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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Skin-gut axis:The relationship between intestinal bacteria and skin health显示文摘The gut microbiome is an emerging area of interest in medicine. Imbalances in the gut microbiome have been linked to a number of disease states such as obesity and type 2 diabetes. The relationship between normally residing intestinal bacteria(the gut microbiota) and their potential role in the pathogenesis of skin diseases is an area of research for which we are only beginning to understand. Small studies have demonstrated underlying changes in the gut microbiome of patients with certain dermatological diseases. Interestingly, studies suggest that probiotics may have a role in the treatment of atopic dermatitis. However, the concept of the 'skin-gut axis' is a newly emerging and important avenue of investigation, still lacking in pathobiological explanations. This review will introduce and describe the intestinal microbiome as it relates to skin health in a complex communication network between the immune system, endocrine system, metabolic system, and nervous system. | Alexandra R Vaughn Manisha Notay Ashley K Clark Raja K Sivamani | 2017 | World Journal of Dermatology2017，6，4： | 4 |
| 3 | Malnutrition screening in hospitalised patients and its implication on reimbursement显示文摘 | Raja R Lim AV Lim YP | 2004 | Intern Med J2004，34，4： | 1 |
| 4 | Influence of Magnetic Field on the Performance of Bubble Columns and Airlift Bioreactor with Submersed Microorganisms 显示文摘 | Raja R T B M L Sonolikar R L Saheb S P | 1997 | Chemical Engineering Science1997，5，2021： | 1 |
| 5 | Solvent extraction of Hf(IV) from acidic chloride solutions using Cyanex 302显示文摘 | REDDY B R KUMAR J R RAJA K P REDDY A V | 2004 | Minerals Engineering2004，17，： | 1 |
| 6 | Clinical significance of mi- crometastases detection in lymph nodes from head and neck squamous ceil carcinoma 显示文摘 | Ferris R Xi L Raja S | 2008 | Otolaryngol Head Neck Surg2008，139，3： | 1 |
| 7 | Reconstruction of finger tip amputations with advan- cement flap and free nail bed graft 显示文摘 | Raja sabapathy S Yenkatramani H Bharathi R | 2002 | J Hand Surg Br2002，27，2： | 1 |
| 8 | Pneumococcal antimicro-bial resistance:therapeutic strategy and management in community-acquired pneumonia显示文摘 | Aspa J Rajas O de Castro F R | 2008 | Expert Opin Pharmacother2008，9，2： | 1 |
| 9 | Accurate and reproducible gene expression profiles from laser capture microdissection transcript amplification, and high density oligonucleotide microarray analysis 显示文摘 | LUZZI V MAHADEVAPPA M RAJA R | 2003 | J Mol Diagn2003，5，1： | 1 |
| 10 | Vanadium market in the world 显示文摘 | Raja B V R | 2007 | Steelworld2007，13，2： | 1 |
| 11 | Molecular sieve catalysts for the regioselective and shape selective oxyfunctionalization of alkanes in air 显示文摘 | Thomas J M Raja R Sankar G | 2001 | Acc Chem Res2001，34，3： | 1 |
| 12 | Comparison of the 2010 American College of Rheumatology/European League Against Rheuma-tism and the 1987 American Rheumatism Association classification cri-teria for rheumatoid arthritis in an early arthritis cohort in New Zealand 显示文摘 | Raja R Chapman PT ODonnell JL | 2012 | J Rheumatol2012，39，11： | 1 |
| 13 | Identification polypeptide biomarkers of porcine skin gelatin by two-dimensional electrophoresis显示文摘 | Aina M A Amin I Raja Mohd Hafidz R N | | 0，，03： | 1 |
| 14 | Microalgae: a sustainable feed source for aquaculture 显示文摘 | Hemaiswarya S Raja R Kumar R R | 2011 | World Journal of Microbiology and Biotechnology2011，27，8： | 1 |
| 15 | Exploitation of Dunaliella for β-carotene production显示文摘 | RAJA R HEMAISWARYA S RENGASAMY R | 2007 | Applied Microbiology Biotechnology2007，74，： | 1 |
| 16 | Towards an environmentally acceptable heterogeneous catalytic method of producing adipic acid by the oxidation of hydrocartions in air显示文摘 | Raja R Lee S O Sanchez M | 2002 | Topics in Catalysis2002，20，14： | 1 |
| 17 | Engineering Education in India-Quality Concerns and Remedial Measures 显示文摘 | R V RAJA KUMAR | 2007 | The Journal of Technical Education2007，30，3： | 1 |
| 18 | Global Exponential Stability of BAM Neural Networks with Time-varying Delays:The Discrete-time Case显示文摘 | Raja R Anthoni S M | 2011 | Commun Nonlinear Sci Numer Simulat2011，16，： | 1 |
| 19 | Molecular sieve catalysts for the regioselective and shape se- lective oxyfunctionalization of alkanes in air显示文摘 | THOMAS J M RAJA R SANKAR G | 2001 | Acc Chem Res2001，34，3： | 1 |
| 20 | Redox solid catalysts for the selective oxidation of cyclohexane in air显示文摘 | SANKAR G RAJA R THOMAS J M | 1998 | Catalysis Letters1998，55，： | 1 |
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