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| 1 | Real time endoscopic ultrasound elastography and strain ratio in the diagnosis of solid pancreatic lesions显示文摘AIM To evaluate the accuracy of the elastography score combined to the strain ratio in the diagnosis of solid pancreatic lesions(SPL). METHODS A total of 172 patients with SPL identified by endoscopic ultrasound were enrolled in the study to evaluate the efficacy of elastography and strain ratio in differentiating malignant from benign lesions. The semi quantitative score of elastography was represented by the strain ratio method. Two areas were selected, area(A) representing the region of interest and area(B) representing the normal area. Area(B) was then divided by area(A). Sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV), and accuracy were calculated by comparing diagnoses made by elastography, strain ratio and final diagnoses.RESULTS SPL were shown to be benign in 49 patients and malignant in 123 patients. Elastography alone had a sensitivity of 99%, a specificity of 63%, and an accuracy of 88%, a PPV of 87% and an NPV of 96%. The best cut-off level of strain ratio to obtain the maximal area under the curve was 7.8 with a sensitivity of 92%, specificity of 77%, PPV of 91%, NPV of 80% and an accuracy of 88%. Another estimated cut off strain ratio level of 3.8 had a higher sensitivity of 99% and NPV of 96%, but with less specificity, PPV and accuracy 53%, 84% and 86%, respectively. Adding both elastography to strain ratio resulted in a sensitivity of 98%, specificity of 77%, PPV of 91%, NPV of 95% and accuracy of 92% for the diagnosis of SPL. CONCLUSION Combining elastography to strain ratio increases the accuracy of the differentiation of benign from malignant SPL. | Hussein Okasha Shaimaa Elkholy Ramy El-Sayed Mohamed-Naguib Wifi Mohamed El-Nady Walid El-Nabawi Waleed A El-Dayem Mohamed I Radwan Ali Farag Yahya El-sherif Emad Al-Gemeie Ahmed Salman Mohamed El-Sherbiny Ahmed El-Mazny Reem E Mahdy | 2017 | World Journal of Gastroenterology2017，23，32： | 11 |
| 2 | Hepatocellular carcinoma in Lebanon: Etiology and prognostic factors associated with short-term survival显示文摘瞄准:在黎巴嫩和早死亡预兆的预示的因素学习 HCC 的传染病学。方法:在一个五年的时期上诊断的 HCC 盒子的观察后续队研究被执行。Multivariate 分析被进行与肝意大利的程序(片断) 分数的癌症相比识别预示的因素。包括内在的肝疾病,病人的人口统计的特征,和孩子呸评估的肝疾病的严厉的病原学的多重变量得分被学习。肿瘤参数包括了小瘤,门静脉血栓的存在,和治疗形式的 HCC, alpha-fetoprotein 水平,数字和尺寸的诊断的时间。后续的死亡或损失被看作一个端点事件。结果:92 个病人(平均数 60.5 +/- 22.3 年) 被包括。内在的疾病的病原学分别地是在 67% , 20% ,和 23.5% 的肝炎 B, C,和酒精。在诊断的孩子呸班分别地是在 34.8% , 39.3% 和 25.8% 的 A, B,和 C。全面幸存分别地在 1, 2 和 3 年是 44.8% , 32.8% 和 17.6%( 吝啬的 F/U 40.2 +/- 23.5 瞬间) 。Multivariate 分析识别了早死亡的三个预言者(<
6 瞬间) :胆红素 >
3.2 mg/dL (P <
0.01 ) , HCC 作为肝疾病的第一个演讲(P = 0.035 ) ,并且肌酸酐 >
1 mg/dL (P = 0.017 ) 。一个分数由考克斯基于这些变量超过了片断分数比例的危险。巨鸟曲线显示了两个模型相等、中等精确。结论:HBV 是在黎巴嫩的 HCC 的领先的原因。早死亡的独立预言者是象疾病的第一表明的提高的胆红素,肌酸酐和 HCC。一个分数的未来的确认基于在预言短期的幸存的这些临床的参数被需要。 | César Yaghi Ala I Sharara Paul Rassam Rami Moucari Khalil Honein Joseph BouJaoude Rita Slim Roger Noun Heitham Abdul-Baki Mohamad Khalifeh Sami Ramia Raymond Sayegh | 2006 | World Journal of Gastroenterology2006，12，22： | 3 |
| 3 | Assessment of lnc RNA GAS5, lnc RNA HEIH, lnc RNA BISPR and its m RNA BST2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4显示文摘BACKGROUND Hepatitis C virus(HCV)infection and its consequent complications are undeniably a public health burden worldwide,particularly in Egypt.Emerging evidence suggests that many lncRNAs have relevant roles in viral infections and antiviral responses.AIM To investigate the expression profiles of circulating lncRNAGAS5,lncRNAHEIH,lncRNABISPR and mRNABST2 in naïve,treated and relapsed HCV Egyptian patients,to elucidate relation to HCV infection and their efficacy as innovative biomarkers for the diagnosis and prognosis of HCV GT4.METHODS One hundred and thirty HCV-infected Egyptian patients and 20 healthy controls were included in this study.Serum lncRNAs