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| 1 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 2 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 3 | Microstrucmre and Compression Behaviour in the Semisolid State of Short-fiber-reinforced A356 Aluminum Alloys显示文摘 | Thanh L Sue'ry M | 1995 | Materials Science and Engineering A1995，196，： | 1 |
| 4 | The global burden of occupational noise-induced hearing loss显示文摘 | Nelson DI Nelson RY Concha-Barrientos M | 2005 | Am J lnd Med2005，48，6： | 1 |
| 5 | Generalized F acceler- ated failure time model for mapping survival trait loci显示文摘 | Zhou X J Fang M Yang RY | 2011 | Genomics2011，97，6： | 1 |
| 6 | PET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis显示文摘 | Chen RY Dodd LE Lee M | 2014 | Sci Transl Med2014，6，265： | 1 |
| 7 | The presence of a newly identified infectious agent (SEN virus)in patients with liver diseases and in blood domors in Japan显示文摘 | Shibata M Wang RY Yoshiba M | 2001 | J Infect Dis2001，184，4： | 1 |
| 8 | An update on mutations of the SLC39A4 gene in acrodermatitis enteropathica显示文摘 | Schmitt S Küry S Giraud M | 2009 | Hum Mutat2009，30，6： | 1 |
| 9 | A New Generation of Ca2+ Indicators with Greatly Improved Fluorescence Properties显示文摘 | Grynkiewicz G Poenie M Tsien RY | 1985 | J Bio Chamistry1985，260，： | 1 |
| 10 | TSH stimulates adipogenesis in mouse embryonic stem cells显示文摘 | Lu M Lin RY | 2008 | J Endocrinol2008，196，1： | 1 |
| 11 | Real-time strain rate echocardiographic imaging:temporal and spatial analysis of postsystolic compression in acutely ischemic myocardium显示文摘 | Pislaru C Bae RY | 2001 | J Am Soc Echocardiogr2001，14，5： | 1 |
| 12 | Proteomic analysis of dendritic cell-derived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles显示文摘 | Théry C Boussac M Véron P | 2001 | J Immunol2001，166，12： | 1 |
| 13 | Changes in globus palli-dus with (pre) term kernicterus 显示文摘 | Govaert P Lequin M Swarte RY | 2003 | Pediatrics2003，112，6： | 1 |
| 14 | Predictors of surgery in patients with severe acute pancreatitis managed by the step-up approach显示文摘 | Babu RY Gupta R Kang M | 2013 | Ann Surg2013，257，4： | 1 |
| 15 | Natriuretic Peptide system andthe heart 显示文摘 | Del Ry S Cabiati M Clerico A | 2014 | Front Horm Res2014，43，： | 1 |
| 16 | Natriur- etic peptide system and the heart显示文摘 | Del Ry S Cabiati M Clerico A | 2014 | Front Home Res2014，43，： | 1 |
| 17 | C-type natriuretic peptide and its relationto non-invasive indices of left ventricular function in patients with chronic eart failure显示文摘 | Del Ry S Maltinti M | 2008 | Peptides2008，29，1： | 1 |
| 18 | Association of HLA class I with severe acute respiratory syndrome coronavirus infection显示文摘 | Line M Tseng HK Trejaut JA Lee IlL Loo JH Chu CC Chert PJ Su YW Lira KH Tsai ZU Lin RY Lin RS and Huang CH | 2003 | BMC Med Genet2003，4，： | 1 |
| 19 | Photosynthesis and Activity of Phosphoenolpyruvate carboxylase in Nicotiana tabacum L. Leaves Infected by Potato virus A and Potato virus Y显示文摘 | H. Ry?lavá K. Müller ?. Semorádová H. Synková N. ?e?ovská | 2003 | Photosynthetica2003，，3： | 1 |
| 20 | No difference in the proportion of insulin receptor exon 11 +/- isoform mRNA in the liver of rats after development of hypertension显示文摘 | Lou Y Zee RY Li M | 1996 | Clin Exp Pharmacol Physiol1996，23，67： | 1 |
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