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| 1 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 2 | Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer显示文摘 | Stephanie Hille Daniel T. Rein Marion Riffelmann Rainer Neumann Judith Sartorius Andreas Pfützner Christian M. Kurbacher Thomas Sch?ndorf Martina Breidenbach | 2006 | Anti-Cancer Drugs2006，，9： | 1 |
| 3 | Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders显示文摘 | Caroline Nothdurfter Thomas C. Baghai Cornelius Schüle Rainer Rupprecht | 2012 | European Archives of Psychiatry and Clinical Neuroscience2012，，2： | 1 |
| 4 | Opportunities and Challenges of Spray Forming High-alloyed Steels显示文摘 | Alwin Schulz Volker Uhlenwinkel Christoph Escher Rainer Kohlmann Alfred Kulmburg Mafia Carmen Montero Roland Rabitsch Wolfgang Sch'utzenhofer Domenico Stocchi Dominique Viale | 2008 | Materials Science and Engineering A2008，477，1： | 1 |
| 5 | Detection of patients with coronary artery disease using cardiac magnetic field mapping at rest显示文摘 | Andrej Gapelyuk Niels Wessel Robert Fischer Udo Zacharzowsky Lydia Koch Daniela Selbig Henry Schütt Bianca Sawitzki Friedrich C. Luft Rainer Dietz Alexander Schirdewan | 2007 | Journal of Electrocardiology2007，，5： | 1 |
| 6 | A note on the valuation of risky corporate bonds显示文摘 | Sch?bel Rainer Schobel | 1999 | OR Spektrum1999，，21： | 1 |
| 7 | Monoclonal Antibodies against the Human Somatostatin Receptor Subtypes 1-5: Development and Immunohistochemical Application in Neuroendocrine Tumors显示文摘 | Schmid Herbert A Lambertini Chiara Van Vugt Harmke H Barzaghi-rinaudo Patrizia Sch?fer Judith Hillenbrand Rainer Sailer Andreas W Kaufmann Martina Nuciforo Paolo | 2012 | Neuroendocrinology2012，，： | 1 |
| 8 | Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages显示文摘 | Nadja Sch?ler Eike Zimmermann Ulrike Katzfey Helmut Hahn Rainer H Müller Oliver Liesenfeld | 2000 | International Journal of Pharmaceutics2000，，2： | 1 |
| 9 | Endogenous brain protection by granulocyte-colony stimulating factor after ischemic stroke显示文摘 | Sevgi Sevimli Kai Diederich Jan-Kolja Strecker Matthias Schilling Rainer Klocke Sigrid Nikol Friederike Kirsch Armin Schneider Wolf-Rüdiger Sch?bitz | 2009 | Experimental Neurology2009，，2： | 1 |
| 10 | The dynamics of oxygen concentration, pH value, and organic acids in the rhizosphere of Juncus spp.显示文摘 | Stephan Blossfeld Dirk Gansert Bj?rn Thiele Arnd J. Kuhn Rainer L?sch | 2011 | Soil Biology and Biochemistry2011，，6： | 1 |
| 11 | The relationship between juxtapapillary duodenal diverticula and biliary stone disease显示文摘 | Gottfried Novacek Michael Walgram Peter Bauer Rainer Sch?fl Alfred Gangl Regina P?tzi | 1997 | European Journal of Gastroenterology & Hepatology1997，，4： | 1 |
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