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| 1 | 种植密度对玉米-大豆带状间作下大豆光合、产量及茎秆抗倒的影响显示文摘【目的】阐明玉米-大豆带状间作下大豆植株冠层在不同种植密度下的光环境变化规律,明确种植密度对间作大豆叶片光合特性、产量形成及茎秆抗倒的影响,为构建寡日照地区间作大豆合理群体密度提供理论参考。【方法】本研究以大豆(川豆-16)和玉米(正红-505)为试验材料。采用双因素随机区组设计,主因素为种植方式,设玉米-大豆带状间作和大豆带状单作2个水平,副因素为大豆的3个种植密度(PD1=17株/m^(2),PD2=20株/m^(2),PD3=25株/m^(2)),研究种植密度对间作大豆冠层内部光环境变化、叶片光合特性、植株生长动态、田间倒伏率及产量构成等的影响。【结果】2年结果表明,在玉米-大豆带状间作系统中,大豆生长中后期受高位作物玉米遮荫和自荫性增加的影响,其植株群体冠层内部的光合有效辐射(PAR)、叶面积指数(LAI)、叶片光合能力、分枝数及产量显著降低,但受玉米影响的程度因大豆种植密度的不同而不同。在间作模式下,PD1和PD2处理的大豆植株群体冠层光合有效辐射比PD3处理分别增加了45.4%和24.8%,净光合速率分别增加了46.1%和12.3%,单株有效荚数分别增加了53.2%和27.2%,单株分枝数分别增加了270.4%和140.9%,田间倒伏率分别降低了50.3%和19.3%。相关性分析发现,间作大豆的田间倒伏率与冠层内部光合有效辐射、叶片净光合速率、茎秆抗折力、茎叶干物质比、单株分枝数及单株有效荚数呈显著负相关,与株高、叶面积指数和单株无效荚数呈显著正相关。【结论】在玉米-大豆带状间作模式下,20株/m^(2)的大豆密度(PD2)有利于创造良好的群体冠层内部光环境,降低植株田间大豆倒伏率,增加光合产物积累,从而提高大豆产量。 | 程彬 刘卫国 王莉 许梅 覃思思 卢俊吉 高阳 李淑贤 Ali RAZA 张熠 Irshan AHMAD 敬树忠 刘然金 杨文钰 | 2021 | 中国农业科学2021，54，19： | 42 |
| 2 | 低温胁迫对玉米发芽及幼苗生理特性的影响显示文摘为探究低温胁迫对玉米发芽及幼苗生理特性影响,文章以杂交玉米品种天农9和天合1为试验材料,采用低温培养(发芽期6℃,苗期4℃)方法,分析低温胁迫下玉米发芽(发芽率)、幼苗农艺性状(株高、根长、地上部及地下部干鲜重)和生理生化指标(SPAD值、Pn、MDA含量、POD活性、SOD活性、脯氨酸含量和可溶性蛋白含量)变化。结果表明,低温胁迫抑制玉米种子发芽和幼苗生长,降低幼苗株高、根长、地上部地下部干鲜重、叶绿素含量和净光合速率提高MDA含量、POD活性、SOD活性、脯氨酸含量和可溶性蛋白含量。不同品种间差异显著,天合1对低温胁迫更敏感。研究成果为解决玉米生产冷害问题提供理论依据。 | 杨德光 孙玉珺 Ali Raza Irfan 刘昕萌 吕金莹 尉菊萍 宫磊 刘哲 白冰 | 2018 | 东北农业大学学报2018，49，5： | 36 |
| 3 | Hepatocellular carcinoma review:Current treatment,and evidence-based medicine显示文摘Hepatocellular carcinoma(HCC)is the fifth most common tumor worldwide.Multiple treatment options are available for HCC including curative resection,liver transplantation,radiofrequency ablation,trans-arterial chemoembolization,radioembolization and systemic targeted agent like sorafenib.The treatment of HCC depends on the tumor stage,patient performance status and liver function reserve and requires a multidisciplinary approach.In the past few years with significant advances in surgical treatments and locoregional therapies,the short-term survival of HCC has improved but the recurrent disease remains a big problem.The pathogenesis of HCC is a multistep and complex process,wherein angiogenesis plays an important role.For patients with advanced disease,sorafenib is the only approved therapy,but novel systemic molecular targeted agents and their combinations are emerging.This article provides an overview of treatment of early and advanced stage HCC based on our extensive review of relevant literature. | Ali Raza Gagan K Sood | 2014 | World Journal of Gastroenterology2014，20，15： | 39 |
| 4 | 仿人机器人复杂动态动作设计及相似性研究显示文摘提出了一种基于人体运动的考虑节奏相似性的仿人机器人复杂动态动作设计方法.首先,把人体的运动分割成基本动作段,给出了运动学约束,讨论了复杂动态动作的稳定性调节方法.然后,提出了考虑运动节奏的仿人机器人模仿人体动作的相似性函数,并给出了满足运动学约束和动力学稳定性、具有高相似性的运动轨迹求解方法.最后,通过在仿人机器人BHR-2上进行中国功夫“刀术”实验验证了该方法的有效性. | 张利格 黄强 杨洁 时有 王志杰 JAFRI Ali Raza | 2007 | 自动化学报2007，33，5： | 28 |
