，20： | 26 |
| 7 | Twenty-five years of change in scleractinian coral communities of Daya Bay (northern South China Sea) and its response to the 2008 AD extreme cold climate event显示文摘世界范围的珊瑚礁石逐渐地正在变得并且有害地影响在之上由包括的许多因素,重要气候变化,例如全球温暖和增加的 El Nino 南部的摆动活动。通常,珊瑚礁石的坚持,在特别低纬度,部分地,海运被管理不超过集体死亡能在发生的批评限制(∼30 ° C ) 的表面温度。因此,它被想珊瑚那生活在高纬度(即,当前更凉爽的海表面温度) 将多半比珊瑚生活在对假设未来温度增加更有利作出回应低纬度(即,当前更温暖的海表面温度) 。因而,高纬度的珊瑚社区可以有潜力在面临潜在的未来时为许多珊瑚种类充当 refugia 的区域全球温暖。Daya 海湾(22 ° 3 1 ′22 ° 5 0 ′N ) ,北华南海,包含几个高纬度的 non-reefal 珊瑚社区并且在这个区域以内代表 scleractinian 珊瑚的最在北方的分布之一。显著地, Daya 海湾经历了在整个过去的 50 年的在空和海表面温度中的戏剧的温暖。在这篇论文,我们在 Daya 海湾珊瑚社区分析 25 年变化,把两个基于历史性的调查并且我们的最近 2006 2008 地区性的生态的调查。我们的结果建议与预言相反,在过去的 25 年期间在在 Daya 海湾以内的珊瑚盖子有重要衰落(即,在到在 2008 的 15.3% 仅仅珊瑚盖子的 1983/1984 的 76.6% 珊瑚盖子) 。如此的变化也在最丰富的珊瑚种类反映重要移动,从 Acropora pruinosa 到 Favites abdita。大多数现代珊瑚社区变得以前在 15 和 30 年之间建立了,相应于增加的冬季海表面温度的一个时期。然而,很少的殖民地变得在最后 15 年以内建立了,尽管有温暖的一个更强烈的时期。由考虑另外的因素,我们假设那直接人为的影响,而非气候的事件,限制了发展,并且驾驶了衰落,最后 15 年里的 Daya 海湾珊瑚社区。Daya 海湾也在过去的 50 年期间受到了偶尔的极端冷事件,与最近的发生在 2008 年初(13 年 1 月 13 日 2 月) 。在 2008 冷事件期间,最低空气温度到达仅仅 6.6 ° C,和吝啬的海表面温度 2 月秋天,包括在 12.3 ° C 的六连续的天 < 14 ° C。显著地,海表面温度在通常在 scleractinian 珊瑚社区导致集体死亡的假设批评更低的温度阀值(∼13 ° C ) 下面掉落。令人惊讶地,我们的珊瑚社区调查,以前进行了两个(2007 年 8 月) 并且在以后(2008 年 2 月下旬) 极端 2008 冷事件,证明 Daya 海湾珊瑚生态系统恰好被影响在之上在冷时期期间。那些观察建议 Daya 海湾 scleractinian 珊瑚社区开发了改编到低海表面温度。总的来说,我们的数据支持高纬度的珊瑚社区例如 Daya 海湾,有的假设在潜在的未来的来临为 scleractinian 珊瑚充当 refugia 的区域的潜力全球温暖。 | CHEN TianRan YU KeFu SHI Qi LI Shu Gilbert J. Price WANG Rong ZHAO MeiXia CHEN TeGu ZHAO JianXin | 2009 | Chinese Science Bulletin2009，54，12： | 22 |
| 8 | Pneumoconiosis: current status and future prospects显示文摘Pneumoconiosis refers to a spectrum of pulmonary diseases caused by inhalation of mineral dust,usually as the result of certain occupations.The main pathological features include chronic pulmonary inflammation and progressive pulmonary fibrosis,which can eventually lead to death caused by respiratory and/or heart failure.Pneumoconiosis is widespread globally,seriously threatening global public health.Its high incidence and mortality lie in improper occupational protection,and in the lack of early diagnostic methods and effective treatments.This article reviews the epidemiology,safeguard procedures,diagnosis,and treatment of pneumoconiosis,and summarizes recent research advances and future research prospects. | Xian-Mei Qi Ya Luo Mei-Yue Song Ying Liu Ting Shu Ying Liu Jun-Ling Pang Jing Wang Chen Wang | 2021 | Chinese Medical Journal2021，，8： | 22 |
| 9 | TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-1inked ubiquitination显示文摘RIG-I 是认出病毒的 RNA 的不同种类的一个枢轴的细胞质的传感器。这识别导致抄写因素 NF-B 和 IRF3,它协作导致打的 activationof 我干扰素(IFN ) 和天生的抗病毒的 response.In 这研究,我们作为 RIG-I-mediated IFN 的一个积极管理者识别了整齐的家庭蛋白质 TRIM4 感应。Overexpressionof TRIM4 加强了 IRF3 和 NF-B 的被触发病毒的激活,以及 IFN- 正式就职,而 TRIM4had 相反的效果击倒。机械学地, TRIM4 与 RIG-I 联系并且为连接 K63 的 polyubiquitination 指向它。我们 TRIM4 是由调停的导致病毒的 IFN 正式就职小径的一个重要管理者的 findingsdemonstrate 为 K63-linkedubiquitination 的 RIG-I。 | Jie Yan Qi Li Ai-Ping Mao Hong-Bing Shu | 2014 | Journal of Molecular Cell Biology2014，8，2： | 21 |
