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| 1 | Novel and emerging diabetes mellitus drug therapies for the type 2 diabetes patient显示文摘Type 2 diabetes mellitus is a metabolic disorder of deranged fat, protein and carbohydrate metabolism resulting in hyperglycemia as a result of insulin resistance and inadequate insulin secretion. Although a wide variety of diabetes therapies is available, yet limited efficacy, adverse effects, cost, contraindications, renal dosage adjustments, inflexible dosing schedules and weight gain significantly limit their use. In addition, many patients in the United States fail to meet the therapeutic HbA1c goal of < 7% set by the American Diabetes Association. As such new and emerging diabetes therapies with different mechanisms of action hope to address some of these drawbacks to improve the patient with type 2 diabetes. This article reviews new and emerging classes, including the sodium-glucosecotransporter-2 inhibitors, 11β-Hydroxysteroid dehydrogenase type 1 inhibitors, glycogen phosphorylase inhibitors; protein tyrosine phosphatase 1B inhibitors, G Protein-Coupled receptor agonists and glucokinase activators. These emerging diabetes agents hold the promise of providing benefit of glucose lowering, weight reduction, low hypoglycemia risk, improve insulin sensitivity, pancreatic β cell preservation, and oral formulation availability. However, further studies are needed to evaluate their safety profile, cardiovascular effects, and efficacy durability in order to determine their role in type 2 diabetes management. | Charmaine D Rochester Oluwaranti Akiyode | 2014 | World Journal of Diabetes2014，5，3： | 3 |
| 2 | Extragonadal seminoma involving urinary bladder and arising in the prostate 显示文摘 | Khandekar J D Holland J M Rochester D | 1993 | Cancer1993，71，12： | 1 |
| 3 | The structure and expression of maize genes encoding the major heat shock protein, hsp70 显示文摘 | Rochester D E Winer J A Shah D M | 1986 | EMBO Journal1986，5，： | 1 |
| 4 | An irrigation scheduling model which incorporates rainfall predictions显示文摘 | Rochester E W Busch C D | 1972 | Journal of the American Wa- ter Resources Association1972，8，3： | 1 |
| 5 | Accuracy of placenta localization by uhrasound显示文摘 | Bowier JD Rochester D Cadkin AV | 1978 | Radiology1978，128，1： | 1 |
| 6 | Nonlinear magneto-optical rotation via alignment-to-orientation conversion显示文摘 | Budker D Kimball DF Rochester SM | 2000 | Phys Rev Lett2000，85，10： | 1 |
| 7 | Compressibility, core dynamics and the subseismic wave equation显示文摘 | Smylie D E Rochester M G | 1981 | Geophysics of the Earth and Planetary Interiors1981，24，： | 1 |
| 8 | Controlling emission energy, self-quenching, and excimer formation in highly luminescent WCAN-coordinated platinum ( II ) complexes 显示文摘 | Farley S 1 Rochester D L Thompson A L | 2005 | Inorg Chern2005，44，26： | 1 |
| 9 | The subseismic approximation in core dynamics 显示文摘 | Crossley D J Rochester M G | 1992 | Geophysical Journal International1992，108，： | 1 |
| 10 | Evaluation of a polyolefin coated urea(Meister)as a fertilizer for irrigated cotton显示文摘 | Chen D Freney J R Rochester I et ol | 2008 | Nutrient Cycling in Agroecosystems2008，81，3： | 1 |
| 11 | Nonlinear magneto-optics and reduced group velocity of light in atomic vapor with slow ground state relaxation显示文摘 | Budker D Kimball D F Rochester S M | 1999 | Phys Rev Lett1999，83，9： | 1 |
| 12 | A res nance raman spectroscopic study of the protonation of 2- (4'-hydroxazo)-benzoic acid adsorbed on oxide surfaces 显示文摘 | Dines T J MacGregor L D Rochester C H | 2003 | Vibrational Spectroscopy2003，32，2： | 1 |
| 13 | Nonlinear Magneto-optics and Reduced Group Velocity of Light in Atomic Vapor with Slow Ground State Relaxation 显示文摘 | BUDKER D KIMBALL D F ROCHESTER S M | 1999 | Phys Rev Lett1999，83，： | 1 |
| 14 | The effect of external rhythmic cues(auditory and visual)on walking during a functional task in homes of people with Parkinson's disease显示文摘 | Rochester L Hetherington V Jones D | 2005 | Arch Phys Med Rehabil2005，86，5： | 1 |
| 15 | The structure and expression of maize genes encoding the major heat shock protein, hsp70显示文摘 | Rochester D E Winer J A Shah D N | 1986 | EMBOJ1986，5，3： | 1 |
| 16 | Assessment of airway function during assisted ventilation显示文摘 | LAVIETES M H ROCHESTER D F | 1981 | Lung1981，159，4： | 1 |
| 17 | The effect of external rhythmic cues (auditory and visual) on walking during a functional task in homes of people with Parkinson's disease显示文摘 | Rochester L Hetherington V Jones D | 2005 | Arch Phys Med Rehabil2005，86，5： | 1 |
| 18 | Attending to the task:interference effects of functional tasks on walking in Parkinson's disease and the roles of cognition,depression,fatigue,and balance显示文摘 | Rochester L Hetherington V Jones D | 2004 | Arch Phys Med Rehabil2004，85，： | 1 |
| 19 | Histiocytic cytophagic panniculitis显示文摘 | Alegre V Winkelmann R Rochester D | 1989 | Am Acad Dermatol1989，20，： | 1 |
| 20 | Evaluation of a polyolefin coated urea (Meister)as a fertilizer for irrigated cotton显示文摘 | Chen D L Freney J R Rochester I Constable G A Moiser A R and Chalk P M | 2008 | Nutr Cycl Agroecosyst2008，81，： | 1 |
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