| 5 | Bacillus amyloliquefaciens Strain W19 can Promote Growth and Yield and Suppress Fusarium Wilt in Banana Under Greenhouse and Field Conditions显示文摘Plant growth-promoting rhizobacteria(PGPR) are considered to be the most promising agents for cash crop production via increasing crop yields and decreasing disease occurrence. The Bacillus amyloliquefaciens strain W19 can produce secondary metabolites(iturin and bacillomycin D) effectively against Fusarium oxysporum f. sp. cubense(FOC). In this study, the ability of a bio-organic fertilizer(BIO) containing strain W19 to promote plant growth and suppress the Fusarium wilt of banana was evaluated in both pot and field experiments. The results showed that application of BIO significantly promoted the growth and fruit yield of banana while suppressing the banana Fusarium wilt disease. To further determine the beneficial mechanisms of the strain, the colonization of green fluorescent protein-tagged strain W19 on banana roots was observed using confocal laser scanning microscopy and scanning electron microscopy. The effect of banana root exudates on the formation of biofilm of strain W19 indicated that the banana root exudates may enhance colonization. In addition, the strain W19 was able to produce indole-3-acetic acid(IAA), a plant growth-promoting hormone.The results of these experiments revealed that the application of strain W19-enriched BIO improved the banana root colonization of strain W19 and growth of banana and suppressed the Fusarium wilt. The PGPR strain W19 can be a useful biocontrol agent for the production of banana under field conditions. | WANG Beibei SHEN Zongzhuan ZHANG Fengge Waseem RAZA YUAN Jun HUANG Rong RUAN Yunze LI Rong SHEN Qirong | 2016 | Pedosphere2016，26，5： | 22 |
| 6 | 氨基酸螯合微肥对旱作水稻苗期生长及生理效应的影响显示文摘通过盆栽试验研究氨基酸螯合微肥(AA-M et)对旱作水稻苗期生长的影响。结果表明:AA-M et能显著提高旱作水稻的株高、根长及生物量。喷施后72 h内每24 h用SPAD-502测定叶绿素相对含量,发现旱作水稻对螯合态微肥的吸收同化速率显著大于无机微肥,但AA-M et与EDTA-M et(EDTA螯合微肥)间差异不显著。等量施用微量元素下,AA-M et和EDTA-M et处理的生物量、叶绿素和生长素含量均显著高于无机微肥处理,而两螯合态微肥处理间差异不显著。可溶性蛋白含量3种微肥处理间差异显著,表现为AA-M et处理>ED-TA-M et处理>无机微肥处理(P<0.05),表明AA-M et可完全替代EDTA-M et。分别喷施稀释100(AA-M et1)和250(AA-M et2)倍AA-M et的溶液时,作物生物量、叶绿素、生长素及可溶性蛋白含量两处理间差异不显著,但显著高于喷施稀释500(AA-M et)倍的AA-M et溶液的处理。 | 穆杰 徐阳春 朱培淼 Waseem Raza 沈其荣 | 2006 | 水土保持学报2006，20，5： | 21 |
| 7 | Association of genetic variants with diabetic nephropathy显示文摘Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future posing a major challenge to the healthcare system resulting in increased morbidity and mortality. It occurs as a result of interaction between both genetic and environmental factors in individuals with both type 1 and type 2 diabetes. Genetic susceptibility has been proposed as an important factor for the