| 10 | Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway显示文摘Objective: To investigate the effects of ursolic acid on the proliferation and apoptosis of human HT-29 colon cancer cells. Methods: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays were performed to evaluate the effects of ursolic acid on the growth and apoptosis of HT-29 cells. Western blot analysis was applied to investigate the inhibitory effects of ursolic acid on the phosphorylation of the epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), and the activity of B cell leukemia-2 (Bcl-2), B cell leukemia-xL (Bcl-xL), caspase-3, and caspase-9. Results: Ursolic acid inhibited the growth of HT-29 cells in dose- and time-dependent manners. The median inhibition concentration (IC50) values for 24, 48, and 72 h treatment were 26, 20, and 18 μmol/L, respectively. The apoptotic rates of 10, 20, and 40 μmol/L ursolic acid treatments for 24 h were 5.74%, 14.49%, and 33.05%, and for 48 h were 9%, 21.39%, and 40.49%, respectively. Ursolic acid suppressed the phosphorylation of EGFR, ERK1/2, p38 MAPK, and JNK, which is well correlated with its growth inhibitory effect. 10, 20, and 40 μmol/L ursolic acid significantly inhibited the proliferation of EGF-stimulated HT-29 cells (P<0.05). Cell proliferation was most significantly inhibited when treated with 10 and 20 μmol/L ursolic acid combined with 200 nmol/L AG 1478 or 10 μmol/L U0126 (P<0.01). Besides, it also down-regulated the expression of Bcl-2 and Bcl-xL and activated caspase-3 and caspase-9. Conclusion: Ursolic acid induces apoptosis in HT-29 cells by suppressing the EGFR/MAPK pathway, suggesting that it may be a potent agent for the treatment of colorectal cancer. | Jian-zhen SHAN Yan-yan XUAN Shu ZHENG Qi DONG Su-zhan ZHANG | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，9： | 19 |
| 11 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 12 | Nickel accumulation and its effects on the survival rate of Spodoptera litura Fabricius under continuous nickel stress显示文摘The artificial diets mixed with various concentrations of nickel were offered to the larvae of the phytophagous insect Spodoptera litura Fabricius for 3 generations. Nickel accumulations in the 6th instar larvae, pupae and newly emerged adults of the corresponding generations of S. litura were investigated by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES), and the effects of nickel accumulations on the survival rate of S. litura were also evaluated by individual rearing. The results showed that nickel accumulated in the 6th instar larvae, pupae and adults of S. litura, and the accu- mulated nickel in all the tested developmental stages within a generation increased with the increase of the nickel doses in the treated diets and showed significant dose-dependent relationship with the nickel doses in the artificial diets. The results also indicated that the nickel accumulations in the 6th instar larvae, pupae, and newly emerged adults from the 3rd generation were higher than those from the 2nd generation, which were also higher