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| 1 | Incidence of gallstone disease in Italy:Results from a multicenter,population-based Italian study (the MICOL project)显示文摘AIM:To evaluate gallstone incidence and risk factors in a large population-based study. METHODS: Gallstone incidence and risk factors, were evaluated by structured questionnaire and physical examination, respectively, in 9611 of 11 109 (86.5%) subjects who were gallstone-free at the cross-sectional study. RESULTS: Six centers throughout Italy enrolled 9611 subjects (5477 males, 4134 females, aged 30-79 years), 9517 of whom were included into analysis: 424 subjects (4.4%) had gallstones and 61 (0.6%) had been cholecystectomized yielding a cumulative incidence of 0.67% per year (0.66% in males, 0.81% in females). Increasing age, a high body mass index (BMI), a history of diabetes, peptic ulcer and angina, and low cholesterol and high triglyceride levels were identifi ed as risk factors in men while, in females, the only risk factors were increasing age and a high BMI.Increasing age and pain in the right hypocondrium in men and increasing age in females were identifi ed as predictors of gallstones. Pain in the epigastrium/ right hypocondrium was the only symptom related to gallstones; furthermore, some characteristics of pain (forcing to rest, not relieved by bowel movements) were significantly associated with gallstones. No correlation was found between gallstone characteristics and clinical manifestations, while increasing age in men and increasing age and BMI in females were predictors of pain. CONCLUSION:Increasing age and BMI represent true risk factors for gallstone disease (GD); pain in the right hypocondrium and/or epigastrium is confi rmed as the only symptom related to gallstones. | Davide Festi Ada Dormi Simona Capodicasa Tommaso Staniscia Adolfo F Attili Paola Loria Paolo Pazzi Giuseppe Mazzella Claudia Sama Enrico Roda Antonio Colecchia | 2008 | World Journal of Gastroenterology2008，14，34： | 23 |
| 2 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 3 | Separation techniques for bile salts analysis显示文摘 | RODA A PIAZZA F BARALDINI M | 1998 | J Chromatogr B1998，717，12： | 1 |
| 4 | Serpentine aneurysm: regrowth after a superficial temporal artery-middle cerebral ar- tery bypass and internal carotid artery ligation: case report显示文摘 | ISLA A ALVAREZ F RODA JM | 1994 | Neurosurgery1994，34，6： | 1 |
| 5 | The intraluminal thread model revisited :rat strain differences in local cerebral blood flow显示文摘 | Prieto R Carceller F Roda JM | 2005 | Neural Res2005，27，1： | 1 |
| 6 | A rapid and sensitive 384-microtiter wells format chemiluminescent enzyme immunoassay for clenbuterol显示文摘 | Roda A Manetta A C Piazza F | 2000 | Talanta2000，52，2： | 1 |
| 7 | Anatomic and Hemodynamic Study of Anterior Communicating Artery Complex显示文摘 | Gonzale Llanos F Pascual J M Roda J M | 2002 | Neurocirugia2002，13，4： | 1 |
| 8 | The intraluminal thread model revisited:Rat strain differences in local cerebral blood flow显示文摘 | Prieto R Carceller F Roda JM | 2005 | Neurol Res2005，27，： | 1 |
| 9 | Anatomic and hemodynamic study of anterior communicating artery complex 显示文摘 | Gonzdlez-Llamos F Pascual JM Roda JM | 2002 | Neurocirugia (Astur)2002，13，4： | 1 |
| 10 | The intraluminal thread model revisited:rat stain differences in local cerebral blood flow显示文摘 | Carceller F Roda JM | 2005 | Neurol Res2005，27，1： | 1 |
| 11 | Separation techniques for bile salts analysis 显示文摘 | Roda A Piazza F Baraldini M | 1998 | J Chromatogr B Biomed Sci Appl1998，717，12： | 1 |
| 12 | Tourmaline in granitic pegmatites and their country rocks,Fregeneda area,Salamanca,Spain显示文摘 | Roda E Pesquera A Velasco F | 1995 | Can Mineral1995，33，： | 1 |
| 13 | A rapid and sensitive 384microtiter wells format chemiluminescent enzyme immunoassay for clenbuterol显示文摘 | Roda A Manetta A C Piazza F | 2000 | Talanta2000，52，： | 1 |
| 14 | Taurohyodeoxycholic acid protects against taurocheno-deoxycholic acid-induced cholestasis in the rat显示文摘 | Roda A Piazza F Baraldini M | 1998 | Hepatology1998，27，2： | 1 |
| 15 | The intralumi-nal thread model revisited: rat strain differences in local cerebral blood flow 显示文摘 | Prieto R Carceller F Roda ]M | 2005 | Neurol Res2005，27，1： | 1 |
| 16 | A rapid and sensitive 384-microtiter wells format chemiluminescentenzyme immunoassay for clenbuterol显示文摘 | Roda A Manetta A C Piazza F Simoni F Lelli R | 2000 | Talanta2000，52，： | 1 |
| 17 | The intraluminal thread model revisited:rat strain differences in local cerebral blood flow显示文摘 | Carceller F Roda JM | 2005 | Neurol Res2005，27，： | 1 |
| 18 | The intraluminal thread model revisited:rat strain differences in local cerebral blood flow显示文摘 | Prieto R Carceller F Roda JM | 2005 | Neurol Res2005，27，1： | 1 |
| 19 | Plasticity of leaf morphological traits, leaf nutrient content, and water capture in the Mediterra- nean evergreen oak Quercus ilex subsp ballota in response to fertili- zation and changes in competitive conditions 显示文摘 | Sardans J Pennuelas J Roda F | 2006 | Ecoscience2006，13，2： | 1 |
| 20 | Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia显示文摘 | Roda JM Carceller F Diez-Tejedor E | 1995 | Stroke1995，26，： | 1 |
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