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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 2 | A TEM study of microstructural changes during retrogression and reaging in 7075 aluminium alloy 显示文摘 | Danh N C Rajan K Wallance W | 1983 | Metall Trans A1983，14，7： | 2 |
| 3 | Microstructural study of a high-strength stress-corrosion resistant 7075 aluminum alloy 显示文摘 | Rajan K Wallance R S Beddoes J C | 1982 | J Mater Sci1982，17，10： | 2 |
| 4 | Transumbilical flexible endoscopic cholecystectomy in humans:first feasibility study using a hybrid technique显示文摘 | Palanivelu C Rajan PS Rangarajan M | 2008 | Endoscopy2008，40，5： | 1 |
| 5 | Banks as liquidity pr oviders: An explanation for the co-existence of lending and deposit taking 显示文摘 | Kashy A K Rajan R Stein J C | 2002 | Journal of Finance2002，57，1： | 1 |
| 6 | Effect of exogenous keratinocyte growth factor on corneal epithelial migration after photorefractive keratectomy显示文摘 | Rajan M S Shafiei S Mohrenfels C V | 2004 | J Cataract Refract Stag2004，30，10： | 1 |
| 7 | Two-phase anaerobic digestion of water hyacinth or urban garbage显示文摘 | CHANAKYA H N BORGAON KARS RAJAN M G C | 1992 | Bioresource Technology1992，42，： | 1 |
| 8 | Laparoscopic cholecystectomy in cirrhotic patients:the role of subtotal cholecystectomy and its variants显示文摘 | Palanivelu C Rajan PS Jani K | | 0，，： | 1 |
| 9 | Transumbilical flexible endoscopic eholeeystectomy in humans:first feasibility study using a hybrid technique 显示文摘 | Palanivelu C Rajan PS Rangarajan M | 2008 | Endoscopy2008，40，5： | 1 |
| 10 | Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion 显示文摘 | Lakka SS Rajan M Condi C | 2002 | Oncogene2002，21，5： | 1 |
| 11 | The choice of performance measures in annual bonus contracts 显示文摘 | Ittner C D Larcker D F and Rajan M V | 1997 | The Accounting Review1997，72，2： | 1 |
| 12 | Evolution in techniques of laparoscopic pancreaticoduodenectomy : a decade long ex- perience from a tertiary center显示文摘 | Palanivelu C Rajan PS Rangarajan M | 2009 | J Hepatobiliary Pancreat Surg2009，16，6： | 1 |
| 13 | The summer monsoon onset process over south Asia and an objective method for the data of monsoon onset over Kerala显示文摘 | JOSEOH P V SOORAJ K P RAJAN C K | 2006 | Int J Clim2006，26，： | 1 |
| 14 | Microstructural Study of A High-Strength Stress-Corrosion Resistant 7075 Aluminum Alloy显示文摘 | Rajan K Wallace W Beddoes J C | 1982 | J Mater Sci1982，17，10： | 1 |
| 15 | Fuzzy approach for short term load forecasting显示文摘 | Pandian S C Duraiswamy K Rajan C C A | 2006 | Electric Power Systems Research2006，76，67： | 1 |
| 16 | Transumbilical flexible endoscopic cholecystectomy in humans:first feasibility study using a hybrid techni显示文摘 | Palanivelu C Rajan PS Rangarajan M | 2008 | Endoscopy2008，40，5： | 1 |
| 17 | Laparoscopic cholecystectomy in cirrhotic patients: The role of subtotal cholecystectomy and its variants 显示文摘 | Palanivelu C Rajan PS Jani K | 2006 | J Am Coll Surg2006，203，： | 1 |
| 18 | Refractive change in duced by the LASIK flap in a biomechanieal finite element model显示文摘 | Deenadayalu C Mobasher B Rajan SD | 2006 | J Refract Surg2006，22，3： | 1 |
| 19 | Block copolymers of telechelic poly (phenylene sulfide) and semiaromatic thermotropic liquid crystalline polyester segments 显示文摘 | Gopakumar T G Ponrathnam S Rajan C R | 1998 | Joumal of Polymer Science Part A: Polymer Chemistry1998，36，15： | 1 |
| 20 | An evolutionary programming-based tabu search method for solving the unit commitment problem显示文摘 | Christober Asir Rajan C Mohan M R | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
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