development and progression of diabetic nephropathy, and various research efforts are being executed worldwide to identify the susceptibility gene for diabetic nephropathy. Numerous single nucleotide polymorphisms have been found in various genes giving rise to various gene variants which have been found to play a major role in genetic susceptibility to diabetic nephropathy. The risk of developing diabetic nephropathy is increased several times by inheriting risk alleles at susceptibility loci of various genes like ACE, IL, TNF-α, COL4A1, e NOS, SOD2, APOE, GLUT, etc. The identification of these genetic variants at a biomarker level could thus, allow the detection of those individuals at high risk for diabetic nephropathy which could thus help in the treatment, diagnosis and early prevention of the disease. The present review discusses about the various gene variants found till date to be associated with diabetic nephropathy. | Saliha Rizvi Syed Tasleem Raza Farzana Mahdi | 2014 | World Journal of Diabetes2014，5，6： | 20 |
| 8 | Cancer cachexia,mechanism and treatment显示文摘It is estimated that half of all patients with cancer eventually develop a syndrome of cachexia, with anorexia and a progressive loss of adipose tissue and skeletal muscle mass. Cancer cachexia is characterized by systemic inflammation, negative protein and energy balance, and an involuntary loss of lean body mass. It is an insidious syndrome that not only has a dramatic impact on patient quality of life, but also is associated with poor responsesto chemotherapy and decreased survival. Cachexia is still largely an underestimated and untreated condition, despite the fact that multiple mechanisms are reported to be involved in its development, with a number of cytokines postulated to play a role in the etiology of the persistent catabolic state. Existing therapies for cachexia, including orexigenic appetite stimulants, focus on palliation of symptoms and reduction of the distress of patients and families rather than prolongation of life. Recent therapies for the cachectic syndrome involve a multidisciplinary approach. Combination therapy with diet modification and/or exercise has been added to novel pharmaceutical agents, such as Megestrol acetate, medroxyprogesterone, ghrelin, omega-3-fatty acid among others. These agents are reported to have improved survival rates as well as quality of life. In this review, we will discuss the emerging understanding of the mechanisms of cancer cachexia, the current treatment options including multidisciplinary combination therapies, as well an update on new and ongoing clinical trials. | Tomoyoshi Aoyagi Krista P Terracina Ali Raza Hisahiro Matsubara Kazuaki Takabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，4： | 20 |
