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| 1 | Imaging evaluation of traumatic thoracolumbar spine injuries: Radiological review显示文摘Spine fractures account for a large portion of musculoskeletal injuries worldwide. A classification of spine fractures is necessary in order to develop a common language for treatment indications and outcomes. Several classification systems have been developed based on injury anatomy or mechanisms of action, but they have demonstrated poor reliability, have yielded little prognostic information, and have not been widely used. For this reason, the Arbeitsgemeinschaftfür Osteosynthesefragen(AO) committee has classified thorocolumbar spine injuries based on the pathomorphological criteria into3 types(A: Compression; B: Distraction; C: Axial torque and rotational deformity). Each of these types is further divided into 3 groups and 3 subgroups reflecting progressive scale of morphological damage and the degree of instability. Because of its highly detailed sub classifications, the AO system has shown limited interobserver variability. It is similar to its predecessors in that it does not incorporate the patient's neurologic status.The need for a reliable, reproducible, clinically relevant, prognostic classification system with an optimal balance of ease of use and detail of injury description contributed to the development of a new classification system, the thoracolumbar injury classification and severity score(TLICS). The TLICS defines injury based on three clinical characteristics: injury morphology, integrity of the posterior ligamentous complex, and neurologic status of the patient. The severity score offers prognostic information and is helpful in decision making about surgical vs nonsurgical management. | Shivanand Gamanagatti Deepak Rathinam Krithika Rangarajan Atin Kumar Kamran Farooque Vijay Sharma | 2015 | World Journal of Radiology2015，7，9： | 18 |
| 2 | Preliminary investigation on the antibacterial activity of mango(Mangifera indica L:Anacardiaceae) seed kernel显示文摘Objective:To evaluate the antibacterial activity of the methanolic extract of mango(Mangifera indica L) seed kernel.Methods:Chokanan mango seed kernel and seed kernels from assorted mango varieties were collected,cleaned,dried and powered.Crude methanolic extracts of mango seed kernel were analyzed for the phytochemical constituents.The free radical scavenging activity was determined by 2,2-Diphenyl-1-picrylhydrazyl(DPPH) assay.Antibacterial activity was evaluated by disc diffusion assay with three medically important bacterial pathogens such as methicillin resistant Staphylococcus aureus(S.aureus)(MRSA),Escherichia coli(E.coli) and Vibrio vulnificus(V.vulnificus).Results:Qualitative phytochemical analysis indicated the presence of important phytochemical compounds such as glycosides,saponins,flavanoids, tannins and alkaloids.There was no significant difference in the phytochemical content between the single and assorted mango seed kernels.However,the free radical scavenging study indicated that the assorted mango kernels showed slighdy higher activity than the single species(P<0.05). The crude methanolic extract of mango seed kernel at a concentration of 100 mg/mL is found to have potential antimicrobial activity against MRSA and E.coli compared to V.vulnificus. Study on the antibacterial activity also indicated that there was no significant difference in the antibacterial activity of the single and assorted mango seed kernel extracts.Conclusions:The present study conclusively demonstrates the free radical scavenging activity and antibacterial activities of mango seed kernel.In addition,the results also indicated that there is no significant difference in the phytochemical content and biological activity of mango kernels from single and assorted mango varieties. | Jasminder Kaur Xavier Rathinam Marimuthu Kasi Khoo Miew Leng Rajasekaran Ayyalu Kathiresan S Sreeramanan Subramaniam | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 11 |
| 3 | A comparative study on the antioxidant activity of methanolic leaf extracts of Ficus religiosa L,Chromolaena odorata(L.) King & Rabinson,Cynodon dactylon(L.) Pers.and Tridax procumbens L.显示文摘Objective:To compare the antioxidative effects of the methanolic leaf extracts of Ficus religiosa (F.religiosa),Chromolaena odorata(C.odorata),Cynodon dactylon(C.dactylon) and Trida,x procumbens(T.procumbens) as well as the contents of antioxidants in the extracts.Methods: Total phenol and total flavanoid contents were measured according to the standard procedures. The total antioxidant capacity was determined using the phosphomolybdenum method.Reducing power was determined by the potassium ferrieyanide reducing method.The free radical scavenging activity was measured by 2,2’-Diphenyl-l-picrylhydrazyl(DPPH) assay.Results: Quantitative phytochemical analysis of total phenol content showed that C.odorata had the highest content of phenolic compounds significantly followed by F.religiosa,T.procumbens and C.dactylon.As for the total flavanoids content,F.religiosa had the highest content,followed by C.odorata,T.procumbens and C.daxtylon.Study on the total antioxidant capacity revealed that F.religiosa,C.dactylon and C.odorata showed higher total antioxidant capacity.T.procumbens showed the lowest capacity.Meanwhile,T.procumbens and C.odorata have the highest reducing power activity followed by F.religiosa and C.dactylon.The results of DPPH radical scavenging activity indicated that T.procumbens induced the largest elevation as the concentration of its extract increased,followed by C.odorata and F.religiosa and C.dactylon.Conclusions:The present study demonstrates the antioxidative capacity of all the four plant species.Of all the plants,C.odorata,a perennial weed plant showed potentially a high antioxidant activity,with higher phenolic and flavonoids contents.The data suggest that C.odorata can be best utilized in developing bioantioxidants. | Melinda Krishanti P Xavier Rathinam Marimuthu Kasi Diwakar Ayyalu Ramanathan Surash Kathiresan Sadasivam Sreeramanan Subramaniam | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 6 |
