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| 1 | Gut microbiota,inflammatory bowel disease and colorectal cancer显示文摘The gut microbiota is a complex community of microorganisms that inhabit the digestive tracts of humans,living in symbiosis with the host.Dysbiosis,characterized by an imbalance between the beneficial and opportunistic gut microbiota,is associated with several gastrointestinal disorders,such as irritable bowel syndrome(IBS);inflammatory bowel disease(IBD),represented by ulcerative colitis and Crohn’s disease;and colorectal cancer(CRC).Dysbiosis can disrupt the mucosal barrier,resulting in perpetuation of inflammation and carcinogenesis.The increase in some specific groups of harmful bacteria,such as Escherichia coli(E.coli)and enterotoxigenic Bacteroides fragilis(ETBF),has been associated with chronic tissue inflammation and the release of pro-inflammatory and carcinogenic mediators,increasing the chance of developing CRC,following the inflammationdysplasia-cancer sequence in IBD patients.Therefore,the aim of the present review was to analyze the correlation between changes in the gut microbiota and the development and maintenance of IBD,CRC,and IBD-associated CRC.Patients with IBD and CRC have shown reduced bacterial diversity and abundance compared to healthy individuals,with enrichment of Firmicute sand Bacteroidetes.Specific bacteria are also associated with the onset and progression of CRC,such as Fusobacterium nucleatum,E.coli,Enterococcus faecalis,Streptococcus gallolyticus,and ETBF.Future research can evaluate the advantages of modulating the gut microbiota as preventive measures in CRC high-risk patients,directly affecting the prognosis of the disease and the quality of life of patients. | Ana Elisa Valencise Quaglio Thais Gagno Grillo Ellen Cristina Souza De Oliveira Luiz Claudio Di Stasi Ligia Yukie Sassaki | 2022 | World Journal of Gastroenterology2022，28，30： | 7 |
| 2 | Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.)standardized CO2 phytopharmaceutical preparation显示文摘AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitrobenzenesulphonic acid(TNBS)model of rat intestinal inflammation.METHODS The animals were divided into groups that received vehicle or P.angulata extract(PACO_2)orally at the doses 25,50 and 100 mg/kg daily by 5 d before TNBS damage.Protective effects of PACO_2 were assessed by macroscopic analysis,biochemical determinations of the levels of myeloperoxidase(MPO),alkaline phosphatase(ALP),glutathione and cytokines(such as INF-γ,IL-1β,IL-6,IL-10 and TNF-α),gene expression evaluation(including Hsp70,heparanase,NF-κB,mitogenactivated protein kinases(Mapk)1,3,6 and 9,and the mucins genes Muc 1,2,3 and 4)and histopathological studies using optical,and electronic(transmission and scanning)microscopy.RESULTS PACO2 extract promoted a significant reduction in MPO and ALP activities,reducing oxidative stress and neutrophil infiltration.These effects were accompanied by significant reduction of colonic levels of IFN-γand IL-6 and down-regulation of heparanase,Hsp70,Mapk3,Mapk9,Muc1 and Muc2 genes expression when compared with TNBS-control animals.In addition,protective effects were also evidenced by reduced neutrophil infiltration,recovery of cell architecture and replacement of mucin by histopathological and ultrastructural analysis.CONCLUSION Physalis angulata supercritical CO2 extract is an intestinal anti-inflammatory product that modulates oxidative stress,immune response and expression of inflammatory mediators,with potentially utility for treating inflammatory bowel disease. | luiz domingues almeida junior ana elisa valencise quaglio celso acácio rodrigues de almeida costa Luiz Claudio Di Stasi | 2017 | World Journal of Gastroenterology2017，23，24： | 4 |
| 3 | MicroRNAs expression influence in ulcerative colitis and Crohn's disease:A pilot study for the identification of diagnostic biomarkers显示文摘BACKGROUND Inflammatory bowel disease(IBD)comprises two distinct diseases,Crohn’s disease(CD)and ulcerative colitis(UC),both of which are chronic,relapsing inflammatory disorders of the gastrointestinal tract with a mostly unknown etiology.The incidence and prevalence of IBD are continually increasing,indicating the need for further studies to investigate the genetic determinants of these diseases.Since microRNAs(miRNAs)regulate protein translation via complementary binding to mRNA,discovering differentially expressed miRNAs(DE)in UC or CD patients could be important for diagnostic biomarker identification,assisting in the appropriate disease differentiation progressing the understanding of IBD pathogenesis.AIM To determine the miRNA expression profile in UC and CD patients and the potential pathophysiological contributions of differentially expressed miRNA.METHODS A total of 20 formalin-fixed paraffin-embedded colonic samples were collected from the Pathology Department of Botucatu Medical School at São Paulo State University(Unesp).The diagnosis of UC or CD was based on clinical,endoscopic,radiologic,and histological criteria and confirmed by histopathological analysis at the time of selection.The TaqMan™Array Human MicroRNA A+B Cards Set v3.0(Applied Biosystems™)platform was used to analyze 754 miRNAs.Targets of DE-miRNAs were predicted using miRNA Data Integration Portal(mirDIP)and the miRNA Target Interaction database(MiRTarBase).All statistical analyses were conducted using GraphPad Prism software.Parametric and nonparametric data were analyzed using t-tests and Mann-Whitney U tests,respectively.RESULTS The results showed that of the 754 miRNAs that were initially evaluated,643 miRNAs were found to