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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Purification and properties of two endochitosanases from Mucor rouxii implicated in its cell wall degradation 显示文摘 | Alfonso C Martinez M J Reyes F | 1992 | Fems Microbiology Letters1992，95，23： | 1 |
| 3 | The envelope glycoprotein from tick-borne encephalitis virus at 2A resolution显示文摘 | Rey F A Heinz F X Mandl C | | 0，，： | 1 |
| 4 | Steady state segregation and heat flow in ESR 显示文摘 | Ridder S D Reyes F C Chakravorty S | 1978 | Metall Trans: B1978，9，4： | 1 |
| 5 | Kashin - Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status显示文摘 | Moreno - Reyes R Suetens C Mathieu F | 1998 | New England Journal of Medicine1998，339，16： | 1 |
| 6 | Genetic parameters for growth and reproductive traits of Can- chim breed 显示文摘 | Borba L H F Rey F S B da Silva L O C | 2011 | Pesquisa Agropecu Bras2011，46，11： | 1 |
| 7 | Prevention of malignant seeding after invasive diagnostic procedures in patients with pleural mesothelioma显示文摘 | Boutin C Rey F Viallat JR | 1995 | Chest1995，108，： | 1 |
| 8 | Study of the prognostic value of DNA ploidy and proliferation index (Ki 67) in renal cell carcinoma with venous thrombus显示文摘 | Rey D Pfister C Gobet F | 2003 | Prog Urol2003，13，6： | 1 |
| 9 | The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution显示文摘 | Rey F A Heinz F X Mandl C | 1995 | Nature1995，375，6529： | 1 |
| 10 | The GATA family of transcription factors in Arabidopsis and rice显示文摘 | Reyes J C Muro-Pastor M I Florencio F J | 2004 | Plant Physiol2004，134，4： | 1 |
| 11 | Mechanical complications during central venous cannulations in pediatric patients显示文摘 | Rey C Alvarez F De La Rua V | 2009 | Intensive Care Med2009，35，8： | 1 |
| 12 | Human bocavirus infections in Spanish 0-14 year-old: clinical and epidemiological characteristics of an emerging respiratory virus 显示文摘 | Garcfa-Garcia ML Calvo Rey C Pozo Sanehez F | 2007 | An Pediatr (Bare)2007，67，： | 1 |
| 13 | The GATA family of transcription factors in Arabidopsis and rice显示文摘 | Reyes J C Muro-Pastor M I Florencio F J | 2004 | PlantPhysiology2004，134，4： | 1 |
| 14 | The GATA family of transeription factors in Arabidopsis and rice显示文摘 | Reyes J C Pastor M I Floreneio F J | 2004 | Plant Physiol2004，134，4： | 1 |
| 15 | Redirection of metabolismfor biological hydrogen production显示文摘 | Rey F E Heiniger E K Harwood C S | 2007 | Appl Environ Microbiol2007，73，5： | 1 |
| 16 | The envelope glycopro- tein from tick - borne encephalitis virus at 2 It resolution 显示文摘 | REY F A HEINZ F X MANDL C W | 1995 | Na- ture1995，375，： | 1 |
| 17 | Tumor necrosis factor-alpha inhibits leydig cell steroidogenesis througha decrease in steroidogenic acute regulatory protein expression显示文摘 | Mauduit C Gasnier F Rey C | 1998 | Endocrinol1998，139，6： | 1 |
| 18 | Isolation of a T-lymphotropic retrovirus from a patient atrisk for acquired immune deficiency syndrome (AIDS) 显示文摘 | BARRé-SINOUSSI F CHERMANN J C REY F | 1983 | Science1983，220，4599： | 1 |
| 19 | Endogenous polyamine concentration in juvenile, adult and in vitro reinvigorated hazel显示文摘 | Rey M Tiburcio A F Diaz-Sala C | 1994 | Tree Physiol1994，14，： | 1 |
| 20 | Experience in one centre using the buttoned device for occlusion of atrial septal defect: comparison with the Amplatzer septal occluder 显示文摘 | Rey C Francart C | 2000 | Cardiol Young2000，10，5： | 1 |
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