| 9 | Crop photosynthetic response to light quality and light intensity显示文摘Under natural conditions, plants constantly encounter various biotic and abiotic factors, which can potentially restrict plant growth and development and even limit crop productivity. Among various abiotic factors affecting plant photosynthesis, light serves as an important factor that drives carbon metabolism in plants and supports life on earth. The two components of light(light quality and light intensity) greatly affect plant photosynthesis and other plant's morphological, physiological and biochemical parameters. The response of plants to different spectral radiations and intensities differs in various species and also depends on growing conditions. To date, much research has been conducted regarding how different spectral radiations of varying intensity can affect plant growth and development. This review is an effort to briefly summarize the available information on the effects of light components on various plant parameters such as stem and leaf morphology and anatomy, stomatal development, photosynthetic apparatus, pigment composition, reactive oxygen species(ROS) production, antioxidants, and hormone production. | Iram SHAFIQ Sajad HUSSAIN Muhammad Ali RAZA Nasir IQBAL Muhammad Ahsan ASGHAR Ali RAZA FAN Yuan-fang Maryam MUMTAZ Muhammad SHOAIB Muhammad ANSAR Abdul MANAF YANG Wen-yu YANG Feng | 2021 | Journal of Integrative Agriculture2021，20，1： | 16 |
| 10 | 四川地区玉米/大豆带状套作对大豆形态、叶绿素荧光特征及系统产量的影响显示文摘玉米/大豆带状套作可以充分利用光环境,提高单位土地面积物质产出。为探明玉米/大豆带状复合种植模式下不同空间配置对大豆冠层光环境、形态、产量及系统效益的影响,进而为大豆高产优质栽培提供依据,本研究选用半紧凑型(‘川单418’)和紧凑型(‘荣玉1210’)玉米品种与大豆带状套作,固定带宽为200cm,玉米采用宽窄行种植,玉米窄行距设置3个处理:20cm、40cm、60cm;并以单作大豆(SS)作为对照。分析透光率、形态、光合色素、荧光参数、生物量和系统产量的变化规律。结果表明:套作大豆冠层透光率、红光/远红光(R/FR)比值随玉米窄行距的增大而逐渐降低;套作下大豆茎粗、节数、茎干重和全叶干重均随玉米窄行距增大呈降低趋势,最大值出现在玉米窄行距20cm处理下;与单作大豆相比,两个玉米品种下大豆茎粗、节数、茎干重和全叶干重均显著降低,而第2节间长和主茎长显著升高。套作下大豆叶片光合色素含量随玉米窄行距的增大而逐渐降低,各行距处理及不同玉米品种下套作的叶片光合色素含量均低于单作大豆。大豆叶片荧光参数Fv/Fm、NPQ、Fq'Fm'和Fq'/Fv'随玉米窄行距的增大均呈先增大后减小的趋势,而Fo变化趋势与之相反。玉米收获后,大豆光环境得到改善并迅速恢复生长,套作大豆形态生理指标与单作差异减小,但由于前期玉米的遮荫,各套作处理间大豆产量差异仍显著。通过系统效益分析,在玉米窄行距40cm处理下,套作系统综合产量最高,两玉米品种下玉米、大豆产量平均分别为8559.52kg·hm^-2、1717.60kg·hm^-2,土地当量比平均达1.57。本试验中大豆与两个株型玉米套作,大豆形态生理指标差异影响不显著。因此,选择紧凑或半紧凑玉米品种,适度缩小玉米窄行距可以显著改善带状套作大豆的生长环境,提高其生物量和产量。 | 陈元凯 冯铃洋 Muhammad Ali Raza 范元芳 谌俊旭 雍太文 杨文钰 杨峰 | 2019 | 中国生态农业学报(中英文)2019，27，6： | 16 |
