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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 3 | 重型颅脑损伤的早期治疗(英文)显示文摘Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the pathophysiology of this injury,this has not yet led to substantial improvements in outcome. In this report,we address present knowledge and its limitations,research innovations,and clinical implications. Improved outcomes for patients with severe traumat- ic brain injury could result from progress in pharmacological and other treatments,neural repair and regeneration,optimisation of surgical indications and techniques,and combination and individually targeted treatments. Expanded classification of traumatic brain injury and in- novations in research design will underpin these advances. We are optimistic that further gains in outcome for patients with severe traumat- ic brain injury will be achieved in the next decade. | Rosenfeld JV Maas AI Bragge P Morganti-Kossmann MC Manley GT Gruen RL | 2012 | 中华神经外科疾病研究杂志2012，11，6： | 2 |
| 4 | Flt3 ligand enhances the immunogenicity of a gag-based HIV-1 vaccine 显示文摘 | Pisarev VM Parajuli P Mosley RL | 2000 | Int J Immunopharmacol2000，22，11： | 2 |
| 5 | 老年高血压患者服用别嘌呤醇后血压的变化显示文摘尿酸可降低青少年血压,表明其在高血压发生发展的病理生理过程中可能起到直接的作用。但是其在老年人高血压中是否扮演同样的角色尚不清楚。该研究通过分析英国临床实践研究数据库的资料,以确定服用别嘌呤醇后血压的改变。方法:纳入〉65岁的使用别嘌呤醇治疗、且有治疗前和治疗时血压读数记录的高血压患者。同时纳入具有可比性的人群作为对照。 | 刘莉 叶鹏 Beattie CJ Fulton RL Higgins P Padmanabhan S McCallum L Walters MR Dominiczak AF Touyz RM Dawson J | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 6 | Completion of the primary structure of the human type Ⅳ collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16显示文摘 | EDDY RL FAN YS | 1990 | Genomics1990，6，： | 1 |
| 7 | Increased ventral striatal monoaminergic innervation in Tourette syndrome显示文摘 | Albin RL Koeppe RA Bohnen NI Nichols TE Meyer P Wernette K | 2003 | Neurology2003，61，3： | 1 |
| 8 | A randomized trial of therapies for type 2 diabetes and coronary artery disease显示文摘 | BARI 2D Study Group Frye RL August P | | New England Journal of Medicine0，，： | 1 |
| 9 | MIC-1 serum level and genotype : associations with progress and prognosis of colorectal carcinoma显示文摘 | Brown DA Ward RL Buckhauhs P | 2003 | Clin Cancer Res2003，9，： | 1 |
| 10 | Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)显示文摘 | Truett GE Heeger P Mynatt RL | 2000 | Biotechniques2000，29，1： | 1 |
| 11 | Nutrition and physical activity and chronic disease prevention:research strategies and recommendations显示文摘 | Prentice RL Willett WC Greenwald P | 2004 | J Natl Cancer Inst2004，96，： | 1 |
| 12 | Increased ventral striatal monoaminergic innervation in Tourette syndrome 显示文摘 | Albin RL Koeppe RA Bohnen NI Nichols TE Meyer P Wernette K | 2003 | Neurology2003，61，3： | 1 |
| 13 | Gastric emptying and gastrointestinal transit of liq- uid in awake rats is delayed after acute myocardial infarction显示文摘 | CAMURCA F D QuEmoz D A F LEAL P RL | 2004 | Dig Dis Sci2004，49，5： | 1 |
| 14 | Cerebral vasospasm: looking beyond vasoconstriction 显示文摘 | Hansen-Schwartz J Vajkoczy P Macdonald RL | 2007 | Pharmacological Sciences2007，28，6： | 1 |
| 15 | Inhibition of autophagy impairs tumor cell invasion in an organotypic model 显示文摘 | Macintosh RL Timpson P Tborburn J | 2012 | Cell Cycle2012，11，10： | 1 |
| 16 | Intermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial显示文摘 | Lins RL Elseviers MM Van der Niepen P | 2009 | Nephrol Dial Transplant2009，24，2： | 1 |
| 17 | Clinical and pathological teatures of pachyonychia congenital显示文摘 | Leachman SA Kaspar RL Fleckman P | 2005 | J Investig Dermatol Symp Proc2005，10，： | 1 |
| 18 | Olfactory identification deficits in schizophrenia:correlation with duration of illness显示文摘 | Moberg P J Doty RL Turetsky BI Arnold SE Mahr RN Gur RC Bilker W Gur RE | | 0，，7： | 1 |
| 19 | Manage- ment of herpes simplex virus stromal keratitis: An evidence-based review显示文摘 | Knickelbein JE Hendricks RL Charukamnoetkanok P | 2009 | Surv Ophthalmol2009，54，2： | 1 |
| 20 | Excess mortality associated with increased pulse pressure among middle-aged men and women is explained by high systolic blood pressure显示文摘 | Antikainen RL Jousilahti P Vanhanen H | 2000 | J Hypertens2000，18，： | 1 |
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