be expressed in at least five of the patients who were diagnosed with either CD or UC;the remaining 111 miRNAs were not considered to be expressed in these patients.The expression levels of 28 miRNAs were significantly different between the CD and UC patients(P≤0.05);13 miRNAs demonstrated a fold-change in expression level greater than 1.Five miRNAs with a downregulated expression were selected for enrichment analysis.The miRNAs whose expression levels were significantly lower in UC patients than in CD patients were enriched in certain signaling pathways that were mostly correlated with cancer-related processes and respective biomarkers.CONCLUSION MiRNAs could be used to differentiate UC from CD,and differently expressed miRNAs could help explain the distinct pathophysiology of each disease. | Ana Elisa Valencise Quaglio Felipe Jose Santaella Maria Aparecida Marchesan Rodrigues Ligia Yukie Sassaki Luiz Claudio Di Stasi | 2021 | World Journal of Gastroenterology2021，27，45： | 3 |
| 4 | MicroRNA expression in inflammatory bowel disease-associated colorectal cancer显示文摘MicroRNAs(miRNAs)are non-coding RNA molecules composed of 19–25 nucleotides that regulate gene expression and play a central role in the regulation of several immune-mediated disorders,including inflammatory bowel diseases(IBD).IBD,represented by ulcerative colitis and Crohn’s disease,is characterized by chronic intestinal inflammation associated with an increased risk of colorectal cancer(CRC).CRC is one of the most prevalent tumors in the world,and its main risk factors are obesity,physical inactivity,smoking,alcoholism,advanced age,and some eating habits,in addition to chronic intestinal inflammatory processes and the use of immunosuppressants administered to IBD patients.Recent studies have identified miRNAs associated with an increased risk of developing CRC in this population.The identification of miRNAs involved in this tumorigenic process could be useful to stratify cancer risk development for patients with IBD and to monitor and assess prognosis.Thus,the present review aimed to summarize the role of miRNAs as biomarkers for the diagnosis and prognosis of IBD-associated CRC.In the future,therapies based on miRNA modulation could be used both in clinical practice to achieve remission of the disease and restore the quality of life for patients with IBD,and to identify the patients with IBD at high risk for tumor development. | Thais Gagno Grillo Ana Elisa Valencise Quaglio Rodrigo Fedatto Beraldo Talles Bazeia Lima Julio Pinheiro Baima Luiz Claudio Di Stasi Ligia Yukie Sassaki | 2021 | World Journal of Gastrointestinal Oncology2021，13，9： | 2 |
| 5 | Implementation of a flexible LDPC decoder显示文摘 | Guido Masera Federico Quaglio Fabrizio Vacca | 2007 | IEEE Trans on Circuit & System II2007，54，6： | 1 |
| 6 | Implementation of a flexible LDPC decoder显示文摘 | Masera G Quaglio F and Vacca F | 2007 | IEEE Transactions on Circuits System Ⅱ: Express Briefs2007，54，6： | 1 |
| 7 | Implementation of a Flexible LDPC Decoder 显示文摘 | MASERA G QUAGLIO F VACCA F | 2007 | IEEE Transanction on Circuits and Systems II : Express Briefs2007，54，6： | 1 |
| 8 | Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease显示文摘 | Torres LL Quaglio NB De Souza GT | | Journal of Alzheimer's Disease0，，： | 1 |
| 9 | Accumulation of protease - resistant priori protein (PrP) and apoptosis of cerebetlar granule cells in transgeuic mice expressing a PrP insertional mutation 显示文摘 | CHIESA R DRISALDI B QUAGLIO E | 2000 | PNAS2000，97，10： | 1 |
| 10 | Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment 显示文摘 | Quaglio G Lugoboni F Pattaro C | 2008 | Drug Alcohol Depend2008，94，13： | 1 |
| 11 | Patients in long-term maintenance therapy for drug use in Italy: analysis of some parameters of social integration and serological status for infectious diseases in a cohort of 1091 patients显示文摘 | Quaglio G Lugoboni F Pattarn C | 2006 | BMC Public Health2006，6，1： | 1 |
| 12 | Immunogenici- ty, reactogenicity and adherence to a combined hepatitis A and B vaccine in illicit drug users 显示文摘 | Lugoboni F Quaglio G Pajusco B etal | 2004 | Addiction2004，99，12： | 1 |
| 13 | Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform显示文摘 | Quaglio E Chiesa R Harris D A | 2001 | J Biol Chem2001，276，11： | 1 |
| 14 | Accumulation of proteaseresistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation 显示文摘 | Chiesa R Drisaldi B Quaglio E | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 15 | Implementation of a Flex- ible LDPC Decoder显示文摘 | Masera G Quaglio F Vacca F | 2007 | IEEE Transactions on Circuits and Systems II:Express Briefs2007，54，： | 1 |
| 16 | Reac- tive ion etching induced damage evaluation for optoelectronic device fabrication 显示文摘 | MORELLO G QUAGLIO M MENEGHINI G | 2006 | Journal of Vacuum Science &- Tech- nology B: Microelectronics and Nanometer Structures2006，24，2： | 1 |
| 17 | Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease显示文摘 | Torres LL Quaglio NB de Souza GT | 2011 | J A1- zheimers Dis2011，26，： | 1 |
| 18 | Compliance with hepatitis B vaccination in 1175 heroin users and risk factors associated with lack of vaccine response显示文摘 | Quaglio G Talamini G | 2002 | Addiction2002，97，8： | 1 |
| 19 | Effect of Eucalyptus Essential Oil on Respiratory Bacteria and Viruses显示文摘 | Claudio Cermelli Anna Fabio Giuliana Fabio Paola Quaglio | 2008 | Current Microbiology2008，，1： | 1 |
| 20 | Compliance with hepa- titis B vaccination in 1175 heroin users and risk factors associated with lack of vaccine response 显示文摘 | Quaglio G Talamini G Lugoboni F | 2002 | Addiction2002，97，8： | 1 |
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