than those from the 1st generation. Nickel concentrations in pupae and adults were significantly lower than those in larvae, which indicated that the excessive nickel might be excreted during metamorphosis. Furthermore, larval survival rate, pupation rate and eclosion rate of S. litura in the tested three generations all decreased with the increase of the nickel doses in the treated diets. | SUN HongXia SHU YingHua TANG WenCheng WANG Qi ZHOU Qiang ZHANG GuRen | 2007 | Chinese Science Bulletin2007，52，14： | 16 |
| 13 | Assessment of coral bleaching using symbiotic zooxanthellae density and satellite remote sensing data in the Nansha Islands,South China Sea显示文摘Coral bleaching,characterized by a significant loss of symbiotic zooxanthellae,is the primary cause of mass coral mortality and reef degradation throughout the world.The characteristics,processes,and resistance of corals to bleaching varies significantly and is dependent on environmental conditions.We documented a mass coral bleaching event in June 2007 at the Meiji and Zhubi Reefs,Nansha Islands (NS),South China Sea using ecological surveys and measurement of coral zooxanthellae density and sea surface temperatures (SST).More than 35 species of corals (between 0-20 m in depth) were bleached.These bleached corals accounted for 15.6% of total corals in the investigated quadrats.The branching corals Pocillopora and Acropora were the most vulnerable species whereas the massive corals Porites and Favia were more tolerant of the high SSTs.Surprisingly,we found no evidence of bleaching in Agariciidae corals suggesting that this family is resistant to thermal stresses.The bleached corals had lost 72%-90% of their symbiotic zooxanthellae.Furthermore,corals that had no visual signs of bleaching had also lost 31%-53% of their zooxanthellae suggesting that most corals were experiencing the early stage of bleaching.The monthly mean SST during June 2007 was 30.8°C,the highest since 1998.Based on measurements of SST and the Hotspots and DHW data (NOAA),we conclude that it the extremely high SSTs triggered this coral bleaching event.Our results suggest that the previously accepted temperature thresholds used to predict coral bleaching based on satellite data are likely to underestimate the extent and intensity of coral bleaching,at least in the NS. | LI Shu,YU KeFu,CHEN TianRan,SHI Qi & ZHANG HuiLing CAS Key Laboratory of Marginal Sea Geology,South China Sea Institute of Oceanology,Chinese Academy of Sciences Guangzhou 510301,China | 2011 | Chinese Science Bulletin2011，56，10： | 15 |
| 14 | The distribution characteristics of heavy metals in Guiyang urban soils显示文摘Guiyang is located in southwestern China,which is a famous tourism city,and is awarded the title of'the Summer Capital of China'.A study on heavy metals in Guiyang urban soils was conducted.The results showed that the concentrations of Cd,Cu,Ni,Pb and Zn in Guiyang urban soils are significantly higher than their background values and Cu,Zn and Pb in Guiyang soils are accumulated seriously.The distribution characteristics of