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| 1 | Interobserver variation in histopathological assessment of Helicobacter pylori gastritis显示文摘AIM: Because the presence or absence of H pyloriinfection has important implications for therapeutic decisions based on histological assessment, the reproducibility of Sydneysystem is important. The study was designed to test the reproducibility of features of Helicobacter pylori gastritis, using the updated Sydney classification. METHODS: Gastric biopsies of 40 randomly selected cases of H pylori gastritis were scored semiquantitatively by three pathologists. Variables analysed included chronic inflammation,inflammatory activity, atrophy, intestinal metaplasia, H pylori,surface epithelial damage. k values below 0.5 represented poor, those between 0.5 and 0.75 good and values over 0.75 excellent interobserver agreement. RESULTS: The best interobserver agreement (k=0.62) was present for intestinal metaplasia. The agreement was the poorest for evaluating atrophy (k=0.31). CONCLUSION: Although the results of this study were in accordance with some previous studies, an excellent agreement could not be reached for any features of H pylori gastritis. This low degree of concordance is assumed to be due to the personal evaluation differences in grading the features, the lack of standardized diagnostic criteria, and the ignorance to reach a consensus about the methods to be used in grading the features of H pylori gastritis before initiating the study. | Ozlem Aydin Reyhan Egilmez Tuba Karabacak Arzu Kanik | 2003 | World Journal of Gastroenterology2003，9，10： | 6 |
| 2 | H pylori infection in patients with Behcet's disease显示文摘AIM:To evaluate endoscopic findings and the prevalence of H pylori in patients with Behcet's disease (BD) who have upper gastrointestinal symptoms. METHODS:The patients with BD diagnosed according to the International Study Group and followed up in the Department of Dermatology and other related departments and who had any upper gastrointestinal complaints,were included in this study. Forty-five patients with BD and 40 patients in the control group were evaluated by upper gastrointestinal endoscopy and two biopsied specimens were taken during endoscopy for H pylori . A two-week triple therapy for H pylori eradication was administered to H pylori positive patients. Two months after the treatment,the patients were evaluated by urea-breath test for eradication control. RESULTS:Patients with BD had a mean age of 36.2 ± 11.4 years (18-67 years). The mean follow-up time was 35 ± 14 mo (16-84 mo). Aphthous or deep ulcer in esophagus,stomach and duodenum had never been confirmed by endoscopic examination. Most gastric lesions were gastric erosion (40%) and the most duodenal lesions were duodenitis (17.5%) in two groups. H pylori was positive in 33 patients (73.3%) with BD. The two-week triple eradication therapy was successful in 75% of the patients. There was no difference between the groups in respect to prevalence of H pylori (73.3% vs 75%,P > 0.05),and eradication rate (75% vs 70%,P > 0.05). CONCLUSION:Endoscopic findings,eradication rate and prevalence of H pylori were similar in patients withBD and control group. | Osman Ersoy Reyhan Ersoy Ozlem Yayar Huseyin Demirci Semih Tatlican | 2007 | World Journal of Gastroenterology2007，13，21： | 3 |