| 4 | Isolation and identification of Salmonella from curry samples and its sensitivity to commercial antibiotics and aqueous extracts of Camelia sinensis(L.) and Trachyspermum ammi(L.)显示文摘Objective:To isolate Salmonella from curry samples and to evaluate the drug sensitivity of the food-borne Salmonella and its susceptibility to specific plant extracts.Methods:Salmonella was isolated from the curry samples by standard microbiological methods and was confirmed by biochemical tests.The antibiotic susceptibility test was conducted by disc diffusion method using commercially available antibiotics such as ampicillin,tetracycline,chloramphenicol,kanamycin,and penicillin.In addition,the susceptibility of the food-borne Salmonella was also evaluated against the aqueous extracts of Camelia sinensis(L.) Theaceae(tea leaves) and the Trachyspermum ammi(L.) Apiaceae(ajwain or omum seeds).Results:Out of fifty curry samples,only seven samples were identified to have Salmonella contamination.The Salmonella isolates showed a significant drug resistance pattern except for kanamycin.The plant extracts showed a considerable antibacterial activity against the isolates,indicating the presence of antimicrobial principle which can be exploited after complete pharmacological investigations.Conclusions:The present study demonstrates the occurrence of Salmonella in the curry samples,and shows significant drug resistance against most of the commercially available antibiotics,except kanamycin.Antimicrobial effect of the plant extracts against the food-bone Salmonella suggests that dietary including medicinal herbs would be one strategy to manage food borne pathogens. | Thanes Gunasegaran Xavier Rathinam Marimuthu Kasi Kathiresan Sathasivam Sasidharan Sreenivasan Sreeramanan Subramaniam | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 3 |
| 5 | 限制铬鞣过程中的用水量显示文摘工业生产如铬鞣常常需要耗费大量的水,导致全球需求的宝贵资源枯竭。而在胶原基质中铬的水解、扩散、分布和固定,水是必须的。虽然可以通过使用绿色溶剂如生物乙醇使铬鞣所需水量达到最小来获得比较绿色和可持续的解决方案,但这一问题已争议了数年。本研究通过冻干技术显示,对于铬鞣使胶原基质内部含水量最低55%~65%是必须的。通过光学和电子显微镜分析结合x一射线能谱分析证实,随着冷冻时间的延长,皮基质内含水量从65%降低到15%,铬在革中的含量与分布呈线性降低。 | Silambarasan Selvaraj Aravindhan Rathinam Raghava Rao Jonnalagadda 石永固 | 2015 | 西部皮革2015，0，16： | 2 |
| 6 | Role of Rho GTPases and their regulators in cancer progression显示文摘 | Rathinam R Berrier A Alahari SK | 2011 | Front Binsci2011，17，： | 1 |
| 7 | E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance 显示文摘 | Kriegel M A Rathinam C Flavell R A | 2009 | Proc Natl Acad Sci USA2009，106，16： | 1 |
| 8 | Autophagy proteins reg- ulate innate immune responses by inhibiting the release of mitoehon- drial DNA mediated by the NALP3 inflammasome显示文摘 | Nakahira K Haspel JA Rathinam VA | 2011 | Nat Immunol2011，12，3： | 1 |
| 9 | Global variation and pattern changes in epidemiology of uveitis显示文摘 | Rathinam SR Namperumalsamy P | 2007 | Indian J Ophthalmol2007，55，2： | 1 |
| 10 | Role of Rho GTPases and theirregulators in cancer progression显示文摘 | Rathinam R Berrier A Alahari SK | 2011 | Front Biosci2011，16，1： | 1 |
| 11 | Sensitivity of field isolates of Eimeria to Monensin in the Turkey 显示文摘 | Chapman H D Rathinam T | 2007 | Avian Dis2007，51，： | 1 |
| 12 | Autophagy pro- teins regulate innate immune responses by inhibiting the release of mitoehondrial DNA mediated by the NALP3 inf/ammasome 显示文摘 | Nakahira K Haspel JA Rathinam VA | 2011 | Nat Immunol2011，12，3： | 1 |
| 13 | The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses显示文摘 | Rathinam VA Jiang Z Waggoner SN | 2010 | Nat Immunol2010，11，5： | 1 |
| 14 | Role of Rho GTPases and their regulators in cancer progression显示文摘 | Rathinam R Berrier A Alahari SK | 2010 | Front Biosci(Landmark e- dition)2010，16，： | 1 |
| 15 | Introduction of vertical integration and case-based learning in anatomy for undergraduate physical therapy and occupational therapy students显示文摘 | Parmar SK Rathinam BA | 2011 | Anat Sci Educ2011，4，3： | 1 |
| 16 | The AIM2 inflamma-some is essential for host defense against cytosolic bacteria andDNA viruses 显示文摘 | Rathinam VA Jiang Z Waggoner SN | 2010 | Nat Immunol2010，11，5： | 1 |
| 17 | The effects of increased provision of thoracic surgical specialists on the variation in lung cancer resection rate in England 显示文摘 | Lau KK Rathinam S Waller DA | 2013 | J Thorac Oncol2013，8，1： | 1 |
| 18 | Autophagy pro-teins regulate innate immune responses by inhibiting the releaseof mitochondrial DNA mediated by the NALP3 inflammasome 显示文摘 | Nakahira K Haspel JA Rathinam VA | 2011 | Nat Immunol2011，12，3： | 1 |
| 19 | Green solution for tannery pollution:effect of enzyme based lime-free unhairing and fibre opening in combination with pickle-free chrome tanning显示文摘 | Subramani S Rathinam A Palanisamy T | 2003 | Green Chemistry2003，5，6： | 1 |
| 20 | The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stemcells 显示文摘 | Rathinam C Matesic LE Flavell RA | 2011 | Nat Immunol2011，12，5： | 1 |
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