and mRNABST2 were measured using quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Our results indicated that serum lncRNAGAS5 and LncRNABISPR were upregulated,whereas mRNA BST2 and LncRNA HEIH were downregulated in naïve patients.In contrast,HCV patients treated with sofosbuvir and simeprevir;with sofosbuvir and daclatasvir;or with sofosbuvir,daclatasvir and ribavirin exhibited lower levels of lncRNAGAS5 and lncRNABISPR with higher mRNABST2 compared to naïve patients.Notably,patients relapsed from sofosbuvir and simeprevir showed higher levels of these lncRNAs with lower mRNABST2 compared to treated patients.LncRNAGAS5 and lncRNABISPR were positively correlated with viral load and ALT at P<0.001,whereas mRNABST2 was negatively correlated with viral load at P<0.001 and ALT at P<0.05.Interestingly,a significant positive correlation between lncRNA HEIH and AFP was observed at P<0.001.CONCLUSION Differential expression of these RNAs suggests their involvement in HCV pathogenesis or antiviral response and highlights their promising roles in diagnosis and prognosis of HCV. | Nourhan M El Samaloty Marwa I Shabayek Ramy S Ghait Shohda A El-Maraghy Sherine M Rizk Maha M El-Sawalhi | 2020 | World Journal of Gastroenterology2020，26，2： | 2 |
| 4 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 5 | Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia显示文摘 | Rami A Bechmann I Stehle J H | 2008 | Prog Neurobiol2008，85，3： | 1 |
| 6 | Exploiting endogenous anti - apoptotic proteins for novel therapeutic strategies in cerebral ischemia 显示文摘 | Rami A Bechmann I Stehle JH | 2008 | Prog Neurobiol2008，85，3： | 1 |
| 7 | Layout evaluation of large capacity warehouses显示文摘 | Huertas J I Rami rez J D Salazar F T | 2007 | Facilities2007，25，78： | 1 |
| 8 | Characterization and reactivity of V2Os-MoO3/TiO2 De-NOx SCR catalysts显示文摘 | Lietti L Nova I Ramis G | 1999 | Journal of Catal1999，187，2： | 1 |
| 9 | Lipohypertrophy in children and adole-scents with type 1 diabetes and the associated factors显示文摘 | Magdy AO Ahmed A Ramy I | 2011 | BMC Research Notes2011，8，4： | 1 |
| 10 | Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia显示文摘 | Rami A Bechman I StehleJH | | 0，，3： | 1 |
| 11 | Biorational insecticides: mechanism and cross resistance 显示文摘 | Isaac I Svetlana K Rami H | 2005 | Archives lnsec Bio Phy2005，58，： | 1 |
| 12 | Characterization and reactivity of V2O5-MoO2/TiO2 De-NOx SCiR catalysts显示文摘 | Lietti L Nova I Ramis G | 1999 | Journal of Catalysis1999，187，2： | 1 |
| 13 | Association of WWOX with ErbB4 in breast cancer 显示文摘 | Rami I Aqeilan Valentina Donati | 2007 | Cancer Res2007，67，： | 1 |
| 14 | Characterization and reactivity of V2O5-MoO3/TiO2 De-NOx SCR catalysts显示文摘 | Lietti L Nova I Ramis G | 1999 | Journal of catalysis1999，187，2： | 1 |
| 15 | Characterization and reactivity of V2Os-MoO3/TiO2 13e-NOx SCR catalysts显示文摘 | Lietti L Nova I Ramis G | 1999 | Journal of Catalysis1999，187，2： | 1 |
| 16 | Constitutive nuclear factorkappaB activity in human upper airway tissues and nasal epithelial cells显示文摘 | Ramis I Bioque G Lorente J | 2000 | Eur Respir J2000，15，： | 1 |
| 17 | Inhibitory activity of rupatadine on proinflamatory cytokine production,relationship with binding affinity显示文摘 | Barron S Ramis I GarciaRafanell J | 2005 | Methods Find Exp Clin Pharmacol2005，27，： | 1 |
| 18 | Post-ischemic activation of caspase-3 in the rat hippocampus:evidence of an axonal and dendritic localisation 显示文摘 | Rami A Jansen S Giesser I Winckler J | 2003 | J Neurochem Int2003，43，3： | 1 |
| 19 | One-year clinical evaluation of compomer restorations in cervical lesions of different aetiology 显示文摘 | Premovi? M Rami? B Stojanac I | 2012 | ned Pregl2012，65，34： | 1 |
| 20 | Differential activity of nitric oxide synthase in human nasal mucosa and polyps显示文摘 | Ramis I Lorente J Rosello-Catafau J | 1996 | Eur Respir J1996，9，2： | 1 |
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