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| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | OPTICAL PROPERTIES OF GeO_2 AND Ge NANOCRYSTALS显示文摘he co m pound m aterial of n m size particles Ge O2 Si O2 w as synthesied through hydrolysis of Si( O C2 H4) and Ge Cl4 . A heat treatm ent w as carried out for the sa m ples at 100 ~1200 ℃in air . Its optical property w as deter mined by U V Vis spectur m . We have found that theabsorption edge of spectru m shifted progressively to longer w avelengths . The quantu m size ef fect of nanocrystals appears because crystals gro w and energy of optical band gap reduces d ueto the influence of te m perature . By the analysis of X ray diffraction w e have observed theprocess in w hich the structure of particles changed fro m disorder into order . | Y.H.Zhou 1) ,Y.Y.Feng 2) and H.Y.Lu 2) 1)Department of Physics Nanjing Normal University, Nanjing 210097,China 2)Physics and Ch寁O P T I C A L P R O P E R T I E S O F Ge O2 A N D Ge N A N O C R Y S T A L S Y. H. Zhou1) , Y. Y. Feng2) | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 22 |
| 3 | Reconstructing mean maximum temperature of growing season from the maximum density of the Schrenk Spruce in Yili,Xinjiang,China显示文摘To study the historical temperature variation in Yili of Xinjiang,the tree-ring chronologies of maximum density(MXD) and tree-ring width(TRW) were established with the Schrenk Spruce(Picea schrenkiana Fisch.et Mey) collected from six sites to analyze the characteristics and ability of response to climate change.The results suggest that the MXD chronology of the Schrenk Spruce from different sampling sites responded to climate change well and were positively correlated with the mean maximum temperature and the mean temperature from April to August in the study area.The mean maximum temperature anomaly from April to August,spanning the years from 1848 to 2000,was reconstructed by three MXD chronologies which were selected by stepwise regression.The reconstructed function was stable and explained 56.2% of the variance.The reconstructed results indicated a cold span of 153 years in spring and summer from the beginning of the 1950s to the beginning of the 1970s in the Yili valley.No strongly increasing tendency was detected in the mean maximum temperature anomaly from April to August during this reconstructed period. | CHEN Jin1,2,3,WANG LiLi1,4,5,ZHU HaiFeng1 & WU Pu1 1 Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Sciences,Beijing 100101,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Institute of Vertebrate Paleontology and Paleoanthropology,Chinese Academy of Sciences,Beijing 100044,China 4 Institute of Tibetan Plateau Research,Chinese Academy of Sciences,Beijing 100085,China 5 Institute of Desert and Meteorology,China Meteorological Administration,ürümqi 830002,China | 2009 | Chinese Science Bulletin2009，54，13： | 21 |
| 4 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 5 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 6 | Optimal controlled teleportation via several kinds of three-qubit states显示文摘The probability of successful controlled teleportation of an unknown qubit using a general three-particle state is investigated. The analytic expressions of maximal probabilities via several kinds of tripartite states are given, including a tripartite Greenberger-Horne-Zeilinger state and a tripartite W-state. | GAO Ting1,2, YAN FengLi2,3 & LI YouCheng3 1 College of Mathematics and Information Science, Hebei Normal University, Shijiazhuang 050016, China 2 Max-Planck-Institut für Quantenoptik, Hans-Kopfermann-Str. 1, D-85748 Garching, Germany 3 College of Physics and Information Engineering, Hebei Normal University, Shijiazhuang 050016, China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，10： | 9 |
| 7 | Influence of Long-Term Fertilization with Different Mineral Fertilizers and Farmyard Manure on Some Soil Chemical Properties and Crop Yields显示文摘Longtermexperimentshaveaspecialvalueforprovidinginformationtoguideagriculturaldevelopments.Asearlyasin1843,LawesandGilbertes... | LIU DEHUI 1, J. LABETOWICZ 2 and L. KUSZELEWSKI 2 1 Nanjing Agricultural University, Nanjing 210095 (China) 2 Department of Agricultural Chemistry, Warsaw Agricultural University, Warsaw 02 528 (Poland) (Received February 15, 1998 r | 1998 | Pedosphere1998，8，3： | 8 |
