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| 1 | Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review显示文摘Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease(IBD).Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels,long standing disease,and frequent steroid exposures;as a result,it is well established that vitamin D supplementation in this population is important.There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD.The active form of vitamin D,1,25(OH)D3,acts on T cells to promote T helper(Th)2/regulatory T responses over Th1/Th17 responses;suppresses dendritic cell inflammatory activity;induces antibacterial activity;and regulates cytokine production in favor of an antiinflammatory response.Murine and human IBD studies support a therapeutic role of vitamin D in IBD.Risk factors for vitamin D deficiency in this population include decreased sunlight exposure,disease duration,smoking,and genetics.Vitamin D normalization is associated with reduced risk of relapse,reduced risk of IBD-related surgeries,and improvement in quality of life.Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes.However,further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects,and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission,as well as maintaining this improvement in patients’disease states. | Krista M Reich Richard N Fedorak Karen Madsen Karen I Kroeker | 2014 | World Journal of Gastroenterology2014，20，17： | 34 |
| 2 | AlphaV - and betalintegrin suSunits are commonly expressed in malignant cffusions from ovarian carcinoma patients 显示文摘 | Davidson B Goldserg I Reich R | 2003 | Gynecol Oncol2003，90，： | 1 |
| 3 | The worldwide leaf economics spectrum显示文摘 | WRIGHT I J REICH P B WESTOB Y M | 2004 | Nature2004，428，： | 1 |
| 4 | The world- wide leaf economies spectrum显示文摘 | Wright I J Reich P B Westoby M | 2004 | Nature2004，428，： | 1 |
| 5 | Evidence of a general 2/3-power law of scaling leaf nitrogen to phosphorus among major plant groups and biomes 显示文摘 | REICH P B OLEKSYN J WRIGHT I J | 2010 | Proc R Soc B2010，277，： | 1 |
| 6 | Strategy shifts in leaf physiology, structure and nutrient content between species of high- and low-rainfall and high- and low-nutrient habitats 显示文摘 | WRIGHT I J REICH P B WESTOBY M | 2001 | Functional Ecology2001，15，4： | 1 |
| 7 | The worldwide leaf economics spectrum 显示文摘 | Wright I J Reich P B Westoby M | 2004 | Nature2004，428，： | 1 |
| 8 | Convergence towards higher leaf mass per area in dry and nutrient-poor habitats has different consequences for leaf life span 显示文摘 | WRIGHT I J WESTOBY M REICH P B | 2002 | Journal of Ecology2002，90，3： | 1 |
| 9 | The worldwide leaf economics spectrum 显示文摘 | WRIGHT I J REICH P B WESTOBY M | 2004 | Nature2004，428，： | 1 |
| 10 | Assessing the generality of global leaf trait relationships 显示文摘 | Wright I J Reich P B Cornelissen J H C | 2005 | New Phytologist2005，166，： | 1 |
| 11 | An iterative method for solving a class of nonlinear operator equations in Banach spaces显示文摘 | ALBER Y I REICH S | 1999 | Panamer Math1999，4，： | 1 |
| 12 | The worldwide leaf economics spectrum显示文摘 | WRIGHT I J REICH P B WESTOBY M | 2004 | Nature2004，428，： | 1 |
| 13 | Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital 显示文摘 | Cunningham I Gee TS Reich LM | 1989 | Blood1989，73，5： | 1 |
| 14 | Measuring the Linkage between Business and IT Objectives显示文摘 | Reich B Benbasat I | | 0，，01： | 1 |
| 15 | Morphology,perfectionand growth of natural pyrite whiskers and thin platelets显示文摘 | Bonev I K Reiche M Marinov M | 1985 | Physics and Chemistry of Minerals1985，12，4： | 1 |
| 16 | The leaf economics spectrum worldwide 显示文摘 | Wright I J Reich P B Westoby M | 2004 | Nature2004，428，： | 1 |
| 17 | Strategy shifts in leaf physiology, struclure and nutrient content between species of high-and low-rainfall and high-and low-nutrient habitats 显示文摘 | Wright I J Reich P B Westoby M | 2001 | Functional Ecology2001，15，4： | 1 |
| 18 | Building effective public-private partnerships: Experiences and lessons from the African comprehensive HIV/AIDS partnerships显示文摘 | Ramiah I Reich M | 2006 | Social Science and Medicine2006，63，2： | 1 |
| 19 | Measuring the Linkage between Business and Information Technology Objectives显示文摘 | REICH B H BENBASAT I | 1996 | MIS Quarterly1996，20，1： | 1 |
| 20 | Critical evaluation of two primers commonly used for amplification of bacterial 16S rRNA genes显示文摘 | Frank J A Reich C I Shanna S | 2008 | Appl Environ Microbiol2008，74，8： | 1 |
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