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| 1 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Delayed leaf senescence induces extreme drought tolerance in a flowering plant显示文摘 | Rosa M R Mikiko K Amira G | 2007 | Proceedings of the National Academy of Sciences2007，104，19： | 1 |
| 3 | Funding systems for higher education and their impacts on institutional strategies and academia:A comparative perspective显示文摘 | Frlich N Schmidt E K Rosa M J | 2010 | International Journal of Educational Management2010，24，1： | 1 |
| 4 | Green clay and aloe vera peel-off facial masks:response surface methodology applied to the formulation design显示文摘 | Beringhs A O Rosa J M Stulzer H K | 2013 | American Association of Pharmaccu- tical Scientists2013，14，1： | 1 |
| 5 | Determination of dopamine by flow - injection analysis coupled with luminol- hexacyanoferrate(Ⅲ) chemiluminescence detection 显示文摘 | Edyta N R Rosa B Anatol K | 2004 | J Pharma and Biomed Anal2004，36，1： | 1 |
| 6 | Macroscopic and histological effects of magnetic field exposi- tion in the process of tissue reparation in Wistar rats显示文摘 | Bertolino G De Freitas Braga A De Oliveira Limado Couto Rosa K | 2006 | Arch Der- matol Res2006，298，： | 1 |
| 7 | Efficient constitutive expression of Bacillus subtilis xylanase A in Eseherichia coil DH5alpha under the control of the Bacillus BsXA promoter显示文摘 | Kuller K Rosa J C Faca V M | 2006 | Biotechnol Appl Biochem2006，43，1： | 1 |
| 8 | Induction of oxidative stress by L-2-hydroxyglutaric acid in rat brain显示文摘 | Latini A Scussiato K Rosa R B | 2003 | J Neurosci Res2003，74，： | 1 |
| 9 | Glucosinolate in crops plants显示文摘 | Rosa E A S Heaney R K Fenwick G R Fenwick G R | 1997 | Hort Rev1997，19，： | 1 |
| 10 | Proximal decom- position via alternating linearization显示文摘 | Kiwiel K C Rosa C H R Uszczynski A | 1999 | SIAM J Optim1999，9，3： | 1 |
| 11 | Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology显示文摘 | Rosas L E Satoskar A A Roth K M | | 0，，01： | 1 |
| 12 | An improved state-space method for coupled fluid-structure interaction analysis显示文摘 | CUNEFARE K A ROSA S D | 1999 | Journal of the Acoustical Society of America1999，105，1： | 1 |
| 13 | Streptococcus bovis infectious endocafditis; clinical and epidemiological characteristics显示文摘 | Massamni K FrancavilIa R De Rosa FG | 2011 | Infez Me2011，11，4： | 1 |
| 14 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 15 | Absorption spectra of the mono-adduct and eight bis-adduct regioisomers of pyrrolidine derivatives of C60显示文摘 | Da Rosa T Pratoa M | 2003 | Chemical Physics2003，293，： | 1 |
| 16 | Monocyte chemoattractant-1 as a urinary biomarker for the diagnosis of activity of lupus nephritis in Brazilian patients显示文摘 | Rosa RF Takei K Araújo NC | 2012 | J Rheumatol2012，39，： | 1 |
| 17 | Mob- ility enhancements for LTE- advanced muhilayer networks with inter-site carrier aggregation 显示文摘 | PEDERSEN K I MICHAELSEN P H ROSA C | 2013 | IEEE communica- tions magazine2013，51，5： | 1 |
| 18 | Glucosinolates in crop plants 显示文摘 | Rosa E Heaney K R Fenwick R | 1997 | Horticultural Reviews1997，19，： | 1 |
| 19 | Taxonomic revision of the genus Trichinella显示文摘 | Pozio E La Rosa G Murrel K D | 1992 | J Parasltol1992，78，4： | 1 |
| 20 | Structure and regulation of amiloride- sensitive sodium channels 显示文摘 | ALVAREZ DE LA ROSA D CANESSA C M FY FE G K | 2000 | Annu Rev Physiol2000，62，： | 1 |
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