| 8 | Enhancing disease resistances of Super Hybrid Rice with four antifungal genes显示文摘A plant expression vector harboring four antifungal genes was delivered into the embryogenic calli of ‘9311’, an indica restorer line of Super Hybrid Rice, via modified biolistic particle bombardment. Southern blot analysis indicated that in the regenerated hygromycin-resistant plants, all the four anti-fungal genes, including RCH10, RAC22, β-Glu and B-RIP, were integrated into the genome of ‘9311’, co-transmitted altogether with the marker gene hpt in a Mendelian pattern. Some transgenic R1 and R2 progenies, with all transgenes displaying a normal expression level in the Northern blot analysis, showed high resistance to Magnaporthe grisea when tested in the typical blast nurseries located in Yanxi and Sanya respectively. Furthermore, transgenic F1 plants, resulting from a cross of R2 homo-zygous lines with high resistance to rice blast with the non-transgenic male sterile line Peiai 64S, showed not only high resistance to M. grisea but also enhanced resistance to rice false smut (a disease caused by Ustilaginoidea virens) and rice kernel smut (another disease caused by Tilletia barclayana). | ZHU HuaChen1, XU XinPing1, XIAO GuoYing2,3, YUAN LongPing2 & LI BaoJian1 1 Biotechnology Research Center, Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China 2 China National Hybrid Rice R&D Center, Hunan Hybrid Rice Research Center, Changsha 410125, China 3 Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha 410125, China | 2007 | Science China(Life Sciences)2007，50，1： | 6 |
| 9 | The influence of impurity on the critical thickness of the CeO_2 buffer layer for coated conductors显示文摘The lattice parameters, band structure, density of state and elastic constant of RE-doped CeO2 (RE=Sm, Gd, Dy), the buffer material for coated HTS conductors, are calculated using the plane-wave method with pseudopotentials based on the density functional theory (DFT) of first-principle. The rule and mechanism of the effect of rare earth impurity on the critical thickness of the CeO2 buffer layer are investigated. It is found that, in the range of the calculation, the changes of the lattice volume V and elastic constant E of CeO2 with the impurity are mainly determined by the increased electrons ne of the system. The relationship of the elastic constant E and increased electrons ne is established. It is indicated that the critical thickness of the CeO2 single buffer layer doped with Sm, Gd, and Dy may be enhanced by 22%, 43% and 33%, respectively. | PAN Min1, HUANG Zheng2, MA HuanFeng2, QIANG WeiRong2, WEI LianFu1, WANG Long2 & ZHAO Yong1,3 1 Key Laboratory of Magnetic Levitation Technologies and Maglev Trains (Ministry of Education of China), Superconductivity R&D Center (SRDC), Southwest Jiaotong University, Chengdu 610031, China 2 School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, China 3 Superconductivity Research Group, School of Materials Science and Engineering, University of New South Wale, Sydney, 2052 NSW, Australia | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，7： | 3 |
| 10 | The level of oncogene H-Ras correlates with tumorigenicity and malignancy显示文摘Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T and H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR of retrovirrus can induce highly malignant and fast growing tumors, while lower levels of Ras derived from internal ribosome entry site(IRES) promotes slower tumor growth and loss of malignancy. Ras derived from CMV promoters resulted in much lower Ras levels and loss of tumor malignancy and growth. Further studies showed that the tumors formed in the presence of lower levels of Ras and dominant negative P53(P53DD) had fewer apoptotic cells and grew faster than the tumors formed from cells with same level Ras and SV40T. Our studies suggest that low levels of Ras are insufficient to inhibit apoptosis induced by pRb inactivation. In contrast, high levels of Ras not only allow normal cells to exit senescence and form tumors, but also protect against pRb inhibition-induced cell apoptosis. | Sun, B. C. Gao, Y. Deng, L. Li, G. Q. Cheng, F. Wang, X. H. Nanjing Med Univ, Liver Transplantat Ctr, Affiliated Hosp 1, Jiangsu 210029, Peoples R China. Nanjing Med Univ, Liver Transplantat Ctr, Ctr Canc, Jiangsu 210029, Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 3 |
