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| 1 | Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach显示文摘AIM: To evaluate the ability of Curcuma longa (CL) and Tinospora cordifolia (TC) formulation to prevent anti-tuberculosis (TB) treatment (ATT) induced hepatotoxicity. METHODS: Patients with active TB diagnosis were randomized to a drug control group and a trial group on drugs plus an herbal formulation. Isoniazid, rifampicin, pyrazinamide and ethambutol for first 2 mo followed by continuation phase therapy excluding Pyrazinamide for 4 mo comprised the anti-tuberculous treatment. Curcumin enriched (25%) CL and a hydro-ethanolic extract enriched (50%) TC 1 g each divided in two doses comprised the herbal adjuvant. Hemogram, bilirubin and liver enzymes were tested initially and monthly till the end of study to evaluate the result. RESULTS: Incidence and severity of hepatotoxicity was significantly lower in trial group (incidence: 27/192 vs 2/316, P < 0.0001). Mean aspartate transaminase (AST) (195.93 ± 108.74 vs 85 ± 4.24, P < 0.0001), alanine transaminase (ALT) (75.74 ± 26.54 vs 41 ± 1.41, P < 0.0001) and serum bilirubin (5.4 ± 3.38 vs 1.5 ± 0.42, P < 0.0001). A lesser sputum positivity ratio at the end of 4 wk (10/67 vs 4/137, P = 0.0068) and decreased incidence of poorly resolved parenchymal lesion at the end of the treatment (9/152 vs 2/278, P= 0.0037) was observed. Improved patient compliance was indicated by nil drop-out in trial vs 10/192 in control group (P < 0.0001). CONCLUSION: The herbal formulation prevented hepatotoxicity significantly and improved the disease outcome as well as patient compliance without any toxicity or side effects. | Meghna R Adhvaryu Narsimha M Reddy Bhasker C Vakharia | 2008 | World Journal of Gastroenterology2008，14，30： | 13 |
| 2 | Fast RCS Computation over a Frequency Band Using Method of Moments in Conjunction with Asymptotic Waveform Evaluation Technique显示文摘 | Reddy C J Deshpande M D Cockrell C R | 1998 | IEEE Trans on Antennas and Propagation1998，46，8： | 1 |
| 3 | An overview of the relationships between solutions of the classical and shear deformation plate theories显示文摘 | Reddy J N Wang C M | 2000 | Composites Science and Technology2000，60，1213： | 1 |
| 4 | Induced systemic pro-tection against tomato late blight elicited by plant growth-promoting rhizobacteria显示文摘 | Yan Z N Reddy M S Ryu C M | | 0，，12： | 1 |
| 5 | Carbon and chlorine isotope effects during abiotic reductive dechlorination of polychlorinated ethanes 显示文摘 | Hofstetter T B Reddy C M Heraty L J | 2007 | Environ Sci Technol2007，41，13： | 1 |
| 6 | Method for Rapid Localization of Seafloor Petroleum Contamination Using Concurrent Mass Spectrometry and Acoustic Positioning 显示文摘 | Camilli R Bingham B Reddy C M | 2009 | Marine Pollution Bulletin2009，，58： | 1 |
| 7 | Determination of metmyoglobin reductase activity in bovine skeletal muscles显示文摘 | Reddy I M Carpenter C E | 1991 | Journal of Food Science1991，56，： | 1 |
| 8 | Buckling load relationship between Reddy and Kirchhoff plates of polygonal shape with simply supported edges显示文摘 | Wang C M Reddy J N | 1997 | Mechanics Research Communications1997，24，1： | 1 |
| 9 | Chemistry and biology of diazonamide A: Second total synthesis and biological investigations显示文摘 | Nicolaou K C Hao J Reddy M V | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 10 | Buckling load relationship between Reddy and Kirchhoff plates of polygonal shape with simply supported edges显示文摘 | Wang C M Reddy J N | 1997 | Mechanics Research Communications1997，24，： | 1 |
| 11 | Different signaling pathways of induced resistance by rhizobacteria in Arabi- dopsis thaliana against two pathovars of Pseudomonas sy- ringae 显示文摘 | Ryu C M Hu C H Reddy M S | 2003 | New Phytologist2003，160，： | 1 |
| 12 | Evaluation of extraction and purification methods for obtaining PCR amplifiable DNA from compost for microbial community analysis显示文摘 | La Montagne M G Holden P A Reddy C A | 2002 | Microbiol Methods2002，49，3： | 1 |
| 13 | Relationship between vibration frequencies of Reddy and Kirchhoff polygonal plates with simply supported edges显示文摘 | Wang C M Kitipornchai S Reddy J N | 2000 | ASME Journal of Vibration and Acoustics2000，122，： | 1 |
| 14 | Radiocarbon content of synthetic and natural semi-volatile halogenated organic com- pounds显示文摘 | REDDY C M XU L EGLINTON T I | 2002 | Environmental Pollution2002，120，2： | 1 |
| 15 | Isolation of laccase gene - specific sequences from white rot and brown rot fungi by PCR显示文摘 | D' Souza T M Boominathan K Reddy C A | 1996 | Applied and Environmental Microbiology1996，62，10： | 1 |
| 16 | 显示文摘 | Reddy K M Song C | 1996 | Catal Today1996，31，： | 1 |
| 17 | Stable chlorine isotopic compositions of Aroclors and Aroclor-eontaminated sediments显示文摘 | Reddy C M Heraty L J Holt B D | 2000 | Environmental Science and Technology2000，34，： | 1 |
| 18 | Evaluation of antimicrohial peptide nisin as a safe vaginal contraceptive agent in rabbits:in vitro and in vivo studies显示文摘 | REDDY K V R ARANHA C GUPTA S M | 2004 | Reproduction2004，128，1： | 1 |
| 19 | Atmospheric optical and radiative effects of anthropogenic aerosol constituents from India显示文摘 | REDDY M S VENKATARAMAN C | 2000 | Atmospheric Environment2000，34，： | 1 |
| 20 | Relationship between vibration frequencies of Reddy and Kirchhoff polygonal plates with simply supported edges显示文摘 | Wang C M Kitipornchai S Reddy J N | 2000 | ASME Journal of Vibration and Acoustics2000，122，1： | 1 |
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