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| 1 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 2 | A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia显示文摘Aim:In light of the antinociceptive activity of the short-chain neurotoxin,cobrotoxin,and other acetylcholine antagonists,the antinociceptive activity andmechanisms of cobratoxin(CTX),a long-chain postsynaptic α-neurotoxin,wasinvestigated in rodent pain models.Methods:CTX was administered intraperito-neally(30,45,68 μg/kg),intra-cerebral ventricularly(4.5 μg/kg)or microinjectedinto periaqueductal gray(PAG;4.5 μg/kg).The antinociceptive action was testedusing the hot-plate and acetic acid writhing tests m mice and rats.The involve-ment of the cholinergic system and opioid system in CTX-induced analgesia wasexamined by pretreatment of animals with atropine(0.5 mg/kg,im;or 10 mg/kg,ip)or naloxone(1 and 5 mg/kg,ip).The effect of CTX on motor activity was testedusing the Animex test.Results:CTX exhibited a dose-dependent analgesic ac-tion in mice as determined by both the hot-plate and acetic acid writhing tests.The peak effect of analgesia was seen 3 h after administration.In the mouse aceticacid writhing test,the intra-cerebral ventricular administration of CTX at 4.5 μg/kg(1/12th of a systemic dose)produced marked analgesic effects.Microinjection ofCTX(4.5 μgkg)into the PAG region did not elicit an analgesic action in rats in thehot-plate test.Atropine at 0.5 mg/kg(im)and naloxone at 1 and 5 mg/kg(ip)bothfailed to block the analgesic effects of CTX,but atropine at 10 mg/kg(ip)didantagonize the analgesia mediated by CTX in the mouse acetic acid writhing test.Acetylsalicylic acid(300 mg/kg)did not enhance the analgesic effects of CTX.Atthe highest effective dose of 68 μg/kg the neurotoxin did not change the sponta-neous mobility of mice.Conclusion:CTX has analgesic effects,which are medi-ated in the central nervous system though not through the PAG.The centralcholinergic system but not opioid system appears to be involved in theantinociceptive action of CTX. | Zhi-xin CHEN Hui-ling ZHANG Zhen-lun GU Bo-wen CHEN Rong HAN Paul F REID Laurence N RAYMOND Zheng-hong QIN | 2006 | Acta Pharmacologica Sinica2006，27，4： | 7 |
| 3 | Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin显示文摘 | Yan-li LIU Hai-ming LIN Rong ZOU Jun-chao WU Rong HAN Laurence N RAYMOND Paul F REID Zheng-hong QIN | 2009 | Acta Pharmacologica Sinica2009，30，2： | 6 |
| 4 | Involvement of cholinergic system in suppression ot formalin-induced inflammatory pain by cobratoxin显示文摘瞄准: 调查 cobratoxin (CTX ) 的止痛效果,长链的 α从泰国眼镜蛇恶意的神经毒素,在导致福尔马林的煽动性的疼痛的一个老鼠模型。 | Gao-na SHI Yan-li LIU Hai-ming LIN Shi-lin YANG Yu-lin Feng Paul F REID Zheng-hong QIN | 2011 | Acta Pharmacologica Sinica2011，32，10： | 6 |
| 5 | 东方蜜蜂高效的卫生行为机制对于西方蜜蜂抗病育种的启示显示文摘西方蜜蜂(Apismellifera)在世界各地大范围的蜂群损失现象已引起科学界和公众的广泛关注,其健康状况与东方蜜蜂(Apis cerana)相比明显较劣。东方蜜蜂群内可检测到的病原体和寄生虫相对较少,即它们对于生物威胁具有更强的抵抗力,即便是面对异种入侵的新病原(如蜜蜂残翅病毒)。 | Lin Z Page P Li L Qin Y Zhang Y Hu F Neumann P Zheng H Dietemann V 蔺哲广 郑火青 胡福良 | 2016 | 中国蜂业2016，67，12： | 5 |
| 6 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 7 | A Power and Area Optimization Approach of Mixed Polarity Reed-Muller Expression for Incompletely Specified Boolean Functions显示文摘力量和芦苇思考(RM ) 电路的区域优化广泛地被担心了。然而,几乎没有退出的力量和区域,优化来临能获得所有 Pareto 原版的最佳的答案问题并且足够有效。而且,他们没认为 dont 是照顾术语,它使电路成为性能不能进一步优化。在这糊,我们建议混合极性 RM 的一条力量和区域优化途径为不完全地指定的布尔功能的表示(MPRM ) 基于非统治的排序基因算法 II (NSGA-II ) 。第一,不完全地指定的布尔功能不完全地被转变成零极性由使用的指定 MPRM (ISMPRM ) 一篇小说 ISMPRM 获得算法。第二,极性和分配 ISMPRM 的照顾术语没作为染色体被编码。最后, Pareto 最佳的答案被使用 NSGA-II 获得,在里面哪个 MPRM 相应于给定的染色体被使用一个染色体获得变换算法。结果上重要力量和区域改进能与存在力量和区域优化相比被做的电路表演 RM 接近的不完全地指定的布尔功能和 MCNC 基准电路。 | Zhen-Xue He Li-Min Xiao Li Ruan Fei Gu Zhi-Sheng Huo Guang-Jun Qin Ming-Fa Zhu F Long-Bing Zhang Rui Liu Xiang Wang | 2017 | Journal of Computer Science & Technology2017，32，2： | 4 |
| 8 | Predicting hepatitis B viruspositive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning显示文摘 | Ye QH Qin LX F orgues M | 2003 | Nat Med2003，9，4： | 3 |
| 9 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 10 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 11 | Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10显示文摘 | Qin Z Salazar-Onfray F Charo J | 1997 | J Immunol1997，159，7： | 1 |
| 12 | Preparation of mesoporous carbon from commercial activated carbon with steam activation in the presence of cerium oxide显示文摘 | Shen W Z Zheng J T Qin Z F | 2003 | Journal of Colloid and Interface Science2003，264，2： | 1 |
| 13 | The electrochemical reaction of zinc oxide thin films with Lithium 显示文摘 | Huang F Qin Q Z | 2003 | J Electrochem Soc2003，150，6： | 1 |
| 14 | Haemolytic activity and adjuvant effect of Notoginsenoside K from the roots of Panax notoginseng显示文摘 | Sun HX Ye YP | 2006 | Chemistry & Biodiversity2006，3，10： | 1 |
| 15 | Involvenment of calcitonin gene-related peptide the depressor effects of losartan and period in rats显示文摘 | Qin xP Ye F Liao DF | 2003 | Eur J Pharmao12003，464，1： | 1 |
| 16 | An ionic liquid coating for determination of sildenafil and UK-103,320 in human serum by capillary zone electrophoresis-ion trap mass spectrometry显示文摘 | Qin Weidong Li Sam F Y | 2002 | Electrophoresis2002，23，24： | 1 |
| 17 | Involvement of calcitonin gene-related peptide in the depressor effects of losartan and perindopril in rats显示文摘 | Qin XP Ye F Liao DF | 2003 | Eur J Pharmacol2003，464，1： | 1 |
| 18 | Vibration characteristics of rotating thin cylindrical shells for various boundary conditions显示文摘 | Liu Y Q Qin Z Y Chu F L | 2012 | J Tsinghua Univ (Sci & Tech)2012，52，1： | 1 |
| 19 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 20 | Facile microwave synthesis of 3D flowerlike BiOBr nanostruetures and their excellent CrVI removal capacity显示文摘 | Li G F Qin F Yang H | 2012 | Eur J Inorg Chem2012，15，： | 1 |
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