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| 1 | 氯吡格雷的使用与药物洗脱支架植入后远期临床结果显示文摘背景:近来的冠状动脉内药物洗脱支架研究提示,现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的:于接受药物洗脱支架(drug-eluting stents,DESs)和裸金属支架(bare-metal stents,BMSs)治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者:于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心(一家位于北卡罗来纳州达累姆市的三级治疗中心)接受冠状动脉内支架治疗。于6、12、24个月时进行随访,直至2006年9月7日。研究人群包括4666例最初接受BMS(n=3165)或DES(n=1501)经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件(没有死亡、心肌梗死或血管重建手术)的患者进行界标分析(landmark analysis)。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组:DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标:随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果:在6个月时没有事件发生的DES组患者(637例使用、579例未使用氯吡格雷)中,氯吡格雷的使用是随访24个月校正死亡率较低(使用2.0%比未使用5.3%;差异,-3.3%;95%CI,-6.3%至-0.3%;P=0.03)以及死亡或心肌梗死发生率较低(3.1%比7.2%;差异,-4.1%;95%CI,-7.6%至-0.6%;P=0.02)的显著预测指标。然而,在BMS组患者中(417例使用、1976例未用氯吡格雷),死亡(3.7%比4.5%;差异,-0.7%;95%CI,-2.9%至1.4%;P=0.50)以及死亡或心肌梗死发生率(5.5%比6.0%;差异,-0.5%;95%CI,-3.2%至2.2%;P:0.70)没有差异。在12个月随访没有事件发生的DES组患者(252例使用、276例未用氯吡格雷)中,氯吡格雷的使用依然可以预测24个月死亡(0%比3.5%;差异,-3.5%;95%CI,-5.9%至-1.1%;P=0.004)以及死亡或心肌梗死发生率(0%比4.5%;差异,-4.5%;95%CI,-7.1%至-1.9%;P〈0.001)较低。然而,在BMS组患者中(346例使用、1644例未用氯吡格雷),在死亡(3.3%比2.7%;差异,0.6%;95%CI,1.5%至2.8%;P=0.57)以及死亡或心肌梗死(4.7%比3.6%;差异,1.0%;95%CI,-1.6%至3.6%;P=0.44)发生方面,依然没有差异。结论:在接受DES治疗的患者中,延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而,使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。 | Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD Linda K. Shaw, MS Robert H. Tuttle, MSPH Daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿(译) David E. Kandzari, MD | 2007 | 美国医学会杂志(中文版)2007，26，3： | 60 |
| 2 | 对骨折内固定术后早期感染者保留内固定物的策略显示文摘背景:开放复位内固定术后,在内固定物存在的情况下治疗伤口深部感染极为棘手,关于治疗方案的使用,文献报道甚少。本研究旨在探讨骨折内固定术后6周内发生感染后保留内固定物直至骨性愈合的可能性。方法:通过回顾3个I级创伤中心以往的病历和创伤登记表,共纳入121例新鲜骨折患者,这些患者术中细菌培养均为阳性,内固定术后6周内共123处创口发生感染。统计保留内固定物并获骨折愈合者的比率,评价预测其治疗成败的指标。结果:86例患者(87处骨折;71%)经手术清创、保留内固定物和敏感抗生素治疗获得骨折愈合。治疗失败的有关因素包括开放性骨折(p=0.03)和髓内钉固定(p=0.01)。其他非明显相关但有相关倾向的变量包括吸烟、假单胞菌感染以及累及股骨、胫骨、踝部或足部的骨折。结论:骨折内固定术后深部感染者可通过手术清创、敏感抗生素治疗及保留内固定物成功获得骨折愈合。这些结果可通过基于危险基因、特定菌种和有关的内固定种类对患者进行选择而获得改善。 | Marschall Berkes, MD William T. Obremskey, MD MPH, Brian Scannell, MD J. Kent Ellington, MD Robert A. Hymes, MD Michael Bosse, MD, and the Southeast Fracture Consortium 黄哲元(译) 丁真奇(译) | 2010 | 中华骨科杂志2010，30，9： | 21 |
| 3 | 骨科教程 膝关节内侧副韧带及内侧结构的损伤显示文摘内侧副韧带浅层及其他内侧的膝关节稳定结构——如,内侧副韧带深层和后斜韧带——是损伤最为多见的膝关节韧带性结构。 | Coen A. Wijdicks, PhD Chad J. Griffith, MD Steinar Johansen, MD Lars Engebretsen, MD, PhD Robert F. LaPrade, MD, PhD 夏志敏(译) | 2010 | 中华骨科杂志2010，30，9： | 8 |
| 4 | Morbidity and Mortality Analysis of 200 Treatments With Cytoreductive Surgery and Hyperthermic Intraoperative Intraperitoneal Chemotherapy Using the Coliseum Technique显示文摘 | Arvil D. Stephens MD Robert Alderman PA-C David Chang MD Gary D. Edwards PA-C Jesus Esquivel MD Gilbert Sebbag MD Mark A. Steves MD Paul H. Sugarbaker MD | 1999 | Annals of Surgical Oncology1999，，8： | 5 |
