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| 1 | Tissue differential expression of lycopene β-cyclase gene in papaya显示文摘Carotene pigments in flowers and fruits are distinct features related to fitness advantages such as attracting insects forpollination and birds for seed dispersal.In papaya,the flesh color of the fruit is considered a quality trait that correlateswith nutritional value and is linked to shelf-life of the fruit.To elucidate the carotenoid biosynthesis pathway in papaya,we took a candidate gene approach to clone the lycopene β-cyclase gene,LCY-B.A papaya LCY-B ortholog,cpLCY-B,was successfully identified from both cDNA and bacterial artificial chromosome(BAC)libraries and complete genomicsequence was obtained from the positive BAC including the promoter region.This cpLCY-B shared 80% amino acididentity with citrus LCY-B.However,full genomic sequences from both yellow- and red-fleshed papaya were identical.Quantitative real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth yellow-and red-fleshed genotypes.Further expression analyses of cpLCY-B showed that its expression levels wereseven- and three-fold higher in leaves and,respectively,flowers than in fruits,suggesting that cpLCY-B is down-regulatedduring the fruit ripening process. | Rachel L Skelton Qingyi Yu Rajeswari Srinivasan Richard Manshardt Paul H Moore Ray Ming | 2006 | Cell Research2006，16，8： | 8 |
| 2 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 3 | Housing price diffusion patterns at different aggregation levels: An examination of housing market efficiency 显示文摘 | Pollakowski H O Ray T S | 1997 | J Housing Res1997，8，1： | 1 |
| 4 | Early effects of hypoxia/reoxygenation on VEGF,ANG-1,ANG-2 and their receptors in the rat myocardium:implications for myocardial angiogenasis显示文摘 | Ray PS Estrada-Hernandez T Sasaki H | 2000 | Mol Cell Biochem2000，213，： | 1 |
| 5 | EEG alpha activity reflects attentional demands,and beta activity reflects emotional and cognitive processes显示文摘 | RAY W J COLE H W | 1985 | Science1985，228，4700： | 1 |
| 6 | Early effect of hypoxia/reoxygenation on VEGF,Ang-1,Ang-2 and their receptor in the rat myocardium:implications for myocardium angiogenesis显示文摘 | Ray PS Estrada-Hermandez T Sasaki H | 2000 | Mol Cell Biochem2000，213，12： | 1 |
| 7 | Measurements and correlations of the physical of CO_Wheavy crude oil mixtures显示文摘 | Chung Frank T H Jones Ray A Nguyen Hai T | 1988 | SPE Reservoir Engi- neering1988，40，8： | 1 |
| 8 | Analysis of heat transfer in simultaneously developing pulsating laminar flow in a pipe with constant wall temperature显示文摘 | Chattopadhyay H Durst F Ray S | 2006 | International Communications in Heat and Mass Transfer2006，33，4： | 1 |
| 9 | Delayed arteriovenous fistula and pseudoaneurysm after an open tibial fracture successfully managed with selective angiographic embolization 显示文摘 | Wolford H Peterson SL Ray C | 2001 | J Trauma2001，51，： | 1 |
| 10 | Direct electron transfer of gluc - ose oxidase on carbon nanotubes 显示文摘 | Anthony Guiseppi - Elie Chenghong Lei Ray H Baugh man | 2002 | Nanotechnology2002，13，： | 1 |
| 11 | Effects of methionine hydroxy analog on milk secretion and ruminal and blood variables of dairy cows fed a low fiber diet显示文摘 | Ray S R Croom W J Rakes A H | 1983 | J Dairy Sci1983，66，： | 1 |
| 12 | Changes in sleep-wakefulness in the medial preoptic area lesioned rats:role of thermal preference显示文摘 | Ray B Mallick H N Kumar V M | 2005 | Behav Brain Res2005，158，1： | 1 |
| 13 | Species diversity and the scale of the landscape mosaic:do scale of movement and patch size affect diversity?显示文摘 | Debinski D M Ray C Saveraid H | 2001 | Biological Conservation2001，，98： | 1 |
| 14 | Fusarium dry rot显示文摘 | Phillip W Ray H William K | 2007 | Michigan Potato Diseases Extension Bulletin2007，，： | 1 |
| 15 | The IL-6 trans-signaling-STAT3 path-way mediates ECM and cellular proliferation in fibroblasts fromhypertrophic scar显示文摘 | Ray S Ju X Sun H | 2013 | J Invest Dermatol2013，133，5： | 1 |
| 16 | The effect of cement composi- tion and pH of environment of sulfate resistance of portland ce- ments and blended cements显示文摘 | CAO H T BUCEA L RAY A | 1997 | Cement and Concrete Composites1997，19，2： | 1 |
| 17 | A study of the impact of machine tool structure on machining processes显示文摘 | CHANAL H DUC E RAY P | 2006 | International Journal of Machine Tools & Manufacture2006，46，2： | 1 |
| 18 | The RSK factors of activating the Ras/MAPK signaling cascade显示文摘 | Carriere A Ray H Blenis J | 2008 | Front Biosci2008，13，10： | 1 |
| 19 | Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex显示文摘 | RAY H SUAU F VINCENT A | 2009 | Biochem Biophys Res Commun2009，378，3： | 1 |
| 20 | Intrusion Detection Techniques and Approachcs显示文摘 | THEUNS V RAY H | 2002 | Computer Communications2002，25，： | 1 |
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