|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Benefits of the use of blood conservation in scoliosis surgery显示文摘AIM To investigate whether autologous blood transfusion(ABT) drains and intra-operative cell salvage reduced donor blood transfusion requirements during scoliosis surgery.METHODS Retrospective data collection on transfusion requirements of patients undergoing scoliosis surgery is between January 2006 and March 2010. There were three distinct phases of transfusion practice over this time: Group A received 'traditional treatment' with allogeneic red cell transfusion(ARCT) in response to an intra- or postoperative anaemia(Hb < 8 g/d L or a symptomatic anaemia); Group B received intra-operative cell salvage in addition to 'traditional treatment'. In group C,ABT wound drains were used together with both intra-operative cell salvage and 'traditional treatment'.RESULTS Data from 97 procedures on 77 patients,there was no difference in mean preoperative haemoglobin levels between the groups(A: 13.1 g/d L; B: 13.49 g/d L; C: 13.66 g/d L). Allogeneic red cell transfusion was required for 22 of the 37 procedures(59%) in group A,17 of 30(57%) in group B and 16 of 30(53%) in group C. There was an overall 6% reduction in the proportion of patients requiring an ARCT between groups A and C but this was not statistically significant(χ2 = 0.398). Patientsin group C received fewer units(mean 2.19) than group B(mean 2.94)(P = 0.984) and significantly fewer than those in group A(mean 3.82)(P = 0.0322). Mean length of inpatient stay was lower in group C(8.65 d) than in groups B(12.83) or A(12.62).CONCLUSION When used alongside measures to minimise blood loss during surgery,ABT drains and intra-operative cell salvage leads to a reduced need for donor blood transfusion in patients undergoing scoliosis surgery. | Peter R Loughenbury Lyeanda Berry Ben T Brooke Abhay S Rao Robert A Dunsmuir Peter A Millner | 2016 | World Journal of Orthopedics2016，7，12： | 3 |
| 4 | Pseudohypo parathyroidism with hypercalcemia 显示文摘 | Renuka RB Roger T Robert R | 2001 | Endocr2001，10，： | 1 |
| 5 | A comparison of the low moisture content limit to the logarithmic relation between seed moisture content and longevity in twelve species显示文摘 | Ellis R H Hong T D Roberts E H | 1989 | Annals of Botany1989，，63： | 1 |
| 6 | Employee research is a powerful tool in leading the time-based organization显示文摘 | Roberts D R and Rollins T | 1995 | Employee Relations Today1995，22，4： | 1 |
| 7 | Genetic variation of Japanese encephalitis virus in Nature 显示文摘 | WOAN R C ROBERT B T REBACA R R H | 1990 | J Gen Virol1990，71，2： | 1 |
| 8 | Mul- tialternative decision field theory: a dynamic connec- tionist model of decision making显示文摘 | ROBERT M R JEROME R B JAMES T T | 2001 | Psychological Review2001，108，2： | 1 |
| 9 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 10 | Diverticulitis in California from 1995 to 2006: Increased Rates of Treatment for Younger Patients显示文摘 | Etzioni David A Cannom Rebecca R Ault Glenn T Beart Robert W Kaiser Andreas M | 2009 | The American Surgeon2009，，10： | 1 |
| 11 | Exploring Variation in Active Network Size: Constraints and Ego Characteristics 显示文摘 | Roberts S G B Dunbar R I M Pollet T V | 2009 | Social Networks2009，31，2： | 1 |
| 12 | Identity, deep structure and the development of leadership skill 显示文摘 | Robert G Lord T Hall R J | 2005 | The Leadership Quarterly2005，16，： | 1 |
| 13 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 14 | A low-moisture-content limit to logarithmic relation between seed moisture content and longevity显示文摘 | Ellis R H Hong T D Roberts E H | 1989 | Annals of Botany1989，61，： | 1 |
| 15 | Active barrier to reduce phosphorus re- lease from sediments:Effectiveness of three forms of CaCO3 显示文摘 | Barry T H Simon R Robert J | 2003 | Aus- tralian Journal of Chemistry2003，56，3： | 1 |
| 16 | Syn- thesis of Isoambrettolide and Its Isomers from 1,9-cy- clohexadecadiene显示文摘 | BRAJA D M ROBERT W T RAMAN R P | 1972 | J Org Chem1972，37，24： | 1 |
| 17 | Techniques for the study and development of microbial fuel cells: an electrochemical perspective 显示文摘 | Zhao F Robert C T S John R V | 2009 | Chem Soc Rev2009，38，： | 1 |
| 18 | Non-extractable pesticide residues in soils and plants显示文摘 | ROBERT T R | 1984 | Pure and Applied Chemistry1984，56，： | 1 |
| 19 | Low moisture content limit to relation between seed longevity and moisture显示文摘 | Ellis R H Hong T D Roberts E H | 1990 | Annals of Botany1990，，65： | 1 |
| 20 | In-terferons and the maternal-conceptus dialog in mam-mals显示文摘 | ROBERTS R M CHEN Y EZASHI T et a1 | 2008 | Semin Cell Dev Biol2008，19，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员