| 11 | Current treatment options for colon cancer peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis(PC),the dissemination of cancer cells throughout the lining of the abdominal cavity,is the second most common presentation of colon cancer distant metastasis.Despite remarkable advances in cytotoxic chemotherapy and targeted therapy for colon cancer over the last 15 years,it has been repeatedly shown that these therapies remain ineffective for colon cancer PC.Recently,there has been a rapid accumulation of reports that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy(CRS-HIPEC) prolongs the life of colon cancer PC patients.Here,we will review the clinical presentation,the mechanisms of disease progression,and current treatment options for colon cancer PC,with a focus on the benefits and limitations of CRSHIPEC. | Tomoyoshi Aoyagi Krista P Terracina Ali Raza Kazuaki Takabe | 2014 | World Journal of Gastroenterology2014，20，35： | 15 |
| 12 | Advances in the management of peritoneal mesothelioma显示文摘Malignant peritoneal mesothelioma(PM) is an infrequent disease which has historically been associated with a poor prognosis. Given its long latency period and non-specific symptomatology, a diagnosis of PM can be suggested by occupational exposure history, but ultimately relies heavily on imaging and diagnostic biopsy. Early treatment options including palliative operative debulking, intraperitoneal chemotherapy, and systemic chemotherapy have marginally improved the natural course of the disease with median survival being approximately one year. The advent of cytoreduction(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC) has dramatically improved survival outcomes with wide median survival estimates between 2.5 to 9 years; these studies however remain largely heterogeneous, with differing study populations, tumor biology, and specific treatment regimens. More recent investigations have explored extent of cytoreduction, repeated operative intervention, and choice of chemotherapy but have been unable to offer definitive conclusions. CRS and HIPEC remain morbid procedures with complication rates ranging between 30% to 46% in larger series. Ac-cordingly, an increasing interest in identifying molecular targets and developing targeted therapies is emerging. Among such novel targets is sphingosine kinase 1(SphK1) which regulates the production of sphingosine-1-phosphate, a biologically active lipid implicated in various cancers including malignant mesothelioma. The known action of specific SphK inhibitors may warrant further exploration in peritoneal disease. | Ali Raza Wei-Ching Huang Kazuaki Takabe | 2014 | World Journal of Gastroenterology2014，20，33： | 15 |
| 13 | 氮磷配施对玉米-大豆套作模式下种间作用、玉米产量及干物质积累与转运的影响显示文摘以盆栽和田间小区试验结合的方法,通过设置根系分隔与不分隔方式及不同供氮(0、120、180、240kg/hm^2,记为N_0、N_(120)、N_(180)、N_(240))、供磷水平(0、35、70、105kg/hm2,记为P_0、P_(35)、P_(70)、P_(105)),探究在玉米-大豆套作模式下氮磷配施对种间作用、玉米产量及干物质积累与转运的影响。结果表明,1)氮磷互作效应对带状套作系统的种间促进作用显著,配施可缓解玉米与大豆的种间竞争作用,提高套作系统土地当量比率、种间竞争力和营养竞争比率,促进玉米对氮、磷素的吸收,表现出显著的套作产量优势和资源利用优势(LER>1),且优势效应高于单施氮、磷肥。2)氮磷互作对玉米各生育期干物质积累量的影响呈峰形变化趋势,中氮中磷(N_(180)P_(70))处理可显著降低花前干物质的积累量,增加成熟期干物质积累总量,促进花后干物质积累向籽粒转运,提高玉米收获指数。3)种间作用和氮磷互作可显著影响玉米产量,提高套作玉米有效穗和穗粒数,两种植模式中无论施肥与否,在套作条件下玉米的产量均高于净作,且在N_(180)P_(70)处理时玉米产量达到最大值,套作较净作增产幅度达1.65%~20.43%。本研究结果表明,套作模式下玉米氮磷配施以施氮180kg/hm^2、施磷70kg/hm^2时,种间促进作用显著,可改善其穗部性状,有利于成熟期干物质的积累和向籽粒的转运,最终获得较高的产量。 | 曾瑾汐 文熙宸 Muhammad Ali Raza 陈国鹏 陈诚 彭霄 马艳玮 李丽 官思成 杨文钰 王小春 | 2017 | 草业学报2017，26，7： | 11 |