| 5 | Borderline Resectable Pancreatic Cancer: Definitions, Management, and Role of Preoperative Therapy显示文摘 | Gauri R. Varadhachary MD Eric P. Tamm MD James L. Abbruzzese MD Henry Q. Xiong MD Christopher H. Crane MD Huamin Wang MD Jeffrey E. Lee MD Peter W. T. Pisters MD Douglas B. Evans MD Robert A. Wolff MD | 2006 | Annals of Surgical Oncology2006，，8： | 4 |
| 6 | Intraductal Papillary Mucinous Neoplasms of the Pancreas: Effect of Invasion and Pancreatic Margin Status on Recurrence and Survival显示文摘 | Chandrajit P. Raut MD Karen R. Cleary MD Gregg A. Staerkel MD James L. Abbruzzese MD Robert A. Wolff MD Jeffrey H. Lee MD Jean-Nicolas Vauthey MD Jeffrey E. Lee MD Peter W. T. Pisters MD Douglas B. Evans MD | 2006 | Annals of Surgical Oncology2006，，4： | 3 |
| 7 | Acute pancreatitis and organ failure: Pathophysiology, natural history, and management strategies显示文摘 | Michael G. T. Raraty FRCS PhD Saxon Connor FRACS David N. Criddle PhD Robert Sutton DPhil FRCS John P. Neoptolemos MA MD FRCS | 2004 | Current Gastroenterology Reports2004，，2： | 2 |
| 8 | Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘 | Niraj J. Gusani MD Sung W. Cho MD Christos Colovos MD PhD Songwon Seo MS Jan Franko MD PhD Scott D. Richard MD Robert P. Edwards MD Charles K. Brown MD PhD Matthew P. Holtzman MD Herbert J. Zeh MD David L. Bartlett MD | 2008 | Annals of Surgical Oncology2008，，3： | 2 |
| 9 | Endoscopic third ventriculostomy in children:problems and surgical outcome:analysis of 34 cases显示文摘Background:Endoscopic third ventriculostomy(ETV)has been established as a viable treatment option for obstructive hydrocephalus of children over 6 weeks of age.ETV in pediatric groups may be unsuccessful due to the failure of absorption of cerebrospinal fluid(CSF)or reclosure of ventriculostomy stoma or due to infection.The exact cause is still debatable.Some issues like failure to eliminate the second membrane during the procedure or formation of the new arachnoid membrane at the stoma are still not clear.This study aims to assess the surgical failure of ETV and its predisposing factors.Methods:Thirty-four pediatric patients with hydrocephalus were analyzed retrospectively.The patients’age limit was between 2.5 months and 14 years.This is a retrospective study of 34 patients in a single private hospital between June 2012 and January 2018.Patients having hydrocephalus in pediatric groups more than 6 weeks of age were included in the study.Results:The mean age of all patients was 51.25±53.90 months and the mean follow-up period was 50.47±20.84 months.Of 34 surgeries,the success rate was 79%and the failure rate was 21%.Within 2 years,the success rate was 68.42%and above 2 years’success rate was 93.33%.In this series,7 cases of ETV were re-explored and found ventriculostomy stoma closure in 3 cases,the presence of the second membrane in re-exploration 2 cases,and presence of