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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Submemed macrophytes and the hydraulic reushhess of a lowland chalkstream显示文摘 | DAWSON F H ROBINSON W N | 1984 | Verhandlung Internationale Vereinigung Limnologie1984，，22： | 1 |
| 3 | Real-world automotive emissions-summary of studies in the Fort McHenry and Tuscarora Mountain Tunnels显示文摘 | Pierson W R Gertler A W Robinson N F | 1996 | Atmospheric Environment1996，30，12： | 1 |
| 4 | Real world automotive emissions-a summary of studies in the Fort McHemy andTuscarora Mountain Tunnels 显示文摘 | PIERSON W R GERTLER A W ROBINSON N F | 1996 | Atmospheric Environment1996，30，12： | 1 |
| 5 | Ectopic ossification following total hip replacement: incidence and a method of classification 显示文摘 | Brooker A F Bowerman J W Robinson R A | 1973 | J Bone Joint Surg Am1973，55，8： | 1 |
| 6 | Bioresorbable nanofibepbased systems for wound healing and drug de- livery: optimization of fabrication parameters 显示文摘 | Katti S R Robinson K W Ko F K | 2004 | Bi- omed Mater Res Part B: Appl Biomater2004，70，： | 1 |
| 7 | Real-world automotive emissions-summary of studies in the Fort McHenry and Tuscarora Mountain rannels显示文摘 | Piersun W R Gertler A W Robinson N F | 1996 | Atmospheric Environment1996，30，： | 1 |
| 8 | Real-world automotive emissions summary of studies in the FortMcHenry and Tuscarora Mountain Tunnels显示文摘 | Pierson W R Gertler A W Robinson N F | 1996 | AtmosphericEnvironment1996，30，： | 1 |
| 9 | National cancer data base report on malignant paragangliomas of the head and neck显示文摘 | Lee J H Barich F Karnell L H Robinson R A Zhen W K Gantz B J | 2002 | Cancer2002，94，： | 1 |
| 10 | Magnetic lens technology in X-ray Photoelectron-Spectroscopy (XPS)-facts and fallacies显示文摘 | Robinson K S Street F J Drummond I W | 1993 | Inst Phys Conf Ser1993，130，6： | 1 |
| 11 | Transmission of viruses by plant nematodes显示文摘 | Brown D J F Robinson W M Trudgitl D L | 1995 | Annu Rev Phytopathol1995，，33： | 1 |
| 12 | The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions显示文摘 | Whitehurst A W Robinson F L Moore M S | 2004 | J Biol Chem2004，279，12： | 1 |
| 13 | Perforation of the great vessels during central venous line placement 显示文摘 | Robinson J F Robinson W A Cohn A | 1995 | Arch Inter Med1995，155，1： | 1 |
| 14 | Isomers of conjugated linoleic acid(CLA)are incorporated into egg yolk lipids by CLA-fed laying hens显示文摘 | Jones S Ma D W Robinson F E | 2000 | The Journal of Nutrition2000，130，8： | 1 |
| 15 | Formation of Podiform Chromitites by Melt/Rock Interaction in the Upper Mantle 显示文摘 | Zhou M F Robinson P T Bai W J | 1994 | Mineralium Deposita1994，29，： | 1 |
| 16 | Introducing mothur: open- source, platform-independent, community-supported software for describing and comparing microbial communities显示文摘 | Schloss P D Westcott S L Ryabin T Hall J R Hartmarm M Hollister E B Lesniewski RA Oakley B B Parks D H Robinson C J Sahl J W Stres B ThaUinger G G Van Horn D J Weber C F | 2009 | Applied and Environmental Microbiology2009，75，23： | 1 |
| 17 | Heterologous expression of an immunogenic pneumococcal type 3capsular polysaccharide in Lactococus lactis显示文摘 | Gilbert C Robinson K Le Page R W F | 2000 | Infectiou and Immunity2000，68，： | 1 |
| 18 | Light-induced expression of a MYB gene regulates anthocyanin biosynthesis in red apples显示文摘 | TAKOS A M JAFFI~ F W JACOB S R BOGS J ROBINSON S P WALKER A R | 2006 | Plant Physiology2006，142，3： | 1 |
| 19 | Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolaetin signal transduction in mouse mammary tissue显示文摘 | LIU X ROBINSON G W GOUILLEUX F | 1995 | Proc Natl Acad Sci USA1995，92，19： | 1 |
| 20 | Light-induced expression of a MYB gene regulates anthocyanin biosynthesis in red apples显示文摘 | TAKOS A M JAFFI~ F W JACOB S R BOGS J ROBINSON S P WALKER A R | 2006 | Plant Physiology2006，142，3： | 1 |
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