heavy metals in 3 districts are described as follows:the level of heavy metals in soils follows the order of Nanming District> Yunyan District>Xiaohe District.The spatial distribution of metals in urban soils of Guiyang shows that the level of metals in the central and eastern parts of Guiyang is relatively high,and its characteristics are attributed to the influence of commercial activities,heavy traffic and industrial emission.Compared with some other cities in China,Guiyang is characterized by relatively high accumulation level of Cd,Cu,and Zn in its soils. | LI Xiaoyan CAO Yijin QI Le SHU Fu | 2012 | Chinese Journal Of Geochemistry2012，31，2： | 14 |
| 15 | PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum显示文摘在充满脯氨酸的 transmembrane 蛋白质的变化(PRRT2 ) 2 与发作性的 kinesigenic 运动障碍(PKD ) 和几另外的发作性的神经病学的疾病被联系,但是 PRRT2 功能和病原的机制仍然保持大部分阴暗。这里,我们证明 PRRT2 是与 SNARE 建筑群和 downregulates 的部件交往的 presynaptic 蛋白质它的形成。Loss-of-function 变异的老鼠显示出显型由小脑的概括发作,过高热,或 optogenetic 刺激触发了的象 PKD 一样。有在小脑的小粒房间(GC ) 的特定的 PRRT2 删除的变异的老鼠概括在 Prrt2 空的老鼠看见的行为的显型。而且,记录在显示出的小脑的片做了在短暂举起的 GC 结果的刺激由 Purkinje 房间开火的抑制跟随了的那 optogenetic。在 PKD 处理使用的 anticonvulsant 药 carbamazepine 也在变异的老鼠减轻了象 PKD 一样行为。一起,我们的调查结果作为 SNARE 建筑群的一个新奇管理者识别 PRRT2 并且提供位于 PRRT2 相关的行为下面的电路机制。 | Guo-He Tan Yuan-Yuan Liu Lu Wang Kui Li Ze-Qiang Zhang Hong-Fu Li Zhong-Fei Yang Yang Li Dan Li Ming-Yue Wu Chun-Lei Yu Juan-Juan Long Ren-Chao Chen Li-Xi Li Lu-Ping Yin Ji-Wei Liu Xue-Wen Cheng Qi Shen You-Sheng Shu Kenji Sakimura Lu-Jian Liao Zhi-Ying Wu Zhi-Qi Xiong | 2018 | Cell Research2018，28，1： | 14 |
| 16 | A voltage resonance-based single-ended online fault location algorithm for DC distribution networks显示文摘A novel single-ended online fault location algorithm is investigated for DC distribution networks. The proposed algorithm calculates the fault distance based on the characteristics of the voltage resonance. The Prony's method is introduced to extract the characteristics. A novel method is proposed to solve the pseudo dual-root problem in the calculation process. The multiple data windows are adopted to enhance the robustness of the proposed algorithm. An index is proposed to evaluate the accuracy and validity of the results derived from the various data windows. The performances of the proposed algorithm in different fault scenarios were evaluated using the PSCAD/EMTDC simulations. The results show that the algorithm can locate the faults with transient resistance using the 1.6 ms data of the DC-side voltage after a fault inception and offers a good precision. | JIA Ke LI Meng BI Tian Shu YANG Qi Xun | 2016 | Science China(Technological Sciences)2016，59，5： | 13 |
| 17 | New Triterpenes from Siyekucai (Ixeris chinensis)显示文摘Three new triterpenes, 3β,21α-dihydroxylupen-18(19)-en (1), 3β,25-dihydroxytirucalla-7,23(24)-dien (2), and 21α-hydroxy-19α-hydrogentaraxasterol-20(30)-en (3) were obtained froman ethyl acetate extract of the whole plant of Siyekucai (Ixeris chinensis). The structures of 1-3were determined by spectroscopic methods (EIMS, IR, 1D and 2D NMR). | Shu Jun ZHANG Jin Lan WANG Qi Gang DENG Masayoshi ANDO | 2006 | Chinese Chemical Letters2006，17，2： | 13 |