| 14 | 氮肥及硝化抑制剂配合施用对石灰性土壤二氧化碳释放的影响显示文摘为研究施用氮肥对同时含有有机碳及无机碳石灰性土壤碳释放的影响,在陕西杨凌进行田间试验,比较了不同施氮量(0、160、220 kg·hm^(-2))及其与硝化抑制剂(DCD)配合(N160、N220及N160+DCD、N220+DCD)对土壤pH值、矿质态氮含量和二氧化碳(CO_2)释放量的影响。结果表明:施用氮肥显著降低了耕层土壤pH;配施DCD后土壤pH降低幅度小于未加DCD处理;加入DCD使氮肥的硝化过程推迟了约20 d;未加DCD处理的土壤CO_2释放量随施氮量增加而增加,试验结束时(施肥37 d后)土壤CO_2累积释放量最高达到167.1 g·m^(-2)。与N0处理相比,N160和N220处理的土壤CO_2累积释放量显著增加,增幅分别为20.9%和25.7%;N160+DCD和N220+DCD处理显著降低了土壤CO_2累积释放量,比对应相同施氮量处理分别降低了13.5%和11.0%。上述结果说明施用氮肥会同时影响石灰性土壤有机碳及无机碳的释放,施用氮肥引起的土壤无机碳的释放值得关注。 | 李雪松 Sajjad Raza 刘占军 陈竹君 周建斌 | 2017 | 农业环境科学学报2017，36，8： | 11 |
| 15 | 福美双诱导的肉鸡胫骨软骨发育不良软骨细胞凋亡显示文摘为研究肉鸡胫骨软骨发育不良(TD)软骨细胞的凋亡分布及凋亡相关基因的表达水平,将80羽1日龄健康AA肉鸡基础日粮饲养1周后,随机分为对照组和处理组,处理组饲喂添加100mg·kg-1福美双的日粮,采用HE染色和TUNEL法分别对肉鸡胫骨生长板软骨细胞的形态学和凋亡情况进行观察,同时采用Real-time PCR方法和免疫组化技术分别对软骨细胞中凋亡相关基因的mRNA转录水平及蛋白质表达水平进行检测。结果显示,福美双诱发TD后第1、2、4和6天,肉鸡生长板软骨栓形成逐渐增大,异常软骨细胞增加,TD病变区软骨细胞,尤其是肥大区软骨细胞凋亡程度明显增加。Real-time PCR检测结果显示,与对照组比较,TD生长板促凋亡基因Bax在试验第1、2、4和6天表达量极显著上调(P<0.01);Caspase-3在第1、2和4天表达量极显著增加(P<0.01);抗凋亡基因BAG-1表达下调,在试验第1和2天差异极显著(P<0.01)。免疫组化结果显示,第1和4天处理组Bax的蛋白表达量明显高于对照组。本研究提示肉鸡TD生长板软骨细胞凋亡与促凋亡基因的表达增强和抗凋亡基因的表达下降有关。 | 张宁 李欣 宁官保 张鼎 Ali Raza Jahejo 李宏全 马海利 郝卫芳 高文伟 赵宇军 高诗敏 李桂兰 李建慧 闫芳 高荣琨 田文霞 | 2017 | 畜牧兽医学报2017，48，12： | 9 |
| 16 | Somatic embryogenesis in wild relatives of cotton (Gossypium Spp.)显示文摘Wild cotton species can contribute a valuable gene pool for agronomically desirable cultivated tetraploid cultivars. In order to exploit diploid cotton a regeneration system is required to achieve transformation based goals. The present studies aimed at optimizing the conditions for regeneration of local varieties as well as wild species of cotton. Different callus induction media were tested with varying concentrations of hormones in which sucrose was used as nutritional source. Different explants (hypo-cotyls, cotyledon, root) were used to check the regeneration of both local cotton plants and wild relatives using T & G medium, BAP medium, CIM medium, EMMS medium, and cell suspension medium. Different stages of embryogenicity such as early torpedo stage, late torpedo stage, heart stage, globular stage and cotyledonary stage were observed in wild relatives of cotton. The results of this study pave the way for establishing future transformation methods. | RAO Abdul Qayyum HUSSAIN S. Sarfraz SHAHZAD M. Saqib BOKHARI S. Yassir Abbas RAZA M. Hashim RAKHA Allah MAJEED A. SHAHID A. Ali SALEEM Zafar HUSNAIN Tayyab RIAZUDDIN S. | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，4： | 9 |
