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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Pro- moters in Heterogeneous Catalysis : The Role of CI on Ethy- lene Epoxidation overAg 显示文摘 | Rocha T C R Haevecker M Knop-Gericke A | 2014 | J Catal2014，312，： | 1 |
| 3 | Immobilization of commercial laccase on spent grain显示文摘 | da Silva A M Tavare A P M Rocha C M R | 2012 | Process Biochem2012，479，7： | 1 |
| 4 | Acute generalized, widespread bleeding, diagnosis and management显示文摘 | ROCHA E PARAMO J A MONTES R | 1998 | Haematologica1998，83，： | 1 |
| 5 | Differentially expressed angiogenic genes in diabetic erectile tissue-results from a microarray screening显示文摘 | CASTELA A SOARES R ROCHA F | 2012 | Mol Genet Metab2012，105，2： | 1 |
| 6 | Altered expression of activin, cripto, and follistatin in the endometrium of women with endometrioma显示文摘 | Rocha A L Carrarelli P Novembri R | 2011 | Fertil Steril2011，95，7： | 1 |
| 7 | Chloroplast-localized protein kinases:A step forward towards a complete inventory显示文摘 | BAYER R G STAEL S ROCHA A G | 2012 | Journal of Experimental Botany2012，63，4： | 1 |
| 8 | Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats显示文摘 | Blasi E R Rocha R Rudolph A E | 2003 | Kidney Int2003，63，5： | 1 |
| 9 | Wet depositionand related atmospheric chemistry in the S(a)o Paulo Metropolis,Brazil:Part 1-Major inorganic ions in rainwater as evaluated by capillary electrophoresis with contactless conductivity detection显示文摘 | F R Rocha S Fracassi A José | 2003 | Atmos Environ2003，37，： | 1 |
| 10 | Facial nerve in rhytidoplasty:anatomic study of its trajectory in the overlying skin and the most common sites of injury显示文摘 | FADUL R Jr Da ROCHA M A | 2003 | Ann Plast Surg2003，51，3： | 1 |
| 11 | Hydrothermal origin of soft hematite ore in the Quadrildtero Ferrifero of Minas Gerais,BrazilPetrographic evidence from the Gongo Soco iron ore deposit显示文摘 | Cabral A R Rocha Filho 0 G Jones R D | 2003 | Applied Earth Science: Trans Inst Min Metall B2003，112，： | 1 |
| 12 | Effect of dissolved oxygen concentration on planktonic foraminifera through laboratory culture experiments and implications for oceanic anoxic events 显示文摘 | Kuroyanagi A da Rocha R E Bijma J | 2013 | Marine Micropaleontology2013，101，1： | 1 |
| 13 | Autoradiographic study of serotonin transporter during memory formation显示文摘 | Tellez R Rocha L Castillo C Meneses A | | 0，，： | 1 |
| 14 | Role of aldoste-rone in renal vascular injury in stroke-prone hypertensive rats显示文摘 | Rocha R Chander PN Zuckerman A | | 0，，1： | 1 |
| 15 | Mass transfer in gauze packings显示文摘 | Bravo J L Rocha J A Fair J R | 1985 | Hydrocarbon Processing1985，64，： | 1 |
| 16 | Use of rice straw as biosorbent for removal of Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ)and Hg(Ⅱ)ion in industrial effluent显示文摘 | ROCHA C G ZZIA D A ALFAYA R V | 2009 | Journal of Hazardous Material2009，166，： | 1 |
| 17 | Serum Hsp70 as an ealry perdictor of fatal outcome after severe traumatic brain injury in males显示文摘 | da Rocha A B Zanoni C de Freitas G R | 2005 | J Neuortrauma2005，22，9： | 1 |
| 18 | 查看详情显示文摘 | Rocha R A Muccillo E N S | | 0，，1： | 1 |
| 19 | Pressure drop instructure packings显示文摘 | Bravo J L Rocha J A Fair J R | 1986 | Hydrocarbon Processing1986，3，： | 1 |
| 20 | Visual function and patient experience after bilateral implantation of toric intraocular lenses 显示文摘 | Ahmed I I Rocha G Slomovic A R | 2010 | J Cataract Refract Surg2010，36，4： | 1 |
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