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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | An IR spectroscopic study of soil humin and its relationship to other soil humic substances and fungal pigments 显示文摘 | Russell J D Vanghan D Jones D | 1983 | Geoderma1983，29，： | 2 |
| 3 | Elevated plasma levels of human urotensin-Ⅱimmunoreactivity in congestive heart failure显示文摘 | Russell F D Meyers D Galbraith A J | 2003 | Am J Physiol Heart Circ Physiol2003，285，4： | 2 |
| 4 | Characterization of flavonoids in cranberry (Vaccinium macrocarpon) powder显示文摘 | VVEDENSKAYA I O ROSEN R T GUIDO J E RUSSELL D J MILLS K A VORSA N | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 5 | Modeling the crystal-field splitting of energy levels of Era* (4f11 ) in charge-compensated sites of KPbzC15 显示文摘 | GRUBER J B YOW R M NIJJAR A S NIJJAR C RUSSELL C SARDAR D J | 2006 | J Appl Phys2006，100，04： | 1 |
| 6 | Two Field Tests of an Explanation for Assessment Center Ratings显示文摘 | Russell C J Domm D R | 1995 | Journal of Occupational and Organizational Psychology1995，68，1： | 1 |
| 7 | Hemorrhagic shock increases gut macromolecular permeability in the rat 显示文摘 | Russell D H Barreto J C Klemm K | 1995 | Shock1995，4，： | 1 |
| 8 | Pulse-based dead-time compensator for PWM voltage inverters 显示文摘 | LEGGATE D RUSSELL J K | 1997 | IEEE Trans on Ind Electron1997，44，2： | 1 |
| 9 | 显示文摘 | Russel T P Gugger H Swalen J D | 1983 | J Polym Sci Polym Phys Ed1983，21，： | 1 |
| 10 | Procedure for developing truck accident and release rates for HAZMAT routing 显示文摘 | Harwood D W Viner J G Russell E R | 1993 | Journal of Transportation Engineering1993，119，2： | 1 |
| 11 | Developing a draft schedule using templates and rules 显示文摘 | Nicola J Chevallier Alan D Russell | 2001 | Journal of Construction Engineer- ing and Management2001，127，5： | 1 |
| 12 | Studies on blends of epoxy-funetionalized hyperbranched polymer and epoxy resin 显示文摘 | PATNA D VARLEY RUSSELL J SINGH RAMAN RK | 2003 | Journal of Material Science2003，38，1： | 1 |
| 13 | Direct comparison of levels of genetic variation among barley accessions detected by RFLPs, AFLPs, SSRs and RAPDs显示文摘 | Russell J R Fuller J D Macaulay M | 1997 | Theoretical and Applied Genetics1997，95，： | 1 |
| 14 | Antigenic and biological characterisatien of avian paramyxovirus type Ⅰ isolates from pigenns-an international collaborative study显示文摘 | Alexander D J Russell P H Parsons G | 1985 | Avian Pathol1985，14，： | 1 |
| 15 | Possible link between bacterial resistance and use of antibiotics and biocides显示文摘 | RUSSELL A D TATTAWASART U MAILJARD J Y | 1998 | Antimicrob Agents Chemother1998，42，8： | 1 |
| 16 | Accurate transcription initiation by RNA polymerase Ⅱ in a soluble extract from isolated mammalian nucle显示文摘 | DIGNAM J D RUSSELL M L ROEDER R G | 1993 | Nucleic Acids Res1993，12，5： | 1 |
| 17 | Purification, prop- erties, and distribution of ascorbate peroxidase in legume root nodules 显示文摘 | Dalton D A Hanus J F Russell S A | 2006 | Plant Physiol2006，83，： | 1 |
| 18 | Development of a core set of SSR markers for the characterization of Gossypium germplasm显示文摘 | JOHON Z Y David D F Russell J K | 2012 | Euphytica2012，187，2： | 1 |
| 19 | Judgment of fit in the selection process: the role of work-value congruence 显示文摘 | ADKINS C L RUSSEL C J WERBEL J D | 1994 | Personnel Psychology1994，47，3： | 1 |
| 20 | Engireering targe- ted viral vectors for gene therapy显示文摘 | WAEHLER R RUSSELL S J CURIEL D T | 2007 | Nat Rev Genet2007，8，8： | 1 |
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