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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot study显示文摘 | Gian Tontini Jonas Mudter Michael Vieth Raja Atreya Claudia Günther Yurdagül Zopf Dane Wildner Ralf Kiesslich Maurizio Vecchi Markus Neurath Helmut Neumann | 2014 | Endoscopy2014，，： | 2 |
| 3 | Influence of Magnetic Field on the Performance of Bubble Columns and Airlift Bioreactor with Submersed Microorganisms 显示文摘 | Raja R T B M L Sonolikar R L Saheb S P | 1997 | Chemical Engineering Science1997，5，2021： | 1 |
| 4 | Clinical significance of mi- crometastases detection in lymph nodes from head and neck squamous ceil carcinoma 显示文摘 | Ferris R Xi L Raja S | 2008 | Otolaryngol Head Neck Surg2008，139，3： | 1 |
| 5 | Simulations of Direct-Current Air Glow Discharge at Pressures - 1 Torr: Discharge Model Validation显示文摘 | Mahadevan S Raja L L | 2010 | JOURNAL OF APPLIED PHYS- ICS2010，107，9： | 1 |
| 6 | Anli-inllamlnatoryproperty of Kalpaamruthaa on myocardium in type 2 diabe- tes mellitus induced cardiovascular complication 显示文摘 | Raja L Palanivelu S Panchanatham S | 2012 | Im- munopharmacol Immunotoxicol2012，35，1： | 1 |
| 7 | Technology for automated, rapid,and quantitative PCR or reverse transcription-PCR clinical testing显示文摘 | Raja S Ching J Xi L | 2005 | Clin Chem2005，51，5： | 1 |
| 8 | Negative regulation of EGFR-Vav2signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediatedepithelial cell adherens junction dynamics and cell migration显示文摘 | Duan L Raja SM Chen G | 2011 | JBiol Chem2011，286，1： | 1 |
| 9 | Market structure and performance in automobile insurance显示文摘 | Bajtelsmit Vickie L Raja Bouzouita | 1998 | Journal of Risk and Insurance1998，65，3： | 1 |
| 10 | Computational study of capacitively coupled high-pressure glow discharges in helium显示文摘 | Yuan X Raja L L | 2003 | IEEE Transac tions on Plasma Science2003，31，4： | 1 |
| 11 | Treatment of acute postoperative pain显示文摘 | Wu C L Raja S N | 2011 | The Lancet2011，377，9784： | 1 |
| 12 | Functionally suppressive CD8+ T regulatory cells are increased in patients with multiple myeloma:a cause for immune impairment显示文摘 | Muthu Raja KR Kubiczkova L Rihova L | 2012 | PLoS One2012，7，49： | 1 |
| 13 | Synthesis,characterization,and catalytic properties of amicroporous/mesoporous material,MMM-1显示文摘 | RAJA H P POLADI R CHRISTOPHER C L | 2002 | J SolidState Chem2002，167，： | 1 |
| 14 | Enhancement of heat transfer using nanofluids-an overview显示文摘 | Lazarus Godson B Raja L D Mohan | 2010 | Renewable and Sustainable Energy Reviews2010，14，： | 1 |
| 15 | Two-dimensional simulation of a direct-current microhollow cathode discharge 显示文摘 | Kothnur P S Raja L L | 2005 | Journal of Applied Physics2005，97，043305： | 1 |
| 16 | 查看详情显示文摘 | Huang L Dolai S Raja K Kruk M | | 0，，04： | 1 |
| 17 | Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics显示文摘 | Hefnawy T E Raja S Kelly L | 2004 | Clinical Chemistry2004，50，3： | 1 |
| 18 | Laser-induced breakdown speetroseopy analysis of lunar simulants under high vacuum conditions显示文摘 | ANTONY J K VASA N J SRIDHAR RAJA V L N | 2010 | TENCON2010，，4： | 1 |
| 19 | Molecular staging of cervical lymphnodes in sequamous cell carcinoma of the head and neck显示文摘 | FERRIS R XI L RAJA S | 2005 | Cancer Res2005，65，6： | 1 |
| 20 | Characteriza- tion of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics 显示文摘 | EI-Hefnawy T Raja S Kelly L | 2004 | Clin Chem2004，50，3： | 1 |
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