| 17 | Risk factors for colonoscopic perforation: A population-based study of 80118 cases显示文摘AIM: To assess the incidence and risk factors associated with colonic perforation due to colonoscopy. METHODS: This was a retrospective cross-sectional study. Patients were retrospectively eligible for inclusion if they were 18 years and older and had an inpatient or outpatient colonoscopy procedure code in any facility within the Geisinger Health System during the period from January 1, 2002 to August 25, 2010. Data are presented as median and inter-quartile range, for continuous variables, and as frequency and percentage for categorical variables. Baseline comparisons across those with and without a perforation were made using the two-sample t -test and Pearson's χ2 test, as appropriate.RESULTS: A total of 50 perforations were diagnosed out of 80118 colonoscopies, which corresponded to an incidence of 0.06% (95%CI: 0.05-0.08) or a rate of 6.2 per 10000 colonoscopies. All possible risk factors associated with colonic perforation with a P -value < 0.1 were checked for inclusion in a multivariable logbinomial regression model predicting 7-d colonic perforation. The final model resulted in the following risk factors which were significantly associated with risk of colonic perforation: age, gender, body mass index, albumin level, intensive care unit (ICU) patients, inpatient setting, and abdominal pain and Crohn's disease as indications for colonoscopy. CONCLUSION: The cumulative 7 d incidence of colonic perforation in this cohort was 0.06%. Advanced age and female gender were significantly more likely to have perforation. Increasing albumin and BMI resulted in decreased risk of colonic perforation. Having a colonoscopy indication of abdominal pain or Crohn's disease resulted in a higher risk of colonic perforation. Colonoscopies performed in inpatients and particularly the ICU setting had substantially greater odds of perforation. Biopsy and polypectomy did not increase the risk of perforation and only three perforations occurred with screening colonoscopy. | Uzair Hamdani Raza Naeem Fyeza Haider Pardeep Bansal Michael Komar David L Diehl H Lester Kirchner | 2013 | World Journal of Gastroenterology2013，19，23： | 9 |
| 18 | 高发心脏性猝死的3型长QT综合征一家系报道显示文摘目的 采用基因检测和电生理功能分析诊断长QT综合征(LQTS)患者,发现有潜在患病风险的家系成员,以提供临床评估与适当的治疗.方法 采集和分析1例LQTS患儿及所在家系成员的临床资料.同时选择200例具有相同种族背景的健康个体作为正常对照.聚合酶链式反应(PCR)扩增LQTS先证者候选基因KCNQ1、KCNH2和SCN5A外显子及附近上下游序列,直接测序并进行分析.如发现突变,进一步采用全细胞膜片钳技术对该突变进行电生理功能分析,并对其家系成员进行特定突变基因筛查,寻找基因变异及评估其发生心脏性猝死风险.结果 先证者12导联常规心电图初步诊断为LQTS.临床上给予美托洛尔(25 mg、2次/d)治疗,患者服药第3天于午饭时猝死.基因检测发现先证者SCN5A基因上存在一个杂合子错义突变(V411M),在正常对照组该位点未发现基因突变.与野生型相比,V411M突变型钠通道表现为峰值钠电流[(230.8±27.6) pA/pF比(101.2±10.9)pA/pF,n=10,P<0.01]及晚钠电流[(156.6±13.6) pA/pF比(95.9±7.9) pA/pF,n=12,P<0.01]增加.