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| 1 | Surgical management of polycystic liver disease显示文摘Adult polycystic liver disease (PCLD) is an autosomal dominant condition commonly associated with autosomal dominant polycystic kidney disease (ADPKD). However in the last decade, it has been recognized that there is a distinct form of autosomal dominant PCLD that arises without concomitant ADPKD. Early knowledge of the pathogenesis was gained from the study of hepatic cysts in patients with ADPKD. Bile duct overgrowth after embryogenesis results in cystic hepatic dilatations that are known as biliary microhamartomas or von Meyenburg complexes. Further dilatation arises from cellular proliferation and fluid secretion into these cysts. There is a variable, broad spectrum of manifestations of PCLD. Although PCLD is most often asymptomatic, massive hepatomegaly can lead to disabling symptoms of abdominal pain, early satiety, persistent nausea, dyspnea, ascites, biliary obstruction, and lower body edema. Complications of PCLD include cyst rupture and cyst infection. Also, there are associated medical problems, especially intracranial aneurysms and valvular heart disease, which clinicians need to be aware of and evaluate in patients with PCLD. In asymptomatic patients, no treatment is indicated for PCLD. In the symptomatic patient, surgical therapy is the mainstay of treatment tailored to the extent of disease for each patient. Management options include cyst aspiration and sclerosis, open or laparoscopic fenestration, liver resection with fenestration, and liver transplantation. The surgical literature discussing treatment of PCLD, including techniques, outcomes, and complication rates, are summarized in this review. | Robert T Russell C Wright Pinson | 2007 | World Journal of Gastroenterology2007，13，38： | 20 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Experimental Determination of Fre-quencies and Tension for Elastic Cables显示文摘 | Lardner T J | 1998 | Journal of Engi-neering Machanics ASCE1998，124，10： | 1 |
| 4 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，96： | 1 |
| 5 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 6 | All si-lica single-mode optical fiber with photonic crystal cladding显示文摘 | Knight J C Birks T A Russell P St J | 1996 | Optics Letters1996，21，19： | 1 |
| 7 | Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline显示文摘 | Kidd T Russell C Goodman CS | 1998 | Neuron1998，20，1： | 1 |
| 8 | Covergence analysis of an approximations of miscible displacement in porous media by mixed finite element and a modified method of characteristics显示文摘 | Ewing R C Russell T F Wheeler M F | 1984 | Computer Methods in Applied Mechanics and Engineering1984，47，1： | 1 |
| 9 | All-silica single-mode optical fiber with photonic crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 10 | Antigenic and genetic characteristics of swine-origin 2009 A (HIN1) influenza viruses circulating in humans 显示文摘 | GARTEN R J DAVES C T RUSSELL C A | 2009 | Science2009，325，： | 1 |
| 11 | All-silica single-mode optic fiber with photonic with photonic Crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，15： | 1 |
| 12 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 13 | Cast metal composites reinforced by SiC particles显示文摘 | FLETCHER T R CORNIE J A RUSSELL K C | 1988 | Metal and Materials1988，23，9： | 1 |
| 14 | A generalized approach to the modification of solid surfaces显示文摘 | Ryu D Y Shin K Drockenmuller K Hawker C J Russell T P | 2005 | Science2005，308，： | 1 |
| 15 | All-sillica single-mode optical fiber with photonic crystal cladding 显示文摘 | Knight J C Briks T A Russel P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 16 | Ultrahigh-density nanowire arrays grown in self-assembled diblock copolymer templates显示文摘 | TURN A T SCHOTTER J KAESTLE G A EMLEY N SHIBAUCHI T KRUSIN E L GUARINI K BLACK C T TUOMINEN M T RUSSELL T P | 2000 | Science2000，290，5499： | 1 |
| 17 | Experimental Determina-tion of Frequencies and Tension for Elastic Cable显示文摘 | Russell J C Lardner T J | 1998 | Journal of Engineering Mechanics1998，124，10： | 1 |
| 18 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 19 | Experimental determination of fre-quencies and tension for elastic cables 显示文摘 | Russell J C Lardner T J | 1998 | Journal of Engineering Mechanics1998，124，10： | 1 |
| 20 | End-lessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
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