|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | An automated system for preconcentration/matrix-removal followed by ICP-MS determination of organic phosphorus in oil production water 显示文摘 | Anderson A Rocha Norbert Miekeley Maria Carmen M Bezerra | 2004 | Micro- chemical Journal2004，78，1： | 1 |
| 4 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | Mesa-Perez J M Cortez L A B Rocha J D | 2005 | Fuel Processing Technology2005，86，5： | 1 |
| 5 | Pro- moters in Heterogeneous Catalysis : The Role of CI on Ethy- lene Epoxidation overAg 显示文摘 | Rocha T C R Haevecker M Knop-Gericke A | 2014 | J Catal2014，312，： | 1 |
| 6 | Immobilization of commercial laccase on spent grain显示文摘 | da Silva A M Tavare A P M Rocha C M R | 2012 | Process Biochem2012，479，7： | 1 |
| 7 | Effect of solids on homogeneous-heterogeneous flow regime transition in bubble cohimns 显示文摘 | Mena P C Ruzicka M C Rocha F A | 2005 | Chemical Engineering Science2005，60，22： | 1 |
| 8 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | L A B Cortez J D Rocha | 2005 | Fuel Processing Technology2005，86，： | 1 |
| 9 | Speciation of mercury using capillary electrophoresis coupled to volatile species generation-inductively coupled plasma mass spectrometry 显示文摘 | ROCHA M S SOLDADO A B BLANCO E | 2001 | J Anal At Spectom2001，，16： | 1 |
| 10 | Preoperative iden- tification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement显示文摘 | ROCHA E ALFARO M J PARAMO J A | 2008 | Thromb Haemost2008，59，： | 1 |
| 11 | Singular value decomposition and principal component analysis显示文摘 | WALL M E RECHTSTEINER A ROCHA L M | 2002 | A Practical Approach to Microarray Data Analysis2002，，5： | 1 |
| 12 | Molecular char acterization and seasonal changes in gonadal expression of a thyrotropin receptor in the european sea bass显示文摘 | Rocha A Gomez A Galay-Burgos M | 2007 | Gen Comp Endocrinol2007，152，1： | 1 |
| 13 | Lipase immobilization onto polymeric membrance 显示文摘 | CARNERIRO-da-CUNDA M C ROCHA J M S GARCIA F A P | 1979 | Biotechnol Techniques1979，13，： | 1 |
| 14 | Polyphenoloxidase activity and total phenolic content as related to browning of minimally processed' Jonagored' apple显示文摘 | Rocha A M Morals A M | 2002 | Journal of the Science of Food and Agriculture2002，82，1： | 1 |
| 15 | Facial nerve in rhytidoplasty:anatomic study of its trajectory in the overlying skin and the most common sites of injury显示文摘 | FADUL R Jr Da ROCHA M A | 2003 | Ann Plast Surg2003，51，3： | 1 |
| 16 | 显示文摘 | Vieira M Rocha E Silva A Silva E | 2012 | Rev Port Cir Cardiotorac Vase2012，19，3： | 1 |
| 17 | 3xP3-EGFP maker facilitates screening for transgenic silkworm Bombyx moriL, from the embryonic stage onwards 显示文摘 | THOMAS J L DA ROCHA M BESSE A | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 18 | Effects of Non-nutritive Sucking and Oral Stimulation on Breastfeed- ing Rates for Preterm,Low Birth Weight Infants: a Random- ized Clinical Trial显示文摘 | Pimenta H P Moreira M E Rocha A D | 2008 | J Pediatr (Rio J)2008，84，5： | 1 |
| 19 | Distinct stem cells contribute to mammary gland development and maintenance显示文摘 | Van Keymeulen A Rocha A S Ousset M et a1 | 2011 | Nature2011，479，7372： | 1 |
| 20 | State of the art in the development of biomimetic oxidation catalysts显示文摘 | Rocha Gonsalves A M Pereira M | 1996 | J Mol Catal A:Chem1996，113，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员