测试脉冲电压在-50 mV时,V411M突变型的钠通道激活数目明显多于野生型(85.0%±7.4%比41.5%±2.6%,P<0.01).V411M突变型稳态激活曲线左移,而稳态失活曲线无明显变化.另外,其他家系成员进行SCN5A基因检测发现,先证者母亲、外祖母为无症状突变携带者,给予适当临床评估及长期随访.先证者的同卵双生姐姐及姨妈死于婴儿猝死综合征.结论 首次在国人LQTS患者SCN5A基因上报道一个杂合子错义突变(V411M).V411 M突变导致钠离子通道蛋白的“功能增强”效应,构成3型LQTS的发病基础.基因检测和电生理功能分析有助于明确LQTS患者及其家系成员的疾病诊断,并提供重要临床评估与治疗,预防心脏性猝死的发生. | 周慧 Li Zhang Ali Raza Ghani 朱文根 周琼琼 申阳 谢金燕 曹青 万蓉 胡金柱 洪葵 | 2015 | 中华心血管病杂志2015，43，12： | 8 |
| 19 | 沼液替代化肥对甜瓜产量品质及养分吸收的影响显示文摘以'绿宝石'薄皮甜瓜为试材,采用田间小区随机区组试验,设置5个处理(CK:不施肥,CF:常规施肥,FR:化肥减量,BS:沼液替代,BR:沼液减量),研究了集约化养猪场粪肥和废水发酵后的沼液通过水肥一体化管道施用替代化肥对日光温室栽培甜瓜产量、品质及养分吸收的影响。结果表明:1)不同处理间甜瓜根、茎、叶、果实的干物质量和养分含量及养分携出量均无显著差异,甜瓜温室栽培下每形成1 000 kg经济产量对N、P2O5、K2O吸收量分别为4.16~4.68、1.04~1.36、7.07~7.85 kg,N、P2O5、K2O需求比例平均为1∶0.30∶1.72。2)不同处理间甜瓜单果质量和产量均无显著差异;BS、BR处理甜瓜可溶性总糖含量、可溶性固形物含量、糖酸比较CF处理显著提高。3)BS、BR和FR处理节本增收效果显著,较CF处理分别增效26.77%、8.49%和3.37%;BR和FR处理N、P、K养分利用率较CF处理分别提高12.47%、9.84%、15.26%和11.10%、9.62%、41.47%。综上,沼液水肥一体化可以完全替代化肥追施,实现沼液资源化利用。 | 高旭 孔祥俊 郭雨浓 李佳聪 SAJJAD Raza 陈竹君 | 2019 | 北方园艺2019，，14： | 8 |
| 20 | Different faces of gastroparesis显示文摘AIM:To test the hypothesis that pain and affect rather than impaired emptying determine symptom severity in patients with gastroparesis.METHODS:Adult patients with documented gastroparesis were enrolled prospectively in a single center and asked to complete the Gastroparesis Cardinal Symptom Index(GCSI),Hospital Anxiety and Depression Scale(HADS),the Short Form 12(SF-12) as quality of life index,rate pain severity and answer 10 open-ended questions.RESULTS:A total of 55 patients(44 women) participated.Idiopathic(n=29) or diabetic(n=11) gastroparesis and connective tissue disease(n=8) were the most common underlying causes.Antiemetics(n=30) and prokinetics(n = 32) were most often prescribed.Seventeen patients used opioids on a daily basis.Nausea and/or vomiting(n=28),pain(n=24) and bloating(n=14) were most commonly listed as dominant symptoms.Patients subjectively attributed symptom improvement to nutritional and dietary therapy(n=11),prokinetics(n=11),antiemetics(n=10) or analgesic agents(n=3).In univariate analyses,the physical subscore of the SF-12 and HADS,but not gastric emptying delay or symptom duration signifi cantly correlated with disease severity as measured by the GCSI.In multivariate analyses,the combination of vomiting,bloating and depression best predicted the overall impact on quality of life.CONCLUSION:The study confi rms the importance of pain and affect in gastroparesis,which requires novel approaches to improve more effectively the quality of life in patients with this disorder. | Klaus Bielefeldt Naeem Raza Susan L Zickmund | 2009 | World Journal of Gastroenterology2009，15，48： | 8 |
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