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| 1 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 2 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 3 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 4 | Development and characterization of monoclonal antibody specific to nuclear protein of avian influenza virus type A 显示文摘 | LI N QIN A J SHAO H X | 2008 | Agricuhural Science & Technology2008，9，1： | 1 |
| 5 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 6 | Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in rechrrent febrile seizuresinrats显示文摘 | Han Y Qin J Chang X | 2005 | Neurosci Res2005，53，： | 1 |
| 7 | Structure and properties of novel electrospun tussah silk fibroin/poly (lactic acid) composite nano- fibers 显示文摘 | He J X Qin Y R Cui S Z | 2011 | J Mater Sei2011，46，9： | 1 |
| 8 | Transcriptional profile of Marek's disease virus genes in chicken thymus during different phases of MDV infection显示文摘 | Hu X Qin A Miao J | 2013 | Arch Virol2013，，： | 1 |
| 9 | Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032显示文摘 | Gioia J Yerrapragada S Qin X | 2007 | PLoS One2007，2，9： | 1 |
| 10 | Fabrication of Nd : YAG transparent ceramics with both TEOS and MgO additives 显示文摘 | Yang H Qin X P Zhang J | 2011 | J Alloys Compd2011，509，17： | 1 |
| 11 | Study of the synthesis and C12 gas-sensing properties of nanometer HNO3 -doped SnO2显示文摘 | Wang X B Qin N Lou T J | | 0，，： | 1 |
| 12 | An Iterative Method of Solution for Equilibrium and Optimization Problems显示文摘 | SU Y F SHANG M J QIN X L | 2008 | Nonlinear Anal2008，64，： | 1 |
| 13 | The prevalence of parasites and pathogens in Asian honeybees Apis cerana in China显示文摘 | Li J L Qin H R Wu J Sadd B M Wang X Evans J D Peng W Chen Y | 2012 | PLoS One2012，7，47： | 1 |
| 14 | Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial 显示文摘 | Huo Y Li J Qin X | 2015 | JAMA2015，313，13： | 1 |
| 15 | An extended VIKORmethod based on prospect theory for multiple attribute de-cision making under interval type-2 fuzzy environment显示文摘 | QIN J D UU X W PEDRYCZ W | 2015 | Knowledge-Based Systems2015，86，： | 1 |
| 16 | Influence of Green Spaces on Environmental Satisfaction and Physiological Status of Urban Residents显示文摘 | Qin J Zhou X Sun C | 2013 | Urban Forestry&Urban Greening2013，12，4： | 1 |
| 17 | GPU rendering for tiled multi-projector autostereoscopic display based on chro-mium 显示文摘 | Luo J L~ Qin K H Zhou Y X | 2010 | The Visual Computer (S0178-2789)2010，26，68： | 1 |
| 18 | Identification and mapping of amplified fragment length polymorphism markers linked to shell color in bay scallop, Argopecten irradians irradians (Lamarck, 1819) 显示文摘 | Qin Y J Liu X Zhang H B | 2007 | Marine Bioteehnology2007，9，1： | 1 |
| 19 | Outcome of patients with hypertrophic obstructive cardiomyopathy after percutaneous transluminal septal myocardial ablation and septal myectomy surgery显示文摘 | QIN J X SHIOTA T LEVER H M | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 20 | Extensible collagen in mussel byssus: a natural block copolymer显示文摘 | COYNE K J QIN X X WAITE J H | 1997 | Science1997，277，： | 1 |
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