| 18 | Interspecies and spatial diversity in the symbiotic zooxanthellae density in corals from northern South China Sea and its relationship to coral reef bleaching显示文摘珊瑚礁石漂白被共生 zooxanthellae, zooxanthellae 色素沉着的损失,或两个的逐出通常描绘。我们收集了分别地,在海南岛的 Sanya 和广东省的 Daya 海湾从 Luhuitou 和 Xiaodonghai 包括礁石大楼珊瑚的 21 个类的 39 种类的 128 件样品并且分析了共生 zooxanthellae 人口密度。结果显示出那:( 1 )共生 zooxanthella 密度从 0.67x10 ( 6 )变化,显示 8.48x10 ( 6 )房间/厘米( 2 )重要内部种可变性,与通常相对有更少的 zooxanthellae 的分支珊瑚(从 0.67x10 ( 6 ) 到 2.47x10 ( 6 )房间/厘米( 2 ))比巨大的种类(从 1.0x10 ( 6 )到 8.48x10 ( 6 )房间/厘米( 2 ));(2 ) 在 4 m 水深度以内住在的珊瑚比那些生活在底部有共生 zooxanthellae 的高水平(类似于 7 m 深度) 礁石区域;(3 ) 在在从相对高的纬度 Daya 海湾的珊瑚之间的 zooxanthellae 密度没有可辨别的差别(类似于 22 度 N ) 并且那些从相对低的纬度 Sanya (类似于 18 度 N ) 在可比较的海表面温度(SST ) ;(4 ) 在里面部分 -- 漂白珊瑚, zooxanthellae 的密度显示出下列顺序:看似健康的部分 > 漂白半的部分 > 漂白部分。基于上述结果,我们建议(1 ) 分叉之间的 zooxanthellae 密度差别和巨大的珊瑚种类是分叉的珊瑚对比巨大的珊瑚漂白更脆弱的主要原因。例如,共生 zooxanthellae 层次在分叉的 Acropora 和 Pocillopora 珊瑚并且这样是低的这些珊瑚更产生漂白和死亡;(2 ) 共生 zooxanthellae 密度能被环境条件也影响,例如沉积负担,潜水相关的混浊,和水产业相关的硝酸盐和磷酸盐输入,并且他们的增加可以在珊瑚减少共生 zooxanthellae 密度。 | LI Shu YU KeFu SHI Qi CHEN TianRan ZHAO MeiXia ZHAO JianXin | 2008 | Chinese Science Bulletin2008，53，2： | 12 |
| 19 | Four new constituents from Taraxacum mongolicum显示文摘二新黄酮 glycosides ,isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- l-arabinopyranoside ( 1 )和isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- d-glucopyranoside ( 2 ),新 lignan , mongolicumin A ( 3 ),和新 guaianolide , mongolicumin B ( 4 )从薄公英属 mongolicum 的天线部分被孤立。他们的结构被主要阐明光谱分析。 | Shu Yun Shi Qi Zhou Hua Peng Chang Xin Zhou Ming Hui Hu Qiao Feng Tao Xiao Jiang Hao Joachim Stoeckigt Yu Zhao | 2007 | Chinese Chemical Letters2007，18，11： | 11 |
| 20 | Construction of HBV-specific ribozyme and its recombinant with HDV and their cleavage activity in vitro显示文摘AIM To construct the recombinant of HDVcDNA and HBV-specific ribozyme gene byrecombinant PCR in order to use HDV as atransporting vector carrying HBV-specificribozyme into liver cells for inhibiting thereplication of HBV.METHODS We separately cloned the ribozyme(RZ)gene and recombinant DVRZ(comprisingHDV cDNA and HBV-specific ribozyme gene)intothe downstream of T7 promoter of pTAdv-Tvector and studied the in vitro cleavage activityof their transcripts(rRZ,rDVRZ)on target RNA(rBVCF)from in vitro transcription of HBV Cgene fragment(BVCF).RESULTS Both the simple(rRZ)and therecombinant ribozyme rDVRZ could efficientlycatalyze the cleavage of target RNA(rBVCF)under different temperatures(37℃,42℃ and55℃)and Mg2+concentrations(10 mmol/L,15 mmol/L and 20 mmol/L)and their catalyticactivity tended to increase as the temperaturewas rising.But the activity of rRZ was evidentlyhigher than that of rDVRZ.CONCLUSION The recombinant of HDV cDNAand ribozyme gene had the potential of beingfurther explored and used in gene therapy of HBVinfection. | Shu Juan Wen Kai Jun Xiang Zhen Hua Huang Rong Zhou Xue Zhong Qi | 2000 | World Journal of Gastroenterology2000，6，3： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员