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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Copper isotope ratios in magmatic and hydrothermal ore-forming environments显示文摘 | Peter B Larson Kierran Maher Frank C Ramos Zhaoshan Chang Miguel Gaspar Lawrence D Meinert | 2003 | Chemical Geology2003，，3： | 1 |
| 3 | Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex显示文摘 | Weisberg M P Ramos M S | 2001 | Neuropharmacology2001，41，6： | 1 |
| 4 | Char- acterization and dehydrogenation activity of Pt/Nb2 05 catalysts显示文摘 | Aranda D A G Ramos A L D Passos F B | 1996 | Catalysis Today1996，28，12： | 1 |
| 5 | Monitoring azospirillum-wheat interactions using the gfp and gusA genes constitutively expressed from a new broad-host range vector显示文摘 | RAMOS H J O RONCATO L D B SOUZA E M | 2002 | J Biotech2002，97，： | 1 |
| 6 | Age at diagnosis and quality of life in breast cancer survivors 显示文摘 | Cimprich B Ronis D L Martinez Ramos G | 2002 | Cancer Pract2002，10，2： | 1 |
| 7 | Early neuropathology of somatostatin/NPY GABAergie cells in the hippocampus of a PSlxAPP transgenie model of Alzheimer' s disease 显示文摘 | Ramos B Baglietto -Vargas D del Rio JC | 2006 | Neurobiol Ag- ing2006，27，11： | 1 |
| 8 | Risk factors for work-related musculo- skeletal disorders: A systematic review of recent longitudinal studies 显示文摘 | Costa B R D Edgar Ramos V | 2010 | American Journal of Industrial Medicine2010，53，3： | 1 |
| 9 | Hydrocarbon selective catalytic reduction of NO over Cu/Fe-pillared clays: Diffuse refectance infrared spectroscopy studies显示文摘 | DORADO F GARCFA P B LUCAS A D RAMOS M J ROMERO A | 2010 | J Mol Catal A2010，332，12： | 1 |
| 10 | Monitoring Azospirillum-wheat interactions using the gfp and gus A genes constitutively expressed from a new broad-host range vector 显示文摘 | Ramos H J O Roncato-Maccari L D B Souza E M | 2002 | Biotechnol2002，97，3： | 1 |
| 11 | The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function显示文摘 | RAMOS P MARTINEZ B | 2006 | Genes Chromosomes Cancer2006，45，2： | 1 |
| 12 | NF-zB in renal inflammation 显示文摘 | Sanz A B Sanchez-Nino M D Ramos A M | 2010 | JAm Soc Nephrol2010，21，8： | 1 |
| 13 | Disease control in philippine carabao mango with preharvest bagging and postharvest hot water treatment显示文摘 | BUGANIC JR R D LIZADA M C C DE RAMOS M B | 1997 | Acta Horticulture1997，455，： | 1 |
| 14 | Production of monoclonal antibodies for immunoaffinity purification and quantitation of Blot 1 allergen in mite and dust extracts显示文摘 | Ramos J D Teo A S Lee B W | 2004 | Clin Exp Allergy2004，34，4： | 1 |
| 15 | Viral activation and recruitment of metacaspases in the unicellular coccolithophore, Emiliania huxleyi 显示文摘 | Bidle K D Haramaty L Ramos J B | 2007 | PNAS2007，104，14： | 1 |
| 16 | NF-kappaB in renal inflammation显示文摘 | Sanz A B Sanchez-Nino M D Ramos A M | | 0，，08： | 1 |
| 17 | Thl and Th17 hypercytokinemia as early host response signature in severe pandemic influenza 显示文摘 | Bermejo-Martin JF Ortiz de Lejarazu R Pumarola T Rello J Almansa R Ramirez P Martin-Loeches I Varillas D Gallegos MC Seran C Micheloud D Gomez JM Tenorio-Abreu A Ramos MJ Molina ML Huidobro S Sanchez E Gorden M Fernandez V del Castillo A Marcos MA Villanueva B Lopez C J Rodriguez-Dominguez M Galan JC Canton R Lietor A Rojo S Eiros JM Hinojosa C Gonzalez I Torner N Banner D Leon A Cuesta P Rowe T Kelvin DJ | 2009 | Crit Care2009，13，6： | 1 |
| 18 | Copper isotope ratios in magmatie and hydrothermal ore-forming environments 显示文摘 | Larson P B Maher K Ramos F C Chang Z Gaspar M Meinert L D | 2003 | Chern Geol2003，201，： | 1 |
| 19 | Copper isotope ratios in magmatic and hydrothermal ore-forming environments 显示文摘 | Larson P B Maher K Ramos F C Chang Z S Gaspar M Meinert L D | 2003 | Chemical Geology2003，201，： | 1 |
| 20 | NF- kappaB in renal inflammation显示文摘 | SANZ A B SANCHEZ NllqO M D RAMOS A M | 2010 | J Am Soc Nephrol2010，21，8： | 1 |
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