inflammatory arachnoid membrane in re-exploration 2 cases.The use of dexamethasone around the stoma in inflammatory stoma was useful,having no recurrence.In one patient of the second membrane probably due to absorption failure in communicating hydrocephalus re-exploration was failed and was managed successfully with VP shunt.Conclusions:Predisposing factors causing ETV failure are ventriculostomy stoma closure by new arachnoid granulation tissues,remnants of the second membrane inside the stoma,CSF absorption failure,infection/high protein in CSF and inappropriate patient selection. | Md Moshiur Rahman S.I.M.Khairun Nabi Khan Robert Ahmed Khan Rokibul Islam Mainul Haque Sarker | 2021 | Chinese Neurosurgical Journal2021，7，2： | 2 |
| 10 | Accuracy of Determining Nodal Negativity in Colorectal Cancer on the Basis of the Number of Nodes Retrieved on Resection显示文摘 | Natalie E. Joseph MD Elin R. Sigurdson MD PhD Alexandra L. Hanlon PhD Hao Wang MS Robert J. Mayer MD John S. MacDonald MD Paul J. Catalano ScD Daniel G. Haller MD | 2003 | Annals of Surgical Oncology2003，，3： | 2 |
| 11 | Chemistry for peptide and protein PEGylation 显示文摘 | ROBERT MJ BENTLEY MD HARRIS JM | 2002 | Adv Drug Deliver Rev2002，54，4： | 1 |
| 12 | Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice 显示文摘 | Clement AM Nguyen MD Roberts EA | 2003 | Science2003，302，5645： | 1 |
| 13 | Analysis of regional cerebral blood flow in dogs with experimental microbubble based US contrast agent 显示文摘 | Robert S Grenberg MD George A | 1996 | Radiology1996，201，： | 1 |
| 14 | Changing spectrum of choleloth- iasis and cholecystitis in infants and children显示文摘 | Patrik V Bailey MD Robert H | 1989 | Am J Sury1989，158，20： | 1 |
| 15 | A Retrospective Review of Enteroclysis in Patients with Obscure Gastrointestinal Bleeding and Chronic Abdominal Pain of Undetermined Etiology显示文摘 | Aslam Malik MD Kathleen Lukaszewski MD Dina Caroline MD Henry Parkman MD Joshua DeSipio MD Felice Banson MD Khalid Bazir MD Lakshmi Reddy MD Radhika Srinivasan MD Robert Fisher MD Larry Miller MD | 2005 | Digestive Diseases and Sciences2005，，4： | 1 |
| 16 | Development and validation of a pregnancy physical activity questionnaire显示文摘 | Chasan-Taber L Schmidt MD Roberts DE | 2004 | Med Sci Sports Exerc2004，36，10： | 1 |
| 17 | Tigger thumb: Pediatric Orthopaedics 显示文摘 | Wood W Lovell MD Robert B | 1986 | Second Edition1986，2，： | 1 |
| 18 | Infection as a cause of preterm birth显示文摘 | Goldenberg MD Jennifer Flatw Culhane | 2003 | Clin Perinatol2003，30，： | 1 |
| 19 | Recalcitrant nonunion of the distal humerus:Treatment with free wascularized bonegrafting显示文摘 | Beredjiklian Pedro K MD Hotchkiss Robert N MD Athanasian Edward A MD | 2005 | Clin Orthop2005，435，： | 1 |
| 20 | Pathophysiology of restenosis: interaction of thrombsis hyperplasia and remodeling显示文摘 | Robert S Schwarz MD | 1998 | Am J Cardial1998，81，7： | 1 |
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