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| 1 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 2 | Pharmacological properties of Anagallis arvensis L. (“scarlet pimpernel”) and Anagallis foemina Mill. (“blue pimpernel”) traditionally used as wound healing remedies in Navarra (Spain)显示文摘 | Víctor López Anna K. J?ger Silvia Akerreta Rita Yolanda Cavero Maria Isabel Calvo | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 3 | Psychological antecedents of institution-based consumer trust in e-retailing显示文摘 | Rita W Henriette L | 2004 | Information and Management2004，42，1： | 1 |
| 4 | Condensation and decondensation of DNA by cationic surfactant, spermine or cationic surfactant cyclo dextrin mixtures:macroscopic phase behavior, aggregate properties and dissolulion mechanisms显示文摘 | Jonas C Dan L Rita S | 2012 | Langmuir2012，28，21： | 1 |
| 5 | Comparison of the Etest and the NCCLS-approved agar dilution method to detect metronidazole and clarithromycin resistant Helicobacter pylori显示文摘 | Michael S Osato Rita Reddy Siddartha G Reddy Rebecca L Penland David Y Graham | 2001 | International Journal of Antimicrobial Agents2001，，1： | 1 |
| 6 | Elevated levels of C - reac- tive protein at discharge in patients with unstable angina predict recurrent instability显示文摘 | Luigi MB Giovanna L Rita LG | 1999 | Circulation1999，99，： | 1 |
| 7 | Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction显示文摘 | Lars Gullestad Stein ?rn Kenneth Dickstein Christian Eek Thor Edvardsen Svend Aakhus Erik T. Askevold Annika Michelsen Bj?rn Bendz Rita Sk?rdal Hans-J?rgen Smith Arne Yndestad Thor Ueland P?l Aukrust | 2012 | International Journal of Cardiology2012，，： | 1 |
| 8 | Treatment of uterine myoma with5 or 10 mg mifepristone daily during 6 months,post-treatment evolution over 12 months:double-blind randomised clinical trial显示文摘 | Josep L Carbonell E Rita A | 2012 | Eur J Obstet Gynecol Reprod Biol2012，161，2： | 1 |
| 9 | NT-proBNP predicts myocardial recovery after non-ST-elevation acute coronary syndrome显示文摘 | Kaspar Broch Christian Eek Ragnhild Wergeland Thor Ueland Rita Sk? rdal P? l Aukrust Helge Skulstad Lars Gullestad | 2012 | Scandinavian Cardiovascular Journal2012，，2： | 1 |
| 10 | Almeida e Silva, Response surface methodology for xylital production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rita C L B Rodrigues Maria das Gracas A Felipe Joao B | 2003 | Process Biochemistry2003，38，： | 1 |
| 11 | Antimicrobial and healing activity of Kefir and Kefiranextract 显示文摘 | Kamila L R Lucelia Rita G C Jose Carlos T C | 2005 | International Journal of Antimicrobial Agents2005，25，： | 1 |
| 12 | Physical activity and reduced occurrence of non-insulin-dependent diabetes meilitus显示文摘 | Susan P H David R R Rita W L | 1991 | N Engl J Med1991，325，3： | 1 |
| 13 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 14 | Elevated levels of creactive protein at discharge in patients with unstable angina predict recurrent instability显示文摘 | Luigi M Giovanna L Rita L | 1998 | Clin Invest Rep1998，11，： | 1 |
| 15 | In Vitro Antioxidant and Anti-rhizopus Activities of Lamiaceae Herbal Extracts显示文摘 | Víctor López Silvia Akerreta Esther Casanova Jose María García-Mina Rita Yolanda Cavero María Isabel Calvo | 2007 | Plant Foods for Human Nutrition2007，，4： | 1 |
| 16 | Polyhydroxylated tri-terpenes from Eriobotrya japonica显示文摘 | Zhou Z L Rita A Vincenzo D F | 1990 | Planta Med1990，56，3： | 1 |
| 17 | Constructing sustainable vertical cities:strategies to enhance closer cooperation between ASEAN contractors on pollution problem under the lens of economic game theories-cost benefit analysis and dynamic Markov chain theories显示文摘 | Rita Y Man L | 2010 | Athletes Now2010，6，5： | 1 |
| 18 | Novel 3D scaffolds of chitosan-PLLA blends for tissue engineering applications:Preparation and characterization显示文摘 | Ana Rita C.Duarte Joao F Mano Rui L Reis | | 0，，： | 1 |
| 19 | Impact of Positive Intraabdominal Lavage Cytology on the Long-term Prognosis of Colorectal Cancer Patients显示文摘 | Rita Temesi László Sikorszki János Bezsilla ákos Botos Judit Kovács Tibor Tihanyi | 2012 | World Journal of Surgery2012，，11： | 1 |
| 20 | Artichoke juice improves endothelial function in hyperlipemia显示文摘 | Graziana L Simona M Rita L | 2004 | Life Sci2004，76，： | 1 |
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