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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Inflammatory bowel disease in pediatric and adolescent patients:A biomolecular and histopathological review显示文摘Crohn’s disease(CD)and ulcerative colitis(UC)are the two main forms of inflammatory bowel disease(IBD)with both overlapping and distinct clinical,pathological and biomolecular features.It has been suggested that pediatric IBD is a distinct disease entity,with probably different disease subtypes.The aim of this study is to review and summarize the evolution of the current concept of pediatric IBD.The results of this review reinforce the idea that pediatric CD and UC may be further classified in various clinicopathologic entities.For clinicians and pathologists convenience,practical algorithms for the distinction of the various subphenotypes of pediatric IBD are also provided. | Luciana Rigoli Rosario Alberto Caruso | 2014 | World Journal of Gastroenterology2014，20，30： | 5 |
| 3 | Phagocytosis(cannibalism) of apoptotic neutrophils by tumor cells in gastric micropapillary carcinomas显示文摘AIM:To identify those with a micropapillary pattern,ascertain relative frequency and document clinicopathological characteristics by reviewing gastric carcinomas.METHODS:One hundred and fifty-one patients diagnosed with gastric cancer who underwent gastrectomy were retrospectively studied and the presence of a regional invasive micropapillary component was evaluated by light microscopy.All available hematoxylin-eosin(HE)-stained slides were histologically reviewed and 5 tumors were selected as putative micropapillary carcinoma when cancer cell clusters without a vascular core within empty lymphatic-like space comprised at least5%of the tumor.Tumor tissues from these 5 invasive gastric carcinomas were immunostained using an antimucin 1(MUC1)antibody(clone MA695)to detect the characteristic inside-out pattern and with D2-40antibody to determine the presence of intratumoral lymph vessels.Detection of intraepithelial neutrophil apoptosis was evaluated in consecutive histological tissue sections by three independent methods,namely light microscopy with HE staining,the conventional terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end-labeling(TUNEL)method and immunohistochemistry for activated caspase-3(clone C92-605).RESULTS:Among 151 gastric cancers resected for cure,5(3.3%)were adenocarcinomas with a micropapillary component.Four of the patients died of disease from 6 to 23 mo and one patient was alive with metastases at 9 mo.All patients had advanced-stage cancer(≥p T2)and lymph node metastasis.Positive MUC1 immunostaining on the stroma-facing surface(inside-out pattern)of the carcinomatous cluster cells,together with negative immunostaining for D2-40 in the cells limiting lymphatic-like spaces,confirmed the true micropapillary pattern in these gastric neoplasms.In all five cases,several micropapillae were infiltrated by neutrophils.HE staining,TUNEL assay and immunostaining for caspase-3 demonstrated apoptoticneutrophils within cytoplasmic vacuoles of tumor cells.These data suggest phagocytosis(cannibalism)of apoptotic neutrophils by micropapillary tumor cells.Tumor cell cannibalism is usually found in aggressive tumors with anaplastic morphology.Our data extend these observations to gastric micropapillary carcinoma:a tumor histotype analogously characterized by aggressive behavior and poor prognosis.The results are of interest because they raise the intriguing possibility that neutrophil cannibalism by tumor cells may be one of the mechanisms favoring tumor growth in gastric micropapillary carcinomas.CONCLUSION:This is the first study showing phagocytosis(cannibalism)of apoptotic neutrophils by tumor cells in gastric micropapillary carcinomas. | Valeria Barresi Giovanni Branca Antonio Ieni Luciana Rigoli Giovanni Tuccari Rosario Alberto Caruso | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 