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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | A tran sient two-dimensional finite volume model for the simulation of vertical U-tube ground heat exchanges 显示文摘 | YAVUZTURK C SPLITLER J D REES S J | 1999 | ASHRAE Transactions1999，105，2： | 1 |
| 3 | Animal models of diabetes mellitus 显示文摘 | Rees D A Alcolado J C | 2005 | Diabet Med2005，22，4： | 1 |
| 4 | Temporal variability of denitrification in estuarine sediments显示文摘 | LAW C S REES A P OWENS N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 5 | One-pot synthesis of tetrasubstituted pyrazoles-proof of regiochemistry 显示文摘 | HANEFELD U REES C W WHITE A J P | 1996 | J Chem Soc Perkin Trans 11996，13，： | 1 |
| 6 | Crade 3 ischemia on the admission electrocardiogram is associated with severe microvascular injury on cardiac mannetic resonance imaging after sl elevation myocardial infarction显示文摘 | WEAYER J C REES D PRASAN A M | 2011 | J Electro- cardiol2011，44，1： | 1 |
| 7 | Nitrous oxide: Estuarine sources and atmospheric flux 显示文摘 | LAW C S REES A P OWENS N J P | 1992 | Estuarine Coastal and Shelf Science1992，35，3： | 1 |
| 8 | A survey of standing column well installations in North America 显示文摘 | ORIO C D JOHNSON C N REES S J | 2005 | ASHRAE Transactions2005，111，2： | 1 |
| 9 | Crystallographic structure and functional implications of the nitrogenase molybdenum-iron protein from Azotobacter vinelandii 显示文摘 | Kin J Rees D C | 1992 | Nature1992，360，： | 1 |
| 10 | A transient two-dimensional finite volume model for the simulation of vertical U-tube ground heat exchanges显示文摘 | Yavuzturk C Splitler J D Rees S J | 1999 | ASHRAE Transaction1999，105，2： | 1 |
| 11 | Structural models for the metal centers in the nitrogenase molybdenum-iron protein 显示文摘 | Kim J Rees D C | 1992 | Science1992，257，： | 1 |
| 12 | Sexual function in men and women with neurological disorders 显示文摘 | Rees PM Fowler C J Maas CP | 2007 | Lancet2007，369，9560： | 1 |
| 13 | Management of complex colon- ic polyps in the English Bowel Cancer Screening Programme显示文摘 | Lee TJ Rees C J Nickerson C | 2013 | Br J Surg2013，100，12： | 1 |
| 14 | Studies of diffusion and flow by pulsed NMR techniques显示文摘 | Packer K J Rees C Tomlinson D J | 1972 | Advances in Molecular Relaxation Processes1972，3，14： | 1 |
| 15 | p57kip2 immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy显示文摘 | Sebire N J Rees H C Peston D | 2004 | Histopathology2004，45，2： | 1 |
| 16 | Acupuncture for chronic headache in primary care: large, pragmatic, randomised trial 显示文摘 | Vickers A J Rees R W Zollman C E | 2004 | BMJ2004，328，7442： | 1 |
| 17 | Animal models of diabetes mellitus 显示文摘 | Rees D A Alcoado J C | 2005 | Diabetic Medicine2005，22，： | 1 |
| 18 | Expanding applications for the microdebrider in pediatric endo scopic airway surgery 显示文摘 | REES C J TRIDICO T I KIRSE D J | 2005 | Otolaryngol Head Neck Surg2005，133，： | 1 |
| 19 | A transient two-dimensionalfinite volume model for the simulation of vertical U-tube ground heat exchangers显示文摘 | YAVUZTURK C SPITLER J D REE S J | 1999 | ASHRAE Transactions1999，105，2： | 1 |
| 20 | Animal models of diabetes mellitus显示文摘 | Rees D A Alcolado J C | 2005 | Diabet Med2005，22，： | 1 |
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