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| 1 | Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion显示文摘Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the lungs.However,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPME)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key metabolites.The in vivo Bio-SPME-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical trial.Two patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h IVLP.In both pig and human cases,DOX tissue levels presented similar trends during IVLP.Human lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP procedure.In addition to DOX levels,Bio-SPME followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug administration.Real-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPME chemical biopsy approach.Bio-SPME also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy. | Barbara Bojko Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro Reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios Marcos Tascon Krzysztof Gorynski Marcelo Cypel Janusz Pawliszyn | 2021 | Journal of Pharmaceutical Analysis2021，11，1： | 3 |
| 2 | An evidence-based review of the incidence of CNS bleeding with anti-VEGF therapy in non- small cell lung cancer patients with brain metastases显示文摘 | Sandier A Hirsh V Reck M | 2012 | Lung Cancer2012，78，1： | 1 |
| 3 | Calcium absorbability from milk products, an imitation milk and calcium carbonate显示文摘 | RECKE R BAMNI A BARGER-LUX M J | 1988 | J Clini Nutr1988，47，： | 1 |
| 4 | Ipilimumab in combination with paclitaxeland carboplatin as first-line therapy in extensive-dis- ease-small-cell lung cancer: results from a randomized, double- blind, multicenter phase 2 trial显示文摘 | Reck M Bondarenko I Luft A | 2013 | Ann Oncol2013，24，1： | 1 |
| 5 | Hyponatremia as prognostic factor in small cell lung cancer - A retro- spective single institution analysis 显示文摘 | Hermes A Waschki B Reck M | 2012 | Respir Med2012，106，6： | 1 |
| 6 | Ipilimumab in combination with pac litaxel and carboplatin as first-line therapy in extensive- disease-small-cell lung cancer:, results from a randomized, double-blind, multicenter phase 2 trial显示文摘 | Reck M Bondarenko I Luft A | 2013 | Ann Oncol2013，24，1： | 1 |
| 7 | Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non- small-cell lung cancer ( LUME-Lung 1 ) : a phase 3, double-blind, randomised controlled trial显示文摘 | Reck M Kaiser R Mellemgaard A | 2014 | Lancet Oncol2014，15，2： | 1 |
| 8 | Estimation of the effect of salmon calcitonin in established osteo- porosis by biochemical bone markers 显示文摘 | NIELSEN N M VON DER RECKE P HANSEN M A | 1994 | Calcif Tissue Int1994，55，1： | 1 |
| 9 | IgE autoantibodies against the intracellular domain of BP180显示文摘 | Dresow SK Sitaru C Recke A | | 0，，02： | 1 |
| 10 | Mechanics of minor ship collisions显示文摘 | Recking K A | 1983 | International Journal of Impact Engineering1983，1，3： | 1 |
| 11 | Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patient with severe sepsis显示文摘 | SCHROEDER S RECK M HOEFT A | 1999 | Crit Care Med1999，27，： | 1 |
| 12 | Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non- small cell lung cancer ( LUNE-Lung 1 ) : a phase 3, double-blind, randomised controlled trial显示文摘 | Reck M Kaiser R Mellemgaard A | 2014 | Lancet Oncol2014，15，2： | 1 |
| 13 | Systematic review and meta-analysis of randomised, phase 11/m trials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-small- cell lung cancer显示文摘 | Soria JC Mauguen A Reck M | 2013 | Ann Onco12013，24，1： | 1 |
| 14 | The natural course of radiographic progression in ankylosing spondylitis:differences between genders and appearance of characteristic radiographic features显示文摘 | Baraliakos X Listing J von der Recke A | 2011 | Curr Rheumatol Rep2011，13，5： | 1 |
| 15 | Anti-angiogenic-speeific adverse events in patients with non-small cell lung cancer treated with nintedanib and docetaxel 显示文摘 | Reck M Mellemgaard A von Pawel J | 2015 | Lung Cancer2015，90，2： | 1 |
| 16 | The natural course of radiographic progression in ankylosing spondylitis--evidence for major individual variations in a large proportion of patients显示文摘 | Baraliakos X Listing J von der Recke A | | 0，，05： | 1 |
| 17 | Hyponatremia as prog- nostic factor in small cell lung cancer--a retrospective sin- gle institution analysis 显示文摘 | Hermes A Waschki B Reck M | | Respir Med0，106，6： | 1 |
| 18 | Comparison of global climate change simulations for 2 x CO2 - induced warming: an intercomparison of 108 temperature change projections published between 1980 and 1995 显示文摘 | KACHOLIA K RECK R A | 1997 | Journal of Climate Change1997，35，1： | 1 |
| 19 | Electrofor-mation of giant phospholipid vesicles on a silicon substrate:advantages of controllable surface proper-ties 显示文摘 | Le Berre M Yamada A Reck L | 2008 | Langmuir2008，24，6： | 1 |
| 20 | Systematic review and meta-analysis of randomised,phaseⅠ/Ⅰtrials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-smallcell lung cancer显示文摘 | Soria JC Mauguen A Reck M | 2013 | Ann Oncol2013，24，1： | 1 |
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