| 11 | Surface Activities of Calix [4]resorcinarenes Bearing Four Hydrophobic Chains and Its Solubilization for Organic Compounds显示文摘Calix resorcinarenes bearing four hydrophobic side chains ( Ar-Rn, Ar-Ph, and Ar-N) orient stably on water oil interface and show high solubilization capacities for organic compounds, such as long chain alcohols, benzene, toluene and dyes. The capacities are high even near the cmc of polyalkylated calix resorcinarenes, but the solubilities of organic compounds(solubilizates) decrease with the increase of the size of the solubilizates. Ar-R 6, with a chain length of six carbons, is the most effective among Ar-R n , Ar-Ph, and Ar-N; 11 fold mol of hexanol is dissolved in 2×10 -3 mol/L Ar-R 6. Moreover, Ar-R n bearing four alkyl side chains solubilizes the chain alcohols of the same chain length mostly. The solubilization capacities are presumably brought by inclusion in a large cavity of the polyalkylated calix resorcinarenes and by an efficient orientation of the solubilizates. | LI Bo *1 , Yoshifumi KOIDE 1 and Kunio ESUMI 21. Toyota Central R & D Labs., Inc., 41 1, Yokomichi, Nagakute, Aichi 480 1192, Japan 2. Departemnt of Applied Chemistry and Institute of Colloid and Interface Science, Science University of Tokyo | 2002 | Chemical Research in Chinese Universities2002，18，2： | 3 |
| 12 | A Coupled Variable Coefficient Modified KdV Equation Arising from a Two-Layer Fluid System显示文摘A quite general coupled variable coefficient modified KdV (VCmKdV) equation in a two-layer fluid systemis derived by means of the reductive perturbation method.Making use of the CK's direct method,some similarityreductions of the coupled VCmKdV equation are obtained and their corresponding group explanations are discussed.Some exact solutions of the coupled equations are also presented. | GAO Yuan~1 and TANG Xiao-Yan~(1,2)~1 Department of Physics,Shanghai Jiao Tong University,Shanghai 200240,China~2 Institut Für Theoretische Physik IV,Fakultt für Physik und Astronomie,Ruhr-Universitt Bochum,D-44870 Bochum,Germany | 2007 | Communications in Theoretical Physics2007，，12： | 3 |
| 13 | Bioavailability and toxicity of cadmium to microorganisms and their activities in soil: a review显示文摘 | K Vig M Megharaj N Sethunathan R Naidu 1 | 2002 | Advances in Environmental Research2002，，1： | 2 |
| 14 | Cesium accumulation by bacterium Thermus sp. TibetanG7:hints for biomineralization of cesium-bearing geyserite in hot springs in Tibet,China显示文摘The bacterium Thermus sp. TibetanG7, isolated from hot springs in Tibet, China, was examined for the ability to accumulate cesium from solutions. Environmental conditions were simulated and the effects of pH, K+, Na+ and K+-regimes were then studied to determine the possible role of the bacterium in the formation of cesium-bearing geyserite around these hot springs. In despite of the inhibition of K+ and Na+, the bacterium Thermus sp. TibetanG7 revealed noticeable accumulation of cesium from solutions, with maximum accumulations of 53.49 and 40.41 μmol Cesium/g cell dry weight in Na+ and K+ inhibition experiments, respectively. The accumulation of cesium by this microorganism is rapid, with 40%―50% accumulated within the first 5 min. K+-deficient cells showed a much higher capacity of cesium accu- mulation compared with K+-sufficient cells. It is evident that the bacteria within the genus thermus play a significant role in the cesium assembly. The formation of cesium-bearing geyserite is also considered. | WANG HaiLei1,2,3, ZHENG MianPing1,2,3 & HUANG XiaoXing4 1 Institute of Mineral Resources, Chinese Academy of Geological Sciences (CAGS), Beijing 100037, China 2 R&D Center for Saline Lake and Epithermal Deposits, CAGS, Beijing 100037, China 3 Open Laboratory of Saline Lake Resourses and Environment, CAGS, Beijing 100037, China 4 Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100081, China | 2007 | Chinese Science Bulletin2007，52，19： | 2 |
| 15 | Licensing of university innovations: The role of a technology transfer office 显示文摘 | MACHO - STADLER 1 P? REZ - CASTRILLO D VEUGELERS R | 2007 | International Journal of Industrial Organization2007，25，： | 1 |
| 16 | Tumor necrosis factor induction by an aqueous phenol-extracted lipopolysac-charide complex from Bacteroides species 显示文摘 | Delahooke D M Barclay G R Poxton 1 R | 1995 | Infect Immun1995，63，3： | 1 |
| 17 | Architectural correlates of exploitation efficiency显示文摘 | Fitter A H Stickland T R Harvey M L etaL Architectural analysis of plant root systems 1 | 1991 | New Phytol1991，118，： | 1 |
| 18 | Cardiac re-modeling and failure : from molecules to man ( Part 1 ) 显示文摘 | Fedak 1' W Verma S Weisel R D | 2005 | Cardiovasc: Pathol2005，14，： | 1 |
| 19 | Role-Based Administration of User-Role Assignment: The URA97 Model and its Oracle Implementation显示文摘 | SANDHU R BHAM1D1PAT 1 | 1999 | Journal of Computer Security1999，，7： | 1 |
| 20 | Depression and cardiovascular diseases显示文摘 | 1,AromaaA Raitasalo R Impivaara O | 1994 | ActaPsychiatr Scand1994，，： | 1 |
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