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| 1 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 2 | Effects of trichothecene mycotoxins on eukaryotic cells: A review显示文摘 | Rocha O Ansari K Doohan F M | 2005 | Food Additives and Contaminants2005，22，4： | 1 |
| 3 | Analysis of public single nudeotide polymorphisms in commercial pig populations显示文摘 | KOLLERS S MEGY K ROCHA D | 2005 | Animal Genetics2005，36，： | 1 |
| 4 | Hilar cholangiocarcinoma:the Memorial Sloan-Kettering Cancer Center experience显示文摘 | Rocha FG Matsuo K Blumgart LH | 2010 | J Hepatobiliary Pancreat Sci2010，17，4： | 1 |
| 5 | The blumgart preoperative staging system for hilar cholangiocarcinoma:analysis of resectability and out- comes in 380 patients显示文摘 | Matsuo K Rocha FG Ito K | 2012 | J Am Coil Surg2012，215，3： | 1 |
| 6 | Water in car- bon dioxide macroemulsions and miniemulsions with a hydrocar- bon surfactant显示文摘 | Johnston K P Cho Dongman Da Rocha S R P | 2001 | Langmuir2001，17，23： | 1 |
| 7 | Isomerization of α-pinene oxide over cerium and tin catalysts: Selective synthesis of trans-carveol and trans-sobrerol显示文摘 | COSTA V V ROCHA K A SOUSA L F | 2011 | Journal of Molecular Catalysis A: Chemical2011，345，12： | 1 |
| 8 | 显示文摘 | Vasanth Kumar K Porkodl K Rocha F | 2008 | J Hazard Mater2008，150，1： | 1 |
| 9 | The blumgart preoperative staging system for hilar cholangiocarcinoma : analysis of resectabili- ty and outcomes in 380 patients显示文摘 | Matsuo K Rocha FG Ito K | 2012 | J Am Coil Surg2012，215，3： | 1 |
| 10 | Higherorder aberrations of age-related cataract 显示文摘 | Rocha KM Nose W Bottos K Bottos J Soriano E | 2007 | J Cataract Refract Surg2007，33，8： | 1 |
| 11 | Synthesis of 1,8-cineole and 1,4-cineole by isomerization of α-terpineol catalyzed by heteropoly acid显示文摘 | LE?O LANA E J DA SILVA ROCHA K A KOZHEVNIKOV I V | 2006 | Journal of Molecular Catalysis A:Chemical2006，259，12： | 1 |
| 12 | NIBBS-search for fast and accurate prediction of phenotype-biased metabolic systems显示文摘 | SCHMIDT M C ROCHA A M PAGMANABHANad K | 2012 | PLoS Computational Biology2012，8，10： | 1 |
| 13 | Regulation of NF- kappaB and p53 through activation of ATR and Chkl by the ARF tumour suppressor 显示文摘 | Rocha S Garrett M D Campbell K J | 2005 | EMBO J2005，24，6： | 1 |
| 14 | Phosphotungstic heteropoly acid as efficient heterogeneous catalyst for solvent-free isomeriza- tion of alpha-pinene and longifolene显示文摘 | Rocha K A D | 2009 | Applied Cataly- sis a-General2009，352，12： | 1 |
| 15 | Hilar cholangiocarcinoma:the memorial sloan-keuefing cancer center experience显示文摘 | Rocha FG Matsuo K Bhmgart LH et a1 | 2010 | JHepatobiliary Pancreat Sci2010，17，4： | 1 |
| 16 | Isomerisation of alpha-pinene oxide over silica supported heteropoly acid H3PW12O40 显示文摘 | Rocha K A D Kozhevnikov I V Gusevskaya E V | 2005 | Applied Catalysis a-Gen- eral2005，294，1： | 1 |
| 17 | Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation显示文摘 | Clave E Rocha V Talvensaari K | 2005 | Blood2005，105，6： | 1 |
| 18 | Effects of trichothecenemycotoxins on eukaryotic cells: a review显示文摘 | ROCHA O ANSARI K DOOHAN F M | 2005 | Food Additives andContaminants2005，22，： | 1 |
| 19 | Prevalence and Pathogenesis of Duodenal Ulcer in Chronic Alcoholic Pancreatitis显示文摘 | Julio Maria Fonseca Chebli Aécio Flávio Meirelles de Souza Pedro Duarte Gaburri Kátia Valeria Bastos Tarsila Campanha Rocha Ribeiro Roberto José Carvalho Filho Liliana Andrade Chebli Lincoln Eduardo V.V. Castro Ferreira | 2002 | Journal of Clinical Gastroenterology2002，，1： | 1 |
| 20 | Spherical aberration and depth of focus in eyes implanted with aspheric and spheri cal intraocular lenses: a prospective randomized study 显示文摘 | Rocha K M Soriano E S Chamon W | 2007 | Ophthalmology2007，114，11： | 1 |
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