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| 1 | Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes显示文摘BACKGROUND A number of recent studies indicate a transformation in the natural course of chronic kidney disease(CKD)in type 2 diabetes(T2D)patients:an increasing prevalence of declined renal function without proceeding to the accompanying elevation of albuminuria.It has been suggested that albuminuric and nonalbuminuric CKD patterns could be different in their phenotypes and pathogenic mechanisms.AIM To identify the risk factors and biomarkers of albuminuric and non-albuminuric patterns of CKD in patients with T2D.METHODS Three hundred sixty patients with T2D duration≥10 years were included in this observational cross-sectional study.The associations of a panel of demographic and clinical characteristics,complications,comorbidities,and metabolic and hematology parameters with albuminuric and non-albuminuric CKD patterns were analyzed.The urinary excretion of nephrin and podocin,two podocytespecific markers,and WAP-four-disulfide core domain protein 2(WFDC-2),a marker of tubulointerstitial fibrosis,was determined by ELISA in comparison with healthy controls.RESULTS Non-albuminuric CKD was associated with age≥65 years(P=0.0001),female sex(P=0.04),diabetes duration≥15 years(P=0.0009),and the use of diuretics(P=0.0005).Male sex(P=0.01),smoking(P=0.01),waist-to-hip ratio>1.0(P=0.01)and hemoglobin A1c(HbA1c)>8.0%(P=0.005)were risk factors for elevated albuminuria not accompanied by a decrease in estimated glomerular filtration rate(eGFR).Duration of diabetes≥15 years and the use of calcium channel blockers were risk factors for albuminuria with decreased eGFR(both P=0.01).In multivariate logistic regression analysis,age,HbA1c,female sex and diuretics were significant predictors for reduced eGFR,while waist-to-hip ratio,HbA1c and male sex were associated with elevated urinary albumin-to-creatinine ratio(UACR).Excretion of nephrin and podocin was increased in patients with albuminuria,regardless of decline in renal function(P<0.001),correlating positively with UACR.The urinary excretion of WFDC-2 was markedly higher in men than in women(P<0.000001).Men with T2D demonstrated increased WFDC-2 levels independently of the CKD pattern(all P<0.05).In T2D women,WFDC-2 excretion was increased in those with reduced renal function(P≤0.01),correlating negatively with eGFR.CONCLUSION The data provide further evidence that albuminuric and non-albuminuric CKD phenotypes correspond to different pathways of diabetic kidney disease progression. | Anton I Korbut Vadim V Klimontov Ilya V Vinogradov Vyacheslav V Romanov | 2019 | World Journal of Diabetes2019，10，11： | 3 |
| 2 | Magnetic properties and hyperfine interactions in the β″ phase of potassium ferrite 显示文摘 | Romanov V P Candela G A Roth R S | 1979 | J Appl Phys1979，50，： | 1 |
| 3 | Petroleum migration and trapping mechanism in fine-grained source rock for marion 显示文摘 | Lopatin N V Emets T P Romanov E A | 2003 | Journal of Geochemical Exploration2003，，7879： | 1 |
| 4 | Egg physical characteristics and hatchability显示文摘 | Narushin V G Romanov M N | 2002 | World''s Poultry Science Journal2002，58，： | 1 |
| 5 | Inter-fiber stresses in composites with carbon nanotube grafted and coated fibers 显示文摘 | Romanov V Lomov S V Verpoest I | 2015 | Composites Science and Technology2015，114，： | 1 |
| 6 | Explicit identification of multiple small breast cancers in an optical mammographic imaging显示文摘 | HE Sai-ling ZHANG Hang ROMANOV V G | 2002 | Inverse Problems2002，18，1： | 1 |
| 7 | Therapeutic po- tential of RGD peptides in acute renal injury 显示文摘 | Goligorsky MS Noiri E Kessler H Romanov V | 1997 | Kidney Int1997，51，5： | 1 |
| 8 | Searching for alternative sources of postnatal human mesenchymal stem cells:c:andidate MSC-like cells fromumbilical cord显示文摘 | Romanov Y A Svintsitskaya V A Smirnov V N | 2003 | Stem Cells2003，21，： | 1 |
| 9 | Preparation of hydrocellulose fibres fr- om highly concentrated solutions of cellulose in N-methylmorphine- N-oxide显示文摘 | ROMANOV V V LUNINA O B | 1993 | Fibre Chemistry1993，25，5： | 1 |
| 10 | Volumetric effects in coal sorption capacity measurements显示文摘 | Romanov V N Soong Y Schroeder K | 2006 | Chem Eng Technol2006，，29： | 1 |
| 11 | Errors in CO2 adsorption measurements caused by coal swelling 显示文摘 | Romanov V N Goodman A L Larsen J W | 2006 | Energy Fuel2006，20，： | 1 |
| 12 | Light Scattering in Cholesteric Liquid Crystals with a Large Pitch显示文摘 | AKSENOVA E V VALKOV A Y ROMANOV V P | 2004 | JOURNAL OF EXPERIMENTAL AND THEORETICAL PHYSICS2004，98，1： | 1 |
| 13 | Searching for alternative sources of postnatal human mesenchymal stem cells:candidate MSC-like cells from umbilical cord显示文摘 | Romanov Y A Svintsitskaya V A Smirnov V N | | 0，，： | 1 |
| 14 | Modification of the spontaneous emission of CdTe nanocrystals in TiO2 inverted opals显示文摘 | SOLOVYEV V G ROMANOV S G TORRES C M S | 2003 | J Appl Phys2003，94，2： | 1 |
| 15 | Inverse problems of 3D ultrasonic tomography with complete and incomplete range data 显示文摘 | GONCHARSKY A V ROMANOV S Y SERYOZHNIKOV S Y | 2014 | Wave Motion2014，51，3： | 1 |
| 16 | Electronic structure of (n,0) zigzag carbon nanotubes:Cluster and crystal approach显示文摘 | Okotrub A V Romanov D A | 1998 | Phys Chem A1998，，102： | 1 |
| 17 | Errors in CO2 adsorption measurements caused by swelling显示文摘 | ROMANOV V N GOODMAN A L LARSEN J W | 2006 | Energy Fuels2006，20，： | 1 |
| 18 | Neuronal or- ganization of the telencephalon in the Chum Salmon Onchor- hynchus keta 显示文摘 | Pushchina E V Varaksin A A Romanov N S | 2003 | Russian Journal of Marine Biology2003，29，6： | 1 |
| 19 | Pathophysiology of renal tubular obstruction:therapeutic role of synthetic RGD peptides in acute renal failure显示文摘 | Romanov V Forest T et at | 1995 | Kidney International1995，48，： | 1 |
| 20 | Egg physical characteristics and hatchability显示文摘 | Narushin V G Romanov M N | 2002 | World''s Poultry Science Journal2002，58，： | 1 |
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