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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 3 | Acute gouty synovitis associated with 'urate milk' 显示文摘 | FAM A G REIS M D SZALAI J P | 1997 | J Rheumatol1997，24，12： | 1 |
| 4 | Analysis of the sealing ability of different obturation techniques in oval-shaped canals:a study using a bacterial leakage model显示文摘 | De Deus G Murad CF Reis CM | 2006 | Braz Oral Res2006，20，1： | 1 |
| 5 | Vanadium oxide nanostructures derived from a novel vanadium(Ⅳ) alkoxide precursor显示文摘 | Willian G Menezes Dayane M Reis | 2007 | Chem Phys Lett2007，445，46： | 1 |
| 6 | Integrated transport and reaction in an ion exchange membrane bioreactor 显示文摘 | Velizarov S Reis M A M Crespo J G | 2002 | Desali- nation2002，149，13： | 1 |
| 7 | Sticky Information Versus Sticky Prices : A Proposal to Replace the New Keynesian Phillips Curve 显示文摘 | Mankiw N G R Reis | 2002 | The Quarterly Jour- nal of Economics2002，，117： | 1 |
| 8 | Development of a rapid and specific assay for detection of busulfan in human plasma by high-performance liquid chromatography/elect rospray ionization tandem mass spectrometry显示文摘 | Dos Reis EO Vianna-Jorge R Suarez-Kurtz G | | 0，，12： | 1 |
| 9 | Experimental analy- sis of an all-optical packet router显示文摘 | Reis C Parca G Bougioukos M | 2014 | Journal of Optical Communications and Networking2014，6，7： | 1 |
| 10 | So,ware- controlled fault tolerance 显示文摘 | Reis G A Chang J Vachhar~ani N | 2005 | ACM Transactions on Architecture and Code Optimization2005，2，4： | 1 |
| 11 | Effect of spacing and age on nitrogen and phosphorus distribution in biomass of Eucalyptus camaldulensis,Eucalyptus pellita and Eucalyptus urophylla plantations in southeastern Brazil显示文摘 | Harrison R B Reis G G Reis M D G F | 2000 | Forest Ecology and Management2000，133，3： | 1 |
| 12 | Removal of trace mono-valent inorganic pollutants in an ion exchange membrane bioreactor: analysis of transport rate in a denitrification process 显示文摘 | VELIZAROV S REIS M A CRESPO J G | 2003 | Journal of Membrane Science2003，217，12： | 1 |
| 13 | Localization and pattern of expression of a female specific mRNA in Schistosoma mansoni显示文摘 | Reis M G Kuhns J Blanton R | 1989 | Mol Biochem Parasitol1989，32，： | 1 |
| 14 | Removal of tracemono-valent inorganic pollutants in an ion exchange membrane bio- reactor: Analysis of transport rate in a denitrification process 显示文摘 | Velizarov S Reis M A M Crespo J G | 2003 | Journal of Membrane Science2003，217，12： | 1 |
| 15 | Validation of a matrix solid phase dispersion (MSPD) technique for determination of pesticides in lyophilized eggs of the chicken Gallus gallus domesticus显示文摘 | dos Reis Souza M K Moreira C O de Lima T G | 2013 | Microchem J2013，110，： | 1 |
| 16 | Integrated transport and reaction in an ion exchange membrane bioreactor显示文摘 | Velizarov S Reis M A Crespo J G | 2002 | Desalination2002，149，： | 1 |
| 17 | Advances in enhanced biological phosphorus removal:from micro to macro scale显示文摘 | Oehmen A Lemos P C Carvalho G Yuan Z Kelley J Blackall L L Reis M A M | 2007 | Water Research2007，41，11： | 1 |
| 18 | Clarification and purification of aqueous Stevia extract using membrane separation process 显示文摘 | REIS M H M SILVA F V ANDRADE C M G | 2009 | Journal of Food Process Engineering2009，32，3： | 1 |
| 19 | Development and characterization of microsatellite in cucumis显示文摘 | DANIN-POLEG Y REIS N TZURI G | 2001 | Theoretical and Applied Genetics2001，102，1： | 1 |
| 20 | Growth of pruned eucalypt clone in an agroforestry system in southeastern Brazil显示文摘 | FONTAN I REIS G REIS F M | 2011 | Agroforestry Systems2011，83，2： | 1 |
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