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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | On the Calculation of the Spectroscopic Term Derived from Equivalent Electrons 显示文摘 | Russel H N | 1927 | Phys Rev1927，29，6： | 2 |
| 5 | Hemorrhagic shock increases gut macromolecular permeability in the rat 显示文摘 | Russell D H Barreto J C Klemm K | 1995 | Shock1995，4，： | 1 |
| 6 | 显示文摘 | Russel T P Gugger H Swalen J D | 1983 | J Polym Sci Polym Phys Ed1983，21，： | 1 |
| 7 | Fault diagnosis in chemical processes using Fisher discriminant analysis,discriminant partial least squares,and principal component analysis显示文摘 | Chiang L H Russell E L Braatz R D | 2000 | Chemometrics and Intelligent Laboratory Systems2000，50，2： | 1 |
| 8 | 查看详情显示文摘 | James I L Tom D M Salah E Andrew F Karl H S Russell P N | | 0，，： | 1 |
| 9 | Outcomes of radial in- cision of the tricuspid valve fur ventrieular septal delct elosme 显示文摘 | Russell H M Forsberg K Backer C L ct al | 2011 | Ann Thorac Surg2011，92，2： | 1 |
| 10 | Effect of epistasis on grain yield in maize显示文摘 | Sprague G E Russel W A Penny L H | 1962 | Crop Sci1962，2，： | 1 |
| 11 | Fluidproperty discrimination with AVO:A Biot-Gassmann perspective显示文摘 | Hedlin K Hilterman F J | 2003 | Geophysics2003，68，1： | 1 |
| 12 | Antigenic and biological characterisatien of avian paramyxovirus type Ⅰ isolates from pigenns-an international collaborative study显示文摘 | Alexander D J Russell P H Parsons G | 1985 | Avian Pathol1985，14，： | 1 |
| 13 | The design of gas sparged devices for viscous liquid systems显示文摘 | Bhavaraju S M Russell T W F Blanch H W | 1978 | AIChE Journal1978，24，3： | 1 |
| 14 | Differential effects of hep-atitis C virus JFH1 on human myeloid and plasmacytoid dendriticcells显示文摘 | Liang H Russell RS Yonkers NL | 2009 | J Virol2009，83，11： | 1 |
| 15 | Insecticide effect on three Tephritid fruit flies and associated braconid parasitoids in Hawaii显示文摘 | Mary F Purcell John D Stark Russell H Messing | 1994 | Econ Entomol1994，87，6： | 1 |
| 16 | Violaceae of the Southeastern United States显示文摘 | LANDON E MCKINNEY NNORMAN H RUSSELL | 2002 | Castanea2002，67，4： | 1 |
| 17 | Effect of pyrophosphate on hydroxyapatite and its complications in calcium homeostasis 显示文摘 | Fieisch H Russell RGG Straumann F | 1966 | Nature1966，212，： | 1 |
| 18 | Shear strength of high-strength concrete beams with web reinforcement 显示文摘 | Roller J J Russell H G | 1990 | ACI Structural Journal1990，87，2： | 1 |
| 19 | Effectiveness of short- term, enhanced, infection control support in improving com- pliance with infection control guidelines and practice in nurs- ing homes: a cluster randomized trial显示文摘 | Gopal Rao G Jeanes A Russell H | 2009 | Epidemiology and Infection2009，137，10： | 1 |
| 20 | The origin, composition and rates of organic nitrogen deposition: A missing piece of the nitrogen cycle? 显示文摘 | NeffJ C Holland E A Dentener F J McDowell W H Russell K M | 2002 | Bio- geochemistry2002，57，1： | 1 |
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