4 | Mitochondrial DNA alterations in the progression of gastric carcinomas:Unexplored issues and future research needs显示文摘Gastric cancer is the second most frequent cause of cancer death worldwide.Patients infected with Helicobacter pylori(H.pylori)are at increased risk of gastric cancer.H.pylori induces genomic instability in both nuclear and mitochondrial(mt)DNA of gastric epithelial cells.Changes in mt DNA represent an early event during gastric tumorigenesis,and thus may serve as potential biomarkers for early detection and prognosis in gastric carcinoma.This review article summarizes the mt DNA mutations that have been reported in gastric carcinomas and their precancerous conditions.Unexplored research topics,such as the role of mt DNA alterations in an alternative pathway of gastric carcinogenesis,are identified and directions for future research are suggested. | Luciana Rigoli Rosario Alberto Caruso | 2014 | World Journal of Gastroenterology2014，20，43： | 2 |
| 5 | Be- yond benzyl grignards: facile generation of benzyl car- banions from styrenes 显示文摘 | GRIGG R D RIGOLI J W HOVELN R V | 2012 | Chem Eur J2012，18，30： | 1 |
| 6 | Depressive symptomatology in child and adolescent twins with attention-deficit hyperactivity disorder and/or developmental coordination disorder显示文摘 | Piek JP Rigoli D Pearsall-Jones JG | 2007 | Twin Res Hum Genet2007，10，4： | 1 |
| 7 | TLR2 and TLR4 gene polymorphisms and atopic dermatitis in Italian children: a muhicenter study 显示文摘 | Salpietro C Rigoli L Miraglia DGM | 2011 | Int J Immunopathol Phar- macol2011，24，4： | 1 |
| 8 | HER-2 Status in Premalignant,Early,and Advanced Neoplastic Lesions of the Stomach显示文摘 | Ieni A Barresi V Rigoli L | 2015 | Disease Markers2015，2015，23： | 1 |
| 9 | On conformal minimal immersions of S2 into CPn显示文摘 | Bohon J Jensen G R Rigoli M | 1988 | Math Ann1988，279，： | 1 |
| 10 | Prognostic and biological significance of cytokeratin 19 in pancreatic endocrine tumours 显示文摘 | La Rosa S Rigoli E Uccella S | 2007 | Histopathology2007，50，5： | 1 |
| 11 | TLR2 and TLR4 gene polymorphisms and atopic dermatitis in Italian children: a multicenter study 显示文摘 | Salpietro C Rigoli L Ciprandi G | 2011 | Int J Immunopathol Pharmacol2011，24，4： | 1 |
| 12 | On Conformal Minimal Immersions of S2 into CPn显示文摘 | Bolton J Jensen GR Rigoli M | 1988 | Math Ann1988，279，： | 1 |
| 13 | Motor coordination and psy- chosocial correlates in a normative adolescent sample显示文摘 | RIGOLI D JAN P P ROBERT K | 2012 | Pedi- atrics2012，129，： | 1 |
| 14 | Gene-environment interac- tion in childhood asthma 显示文摘 | Rigoli L Briuglia S Caimmi S | 2011 | Int J Immunopathol Pharmacol2011，24，4： | 1 |
| 15 | Angiotensin-converting enzyme and angiotensin type 2 receptor gene genotype distributions in Italian children with congenital uropathies 显示文摘 | Rigoli L Chimenz R di Bella C | 2004 | Pediatr Res2004，56，6： | 1 |
| 16 | Fair Valuation Issues and the Subprime Mortgage Debacle: Could Generally Accepted Accounting Principles Underlying the Historical Cost Method Have Prevented the Crisis?显示文摘 | Constance Crawford Corinne Crawford Raymond Rigoli | 2011 | Journal of Modern Accounting and Auditing2011，7，11： | 1 |
| 17 | Wolfram syndrome 1 and Wolfram 2显示文摘 | Rigoli L Di Bella C | 2012 | Curr Opin Pediatr2012，24，： | 1 |
| 18 | Attention deficit hyperactivity disorder and developmental coordination disorder: two separate disorders or do they share a common etiology显示文摘 | Goulardins J B Rigoli D Licari M | 2015 | Behav Brain Res2015，292，： | 1 |
| 19 | CYP2E1 overexpression alters hepatocyte death form menadione and fatty acids by activation of ERK1/2 signaling 显示文摘 | J M Schattenberg Y Wang R M Rigoli | 2004 | Hepatology2004，39，2： | 1 |
| 20 | Fibrocartilaginous embolism of the spinal cord:a clinical and pathogenetic reconsideration显示文摘 | Tosi L Rigoli G Beltramello A | 1996 | Neurol Neurosurg Psychiatry1996，60，： | 1 |
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