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| 1 | Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis显示文摘AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated cirrhosis.METHODS: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 mo.RESULTS: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show any significant difference(P =0.60) when compared to the control group. There was no improvement in aspartate transaminase, alanine transaminase, and bilirubin at any point in the study population. There was no mortality benefit in the study group. The procedure was safe with no procedural or treatment related complications.CONCLUSION: Autologous CD 34+ cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. | Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata Reddy Kuncharam Chimpa Reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，23： | 9 |
| 2 | Changes in lipids, proteins and kamaboko forming ability of silver carp ( Hypophthalmichthys molitrix ) mince during frozen storage显示文摘 | D Siddaiah G.Vidya Sagar Reddy C.V Raju T.C Chandrasekhar | 2001 | Food Research International2001，，1： | 2 |
| 3 | Trigogellafoenum graecum (fenugreek) seed power improves glucose homeostasis in alloxan diabetic rat tissues by altered glyeotie, glueoneogenic and lipogenie enzymes 显示文摘 | Raju J Gupta D Rao AR | 2001 | Mol Cell Bioehem2001，224，12： | 1 |
| 4 | Breast pallilloma with atypical ductal hyperplasia:a clinicopathologic study显示文摘 | Raju U Verrtes D | 1996 | Hum Pathol1996，27，11： | 1 |
| 5 | 查看详情显示文摘 | Chattopadhyay D Sreedhar B Raju K | | 0，，： | 1 |
| 6 | Structural engineering of polyurethane coatings for high performance applications 显示文摘 | Chattopadhyay D K Raju K V S N | 2007 | Progress in Polymer Science2007，32，： | 1 |
| 7 | Hematopoietic stem/progenitor cell haversting form umbilical cord blood显示文摘 | Nayar B GMK Raju D Deka | 2002 | Int J Gynecol Obstetr2002，79，： | 1 |
| 8 | Synthesis and characterization of hyperbranehed polyurethane-urea coatings 显示文摘 | Jena K K Chattopadhya Y D K Raju K V S N | 2007 | European Polymer Journal2007，43，5： | 1 |
| 9 | Structural engineering of polyurethane coatings for high performance applications显示文摘 | CHATTOPADHYAY D K RAJU K V S N | 2007 | Progress in Polymer Science2007，32，3： | 1 |
| 10 | Synthesis and characterization of hyperbranched polyurethane - urea coatings 显示文摘 | JENA K K CHATTOPADHYAY D K RAJU K V S N | 2007 | European Polymer Journal2007，43，5： | 1 |
| 11 | Structural engineering of polyurethane coatings for high performance applications显示文摘 | Chattopadhyay D K Raju KVS N | 2007 | Progress in Polymer Science2007，32，： | 1 |
| 12 | Forest fire risk zone map- ping from satellite imagery and GISE 显示文摘 | Jaiswal R K Mukherjee S Raju K D | 2002 | International Journal of Ap- plied Earth Observation and Geoinforma~ion2002，4，1： | 1 |
| 13 | The phase mixing studies on moisture cured polyurethane-ureas during cure显示文摘 | Chattopadhyay D K Sreedhar B Raju K V | 2006 | Polymer2006，47，： | 1 |
| 14 | Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model:role of the oxygenase in protection against oxidative injury显示文摘 | Raju V S | 1999 | Pharmacol Exp Ther1999，291，2： | 1 |
| 15 | Structural En- gineering of Polyurethane Coatings for High Perform- ance Applications 显示文摘 | CHATTOPADHY D K RAJU K V S N | 2007 | Progress in Polymer Science2007，32，3： | 1 |
| 16 | The phase mixing studies on moisture cured polyurethane- urea during cure显示文摘 | CHATFOPADHYAY D K SREEDHAR B RAJU K V S N | 2006 | Polymer2006，47，11： | 1 |
| 17 | Optimizing care and out-come for late-preterm(near-term)infants:a summary of the workshopsponsored by the National Institute of Child Health and Human Devel-opment显示文摘 | Raju T N Higgins R D Stark A R | 2006 | Pediatrics2006，118，3： | 1 |
| 18 | Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans显示文摘 | Raju D Hussey S Jones NL | 2012 | Autophagy2012，8，： | 1 |
| 19 | Echocardiographic assessment of right ventricular function in inferior wall myocardial infarction and an- giographic correlation to proximal right coronary artery stenosis 显示文摘 | Rajesh GN Raju D Nandan D | 2013 | Indian Heart J2013，65，5： | 1 |
| 20 | Changes in lipids,proteins and kamaboko forming ability of silver carp(Hypophthalmichthys molitrix)mince during frozen storage显示文摘 | Siddaiah D Sagar Reddy G V Raju C | 2001 | Food Research International2001，34，1： | 1 |
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