| 3 | Current status of pharmacological treatment of colorectal cancer显示文摘AIM: To review the clinical trials for the development in drugs for chemotherapeutic treatment of colorectal cancer(CRC).METHODS: A systematic review identified random-ized controlled trials(RCTs) assessing drugs for the treatment of CRC or adenomatous polyps from www.clinicaltrials.gov. Various online medical databases were searched for relevant publications.RESULTS: Combination treatment regimens of stan-dard drugs with newer agents have been shown to improve overall survival, disease-free survival, time to progression and quality of life compared to that with standard drugs alone in patients with advanced colorectal cancer. The FOLFOXIRI regimen has been associated with a significantly higher response rate, progression-free survival and overall survival compared to the FOLFIRI regimen. CONCLUSION: Oxaliplatin plus intravenous bolus fluo-rouracil and leucovorin has been shown to be superiorfor disease-free survival when compared to intravenous bolus fluorouracil and leucovorin. In addition, oxaliplatin regimens were more likely to result in successful surgi-cal resections. First line treatment with cetuximab plus fluorouracil, leucovorin and irinotecan has been found to reduce the risk of metastatic progression in patients with epidermal growth factor receptor-positive colorec-tal cancer with unresectable metastases. The addition of bevacizumab has been shown to significantly in-crease overall and progression-free survival when given in combination with standard therapy. | Reyhan Akhtar Shammy Chandel Pooja Sarotra Bikash Medhi | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 3 |
| 4 | Isolation and diagnosis of Helicobacter pylori by a new method: Microcapillary culture显示文摘AIM:To investigate the performance of the microcapillary culture method(MCM) in Helicobacter pylori(H.pylori) isolation and diagnosis.METHODS:Microcapillary culture(MC),classical culture(CC),rapid urease(CLO) test,and histopathologic examination(HE) were performed with biopsy samples.Homogenized biopsy samples were loaded into capillary tubes and incubated for 48 h at 37 ℃ without providing a microaerophilic environment.Additionally,three or four loops of the homogenized sample were inoculated in a ready-to-use selective medium(Becton Dickinson,Helicobacter Agar,Modified) specific for the isolation of H.pylori and incubated at 37 ℃ in a microaerophilic atmosphere provided by Campy Gen(Becton Dickinson,Gas Pack).Bacteria reproducing in microcapillary tubes were evaluated in an inverted microscope and also were evaluated after performing a CC with the content.Results obtained by CC,CLO test,and HE were compared with those of MC.The diagnostic performances of the methods used in this study were evaluated for specificity,sensitivity,positive predictive value(PPV),negative predictive value(NPV),and CI.RESULTS:H.pylori was found positive by CLO test +HE and/or CC culture in 26 patient antrum and corpus biopsy samples.In 25(25/26) patient biopsy samples,H.pylori was isolated by MCM,whereas in only 14(14/26) patient biopsy samples,H.pylori was isolatedby CC.CLO test and HE were found positive in 17(17/26) patient biopsy samples.Comparing the results of the isolation of H.pylori by MCM,CC,CLO test,and HE,the sensitivity of the MCM was found as 96%,the specificity as 80%,the PPV as 83%,the NPV as 95%,and the 95%CI as 0.76(χ2 =31.51,P < 0.01) whereas the sensitivity of the CC was found as 54%(χ2 =19.15,P < 0.01),and the sensitivity of the CLO test and HE were found as 65%(χ2 =25.26,P < 0.01).CONCLUSION:This new microcapillary cultivation method for H.pylori has high diagnostic sensitivity compared with CC,HE,and CLO tests. | Adil M Allahverdiyev Melahat Bagirova Reyhan Caliskan Hrisi Bahar Tokman Hayat Aliyeva Gokce Unal Olga Nehir Oztel Emrah Sefik Abamor Hilal Toptas Pelin Yuksel Fatma Kalayci Mustafa Aslan Yusuf Erzin Kadir Bal Bekir S Kocazeybek | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 5 | Effect of 1%brinzolamide and 0.5%timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification显示文摘AIM:To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure(IOP)after cataract surgery.METHODS:The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens implantation.Patients scheduled for phacoemulsification were assigned to 1 of 2 groups.The treatment group received 1 drop of brinzolamide-timolol fixed combination immediately after surgery,and the control group received no treatment.The IOP was measured preoperatively and at 2h and 24h postoperatively.RESULTS:The mean IOP change was lower in the treatment group than in the control group at 2h postoperatively.The difference between the mean IOP values of the two groups at 2h postoperatively was found to be statistically significant.Twenty-four hours after the surgery,the mean IOP change was still higher in the control group when compared to the treatment group.CONCLUSION:The fixed combination brinzolamidetimolol can effectively reduce IOP after cataract surgery. | Kemal rnek Nesrin Byktortop Nurgl rnek Reyhan Ogurel Inci Elif Erbahceci Zafer Onaran | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 2 |
| 6 | Alvarado, Eskelinen, Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis显示文摘AIM:To assess the reliability and practical applicability of the widely used Alvarado,Eskelinen,Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis(RIPASA)scoring systems in patients with suspected acute appendicitis.METHODS:Patients admitted to our tertiary center due to suspected acute appendicitis constituted the study group.Patients were divided into two groups.appendicitis group(Group A)consisted of patients who underwent appendectomy and were histopathologically diagnosed with acute appendicitis,and non-appendicitis group(Group N-A)consisted of patients who underwent negative appendectomy and were diagnosed with pathologies other than appendicitis and patients that were followed non-operatively.The operative findings for the patients,the additional analyses from follow up of the patients and the results of those analyses were recorded using the follow-up forms.RESULTS:One hundred and thirteen patients with suspected acute appendicitis were included in the study.Of the 113 patients(62 males,51 females),the mean age was 30.2±10.1(range 18-67)years.Of the 113patients,94 patients underwent surgery,while the rest were followed non-operatively.Of the 94 patients,77patients were histopathologically diagnosed with acute appendicitis.Our study showed a sensitivity level of81%for the Alvarado system when a cut-off value of 6.5was used,a sensitivity level of 83.1%for the Ohmann system when a cut-off value of 13.75 was used,a sensitivity level of 80.5%for the Eskelinen system when a cut-off value of 63.72 was used,and a sensitivity level of 83.1%for the RIPASA system when a cut-off value of 10.25 was used.CONCLUSION:The Ohmann and RIPASA scoring systems had the highest specificity for the diagnosis of acute appendicitis. | Hasan Erdem Süleyman etinkünar Koray Das Enver Reyhan Cumhur Deger Mehmet Aziret Hilmi Bozkurt Seluk Uzun Selim Szen Oktay rkrücü | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 7 | Safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome显示文摘AIM:To evaluate the safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome.METHODS:This prospective randomized study comprised 100 eyes of 100 consecutive patients who underwent cataract surgery and implantation of foldable intraocular lens(IOL). Each eye was assigned to group 1 or group 2. Hydroimplantation without using viscoelastic agent as group 1(n=50), and hydroxypropylmethylcellulose(Eyevisc, Biotech, India) was used in group 2(n=50). RESULTS:There were no statistically significant differences in central corneal thickness(CCT) and corneal endothelial cell count(ECC) between both groups at each visit and percentage change in CCT and ECC(P>0.05). The mean intraocular pressure(IOP) at postoperative 5h increased statistically significantly in group 2(P<0.001). There was no statistically significant difference in IOP between two groups, before and after surgery excluding the 24 h postoperative IOP, but patients in group 2 had higher IOP than that in the group 1 at 24 h after surgery(P=0.035). No case in either group experienced posterior capsular rupture, or zonular dialysis. Fixation of the globe during IOL implantation was better in group 1 than that in group 2.CONCLUSION:Hydroimplantation has advantages in terms of IOP changes and duration of the surgery and seems to be safe in patients with pseudoexfoliation syndrome. | Tevfik Ogurel Reyhan Ogurel Zafer Onaran Kemal Ornek | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 2 |
| 8 | A MACHINE LEARNING APPROACH FOR MECHANISM SELECTION IN COMPLEX NEGOTIATIONS显示文摘 | Reyhan Aydogan Ivan Marsa-Maestre Mark Klein Catholijn M. Jonker | 2018 | Journal of Systems Science and Systems Engineering2018，27，2： | 2 |
| 9 | Risk factors for death and injuries in earthquake : cross-sectional study from Afyon, Turkey 显示文摘 | Hulya E Reyhan U Yusuf A | 2005 | Croatian medical Journal2005，46，4： | 1 |
| 10 | Risk factors for death and injuries in earthquake: cross-sectional study from Afyon,Turkey 显示文摘 | Hulya E Reyhan U Yusuf A | 2005 | Croatian medical Journal2005，46，4： | 1 |
| 11 | The effects of modified atmosphere gas composition on microbiological criteria, color and oxidation values of minced beef meat 显示文摘 | Ozlem Kizilirmak Esmer Reyhan Irkin | 2011 | Meat Science2011，，88： | 1 |
| 12 | Prognostic value of 18F-flu- orodeoxyglueose uptake in pelvic lymph nodes in patients with cer- vical cancer treated with definitive ehemoradiotherapy显示文摘 | Onal C Guler OC Reyhan M | 2015 | Gynecol Oneol2015，137，1： | 1 |
| 13 | Pelvic tuberculosis mimicking ovarian carcinoma显示文摘 | Tapisiz OL Reyhan H Cavkaytar S | 2005 | Int J Gynaecol Obstet2005，90，1： | 1 |
| 14 | Acute intraperitoneal rupture of hydatid cysts显示文摘 | Derici H Tansug T Reyhan E | 2006 | World J Surg2006，30，10： | 1 |
| 15 | Risk factors for death and inju- ries in earthquake: cross-sectianal study from Afyon, Turkey 显示文摘 | Hulya E Reyhan U Yusuf A | 2005 | Croatian Medical Journal2005，46，4： | 1 |
| 16 | Accuracy of surgeon- performed gallbladder ultrasound in identification of acute cholecystitis显示文摘 | Irkorucu O Reyhan E Erdem H | 2013 | J Invest Surg2013，26，2： | 1 |
| 17 | Risk factors for death and injuries in earthquake: cross sectional study from Afyon, Turkdy 显示文摘 | Hulya E Reyhan U Yusuf A | 2005 | CMJ2005，46，4： | 1 |
| 18 | Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population显示文摘AIM:To investigate the prevalence of coeliac disease in a series of Turkish patients with autoimmune thyroiditis.METHODS:Sera from 136 consecutive patients with newly diagnosed autoimmune thyroiditis and 119 healthy blood donors were tested for IgA tissue transglutaminase antibody with enzyme-linked immunosorbent assay.Endoscopic mucosal biopsy from the second part of duodenum was performed in patients with positive antibody test.RESULTS:Eight patients(5.9%)and one control subject(0.8%)were positive for IgA tissue transglutaminase antibody(OR:7.38,95% CI:0.91-59.85,P = 0.04).Six patients and one control agreed to take biopsies.Histopathological examination revealed changes classified as Marsh Ⅲa in one,Marsh Ⅱ in one,Marsh Ⅰ in two,and Marsh 0 in two patients with autoimmune throiditis,and MarshⅠin one blood donor.CONCLUSION:Turkish patients with autoimmune thyroiditis have an increased risk of coeliac disease and serological screening may be useful for early detection of coeliac disease in these patients.Our findings need to be confirmed in a larger series of patients. | Sefa Guliter Fahri Yakaryilmaz Zubeyde Ozkurt Reyhan Ersoy Derya Ucardag Osman Caglayan Pinar Atasoy | 2007 | World Journal of Gastroenterology2007，13，10： | 1 |
| 19 | The use of Bacillus subtilis iLmmobilized on Amberlite XAD-4 as a new biosorbent in trace metal determination显示文摘 | Mehmet Dogru Reyhan Gul-guven Salt Erdogan | 2007 | Journal of Hazardous Materials2007，149，1： | 1 |
| 20 | Treatment outcomes of pa- tients with cervical cancer with complete metabolic responses after definitive chemoradiotherapy 显示文摘 | Onal C Reyhan M Guler OC | 2014 | Eur J Nucl Med Mol Imaging2014，41，7： | 